Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 141 for “"NMDA receptor"”.
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Agonist-Induced Conformational Changes In The Nmda Receptor
<p>NMDA receptors are ligand-gated ion channels that mediate a number of physiological and pathological phenomena within the mammalian central nervous system. Under the typical course of activation, these receptors bind to glycine and glutamate molecules and undergo a series of conformational …
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RABPHILIN3A: FROM NMDA RECEPTOR MEMBRANE DYNAMICS TO NEURODEVELOPMENTAL DISORDERS
… spines. It promotes the stabilization of the NMDA-type glutamate receptors (NMDARs) at the cell surface, forming a ternary complex with the PSD-95 and GluN2A subunit of the receptor. This complex is needed for long-term potentiation (LTP) induction and NMDAR-dependent hippocampal behaviors, …
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Functional role of NMDA receptor subunit composition in metaplasticity
… in the subunit composition and function of NMDA-type glutamate receptors (NMDARs). However, causality has not been conclusively established. Here we examined the mechanistic basis of metaplaticity, and specifically how this process is mediated by a switch in NMDAR subunit composition by …
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Probing spatial and subunit-dependent signalling by the NMDA receptor
NMDARs are ligand-gated cation channels which are activated by the neurotransmitter glutamate. NMDARs are essential in coupling electrical activity to biochemical signalling as a consequence of their high Ca2+ permeability. This Ca2+ influx acts as a secondary messenger to mediate neurodevelopment, …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… are mediated via N-methyl D-aspartate receptor (NMDAR)-dependent signaling mechanisms. Inasmuch as neuronal activity involves activation of voltage-gated sodium channels (VGSCs) primarily, in this study, we used a sodium channel activator, brevetoxin-2 (PbTx-2) to mimic neuronal …
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Fret-Based Investigations of The Structure-Function Relationships In The Nmda Receptor
<p>The <em>N</em>-methyl-D-aspartate (NMDA) receptor is one member of a class of proteins known as the ionotropic glutamate receptors. Ionotropic glutamate receptors mediate the majority of excitatory neurotransmission in the central nervous system, with the NMDA receptor standing out among these …
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Effect of age and unilateral dopamine depletion on striatal NMDA receptor function
Includes bibliographical references.
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The Structural Mechanism of Allosteric Modulation of The Nmda Receptor: A Balance of Tensions
<p>N-methyl-D-aspartate (NMDA) receptors are one of the three main types of ionotropic glutamate receptors in the central nervous system. NMDA receptors mediate the rapid excitatory neurotransmission that underlies learning and memory formation. Conversely, NMDA receptors are implicated in a …
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State-dependent changes in astrocyte regulation of extrasynaptic NMDA receptor signaling in neurosecretory neurons
… the long-established presence of glutamate NMDA receptors at extrasynaptic sites (eNMDARs), their functional roles remain poorly understood. Factors influencing the concentration and time course of glutamate in the extrasynaptic space, such as the topography of the neuronal–glial …
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Angiotensin II Modulation of NMDA Receptor Function: Characterization of Mechanisms Attenuating Excitotoxicity in Neurons
… the involvement of Bcl-2 in the suppression of NMDA-mediated neurotoxicity by Ang II. The viability of differentiated N1E and NG108 neuronal cell lines was reduced following exposure to NMDA in a dose-dependent manner. Excitotoxicity in N1E cells was inhibited by the noncompetitive NMDA receptor …
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Domains of the NR2A and NR2B subunits involved in NMDA receptor current modulation by PKC.
Domains of the NR2A and NR2B subunits involved in NMDA receptor current modulation by PKC.
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Involvement of the NMDA Receptor in Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta in Vitro
… possible "sensor" roles of certain cell surface receptors in MEP-mediated neuroprotection from Aβ in vitro. Specifically, Gαi protein-coupled receptors and/or glutamatergic N-methyl-D-aspartate receptors (NMDAR) have been shown to be involved in other neuroprotective preconditioning mechanisms. …
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… over-activation of post-synaptic glutamatergic receptors has long been established as a key contributor to neuronal death. Also contributing to ischemic/reperfusion-induced neuronal death is oxidative stress, chemically defined as a pathologic state within the cell arising from the increased …
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… over-activation of post-synaptic glutamatergic receptors has long been established as a key contributor to neuronal death. Also contributing to ischemic/reperfusion-induced neuronal death is oxidative stress, chemically defined as a pathologic state within the cell arising from the increased …
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Effects of NMDA Receptor Antagonists on the Differential-Reinforcement-of-Low-Rate 72 Second (DRL 72) Responding in Rats
<p>The noncompetitive NMDA receptor antagonist dextromethorphan and its metabolite dextrorphan have widespread effects on the central nervous system. Dextromethorphan alone and with quinidine (a CYP-450 2D6 inhibitor) have been shown to produce antidepressant effects in preclinical and clinical …
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Evaluation of the Role of Astrocyte Glutamate Transport and of Synaptic NMDA Receptor Subtype Representation in the Pathogenesis of PTSD
… GLT-1, and regional differences in expression of NMDA receptor subtypes in the development of a rat model of PTSD. We hypothesized that impaired astrocytic glutamate reuptake inhibits long-term memory processes, and that concurrent presence of glucocorticoids (GCs) during situational trauma …
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