NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 24 for “"NMDA receptor antagonist"”.

  1. The medial prefrontal cortex and the dorsomedial striatum are necessary for working memory in rats: role of NMDA receptors

    Davies, Don 1985-University of Saskatchewan2016

    … the contrbutions of N-methyl-D-aspartate (NMDA) receptors in medial prefrontal cortex (mPFC) and dorsomedial striatum (dmSTR) using two working memory tasks. The trial unique non-match to location (TUNL) task is a delayed-non-match-to-sample visual working memory task performed in …

    sask Repository record

  2. Angiotensin II Modulation of NMDA Receptor Function: Characterization of Mechanisms Attenuating Excitotoxicity in Neurons

    Schelman, William RussellUniversity of Illinois at Urbana-Champaign2015

    … the involvement of Bcl-2 in the suppression of NMDA-mediated neurotoxicity by Ang II. The viability of differentiated N1E and NG108 neuronal cell lines was reduced following exposure to NMDA in a dose-dependent manner. Excitotoxicity in N1E cells was inhibited by the noncompetitive NMDA receptor …

    uiuc Repository record

  3. Effects of NMDA Receptor Antagonists on the Differential-Reinforcement-of-Low-Rate 72 Second (DRL 72) Responding in Rats

    Lynch, Cayla2025

    <p>The noncompetitive NMDA receptor antagonist dextromethorphan and its metabolite dextrorphan have widespread effects on the central nervous system. Dextromethorphan alone and with quinidine (a CYP-450 2D6 inhibitor) have been shown to produce antidepressant effects in preclinical and clinical …

    nmu Repository record

  4. An assessment of reconsolidation blockade to disrupt memories relevant to psychiatric disorders

    Vousden, George HenryUniversity of Cambridge2017

    … of the resultant process, reconsolidation, with NMDA receptor antagonists or protein synthesis inhibition can lead to a decrease in subsequent memory expression. This may offer a potential tool for the treatment of psychiatric disorders characterised by maladaptive memories, including drug …

    cambridge Repository record

  5. EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY

    Roesner, Shelby F2030

    … (mTOR). Preclinical studies suggest that sigma-1 receptor agonists produce antidepressant-like drug effects and affect the mTOR pathway. Other mechanisms include serotonin neurotransmission and N-methyl-D-aspartate (NMDA) receptors. This study evaluated drugs acting as sigma-1 agonists, NMDA …

    nmu Repository record

  6. Optimizing Treatment for Depression: Integrating TMS and Ketamine Through Provider and Clinical Staff Education

    Grancorvitz, Gillian RosemaryThe University of Arizona.2025

    … Novice treatments for TRD include ketamine, an NMDA receptor antagonist, and TMS, a non-invasive brain stimulation technique, both of which have demonstrated effectiveness. However, many of those who are involved in the care of those receiving ketamine, TMS, or both remain unaware of the …

    arizona-thes Repository record

  7. Excretory nitrogen metabolism in the Chinese soft-shelled turtle, pelodiscus sinensis

    LEE MIN LIN, SERENE2007

    … dose of NH4Cl. Through the use of MK801 (an NMDA receptor antagonist) and MSO (a glutamine synthetase inhibitor) prior to a lethal dose of NH4Cl, it appears that ammonia toxicity in P. sinensis involves the activation of NMDA receptors and that glutamine accumulation could not be the major …

    nus Repository record

  8. A behavioural evaluation of the potential of nNOS inhibitors to control dyskinesia in animal models of Parkinson’s disease

    Hirsch, TamaraKing's College London2012

    … with amantadine, an N-methyl-D-aspartate (NMDA) receptor antagonist. NMDA receptor activation is linked with nitric oxide (NO) production and changes in synaptic plasticity, suggesting a role in dyskinesia. This led to the hypothesis that NO, produced by neuronal nitric oxide synthase …

    kings Repository record

  9. The Effect of Typical and Atypical Antipsychotics on the MK-801 Induced Deficit in Behavioural Inhibition

    Tuplin, ErinCarleton University2014

    The non-competitive NMDA receptor antagonist (+)-5-methyl-10, 11-dihydro- 5H-dibenzo [a, d,] cyclohepten-5-10-imine maleate (MK-801) has been shown to produce deficits in behavioral inhibition measured as the lack of extinction during operant procedures. As such, MK-801 has the potential to be used …

    carleton Repository record

  10. The Protective Effects of Memantine On The Morphology and Activity of Irradiated Dendritic Spines

    Lam, Thanh, <p>https://orcid.org/0000-0003-1381-1892</p>2018

    … mice and pre-treatment of memantine, an NMDA receptor antagonist, prevented this decrease. Data also suggested that irradiation could have acute effects on the density and morphology of prefrontal cortical dendritic spines. Irradiation induced a decrease in spine density, decrease in …

    uthsc Repository record

  11. A toxicological analysis of the cyanotoxin β-methylamino-L-alanine at multiple neural levels and identification of novel modes of activity

    Chiu, Alexander Simon Che-KeanUNSW, Sydney2013

    … in the presence of the N methyl-D-aspartate (NMDA) receptor antagonist MK801 indicates that the neurotoxic effects of BMAA are mediated via NMDA receptor activation. Immunocytochemical stains show that BMAA induces the expression of neuronal nitric oxide synthase (nNOS) and caspase-3 …

    unsw Repository record

  12. The Effects of Repeated Ketamine Administration During Adolescence on Anxiety and Depressive-like Behaviors Induced by a Predator Odor

    Haas, Shannon L.2014

    … its rapid effects. Ketamine is a noncompetitive NMDA receptor antagonist that stimulates glutamate transmission. The efficacy of non-competitive NMDA receptor antagonists in anxiety treatment, however, lacks consistent findings. The goal of the present study was to examine the effects of repeated …

    shu-thes Repository record

  13. On The Future Of Antidepressant Treatments: Targeting Neurotrophic Factors And Plasticity

    White, Stephen W2019

    … or alterations in their post-synaptic receptors are responsible for depressive symptoms. Drugs designed to elevate synaptic monoamine levels have remained the first line of pharmacotherapy prescribed by clinicians for MDD patients. However, these drugs have shortcomings. Despite …

    mississippi Repository record

  14. KETAMINE EXPOSURE DURING ADOLESCENCE INCREASES SENSITIVITY TO REWARD-RELATED STIMULI IN ADULTHOOD

    Riggs, Lace Marie2016

    … the non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist, ketamine, has been shown to alleviate symptoms of MDD in individuals that suffer from treatment-resistant depression. However, little is known about the potential long-term consequences of ketamine exposure during early …

    csusb Repository record

  15. Large-scale neural recordings and biophysical models for inferring network mechanisms of ketamine anesthesia

    Kowalski, Marek Mateusz2021

    Ketamine is an NMDA receptor antagonist with powerful anesthetic, antidepressant, and psychotomimetic effects. At all therapeutic doses, ketamine generates robust gamma oscillations between 30-80 Hz that are typical of active, structured cognition; yet, under ketamine, gamma oscillations persist …

    bu Repository record

  16. Differential Expression of Cell Adhesion Molecules by Neuronal Injury

    장, 유나2011

    … mRNA expression was significantly reduced by NMDA in pure cortical neurons and mixed cortical neurons with glial cells. Especially, in pure cortical neurons, NMDA reduced N-cadherin in dose dependent manner, and NMDA receptor antagonist MK-801 is restored NMDA-induced reducing of N-cadherin …

    ajou Repository record

  17. Full-Gestational Exposure to Nicotine and Ethanol Results in Long-Term Dysregulation in the Ventral Tegmental Area

    Roguski, Emily Elizabeth2016

    … also show sensitivity to n-methyl-d-aspartate (NMDA) in the VTA of offspring that results in a greater increase in NAcc DA and VTA glutamate release compared to the PF offspring. The enhanced acquisition of nicotine SA seen in Nic+EtOH offspring can be reduced to PF levels with disruption to the …

    tenn-hsc Repository record

  18. A study of the WKY as a rat model of depression

    Van Zyl, Petrus JurgensDepartment of Human Biology2015

    … The glutamate N - methyl - D - aspartate (NMDA) receptor antagonist, ketamine, has been found to be clinically useful. The acute effects of ketamine have not been previously tested in male WKY or MS SD rats and it was therefore decided to study the behavioural effects of ketamine in these …

    cape-town Repository record

  19. Newly Synthesized Pyroglutamate Amide and its Neuroprotective Effect Against Neurotoxicity Induced Cell Death in Alzheimer's Disease

    Elamrani, Nourelhouda JouteyThe Graduate School and University Center of The City University of New York2024

    … exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity leading to the cell death. One of the most common neurodegenerative disorders is Alzheimer’s disease (AD), which represents 60 – 70% of cases and it ranked fourth cause of mortality in the USA. In …

    cuny-grad Repository record

  20. Exploration of cognitive and neurochemical deficits in an animal model of schizophrenia. Investigation into sub-chronic PCP-induced cognitive deficits using behavioural, neurochemical and electrophysiological techniques; and use of receptor-selective agents to study the pharmacology of antipsychotics in female rats.

    McLean, SamanthaUniversity of Bradford2010

    … with drug treatment. The non-competitive NMDA receptor antagonist, phencyclidine (PCP), is a psychomotor stimulant drug that has been shown to induce symptoms characteristic of schizophrenia in humans and animals. The aim of these studies was to use the sub-chronic PCP model in rats to …

    bradford Repository record

Page 1 of 2