Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"NMDA antagonist"”.
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Roles of dopamine D1 and D2, opioid and glutamate NMDA receptor signaling in the acquisition and expression of fat- and glucose-conditioned flavor preferences in rats and c-Fos analysis of the dopamine mesotelencephalic and nigrostriatal pathways following intake of sugars and fats in rats
<p>Systemic administration of the non-competitive NMDA antagonist, MK-801, demonstrated that acquisition, but not expression, were found to affect the orosensory-mediated (flavor/flavor: f/f) fructose-conditioned flavor preference (CFP). The present studies demonstrated a similar outcome when f/f …
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Length of Hospital Stay, Delirium and Discharge Status Outcomes Associated With Anticholinergic Drug Use in Elderly Hospitalized Dementia Patients
… or with inferred dementia based on ChEi or NMDA antagonist medication use) were studied using UHC clinical database. This document was created in Microsoft Word 2000. Results: Dementia patients on ChEi therapy were more likely to receive an ACh (chi-square 70.1, df=l, pConclusion: A person's …
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Testing the efficacy of LSN2463359, a metabotropic glutamate 5 receptor positive allosteric modulator, in animal models of schizophrenia
… glutamate levels resulting from hypofunction of NMDA receptors and hypoactivity of GABAergic neurons which normally inhibit glutamatergic cells in a tonic manner. Therefore, while traditional antipsychotics directly block dopamine receptors, some of the newly generated compounds are designed to …
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Effects of Dextromethorphan on Neurite Outgrowth and Marble Burying Behavior
… Alternative drug treatments acting on glutamate, NMDA receptors, and sigma-1, instead of serotonin, may be effective in treating OCD. One drug in particular, dextromethorphan (DM), provides antidepressant-like effects by possibly inhibiting glutamate and activating sigma-1 receptors. Common …
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Newly Synthesized Pyroglutamate Amide and its Neuroprotective Effect Against Neurotoxicity Induced Cell Death in Alzheimer's Disease
… activates extrasynaptic N-methyl-D-aspartate (NMDA) receptors and triggers pro-apoptotic signaling that overcomes synaptic NMDA receptors mediated survival signaling that is already undermined by other mechanisms such as the endocytosis of NMDA receptors leading to further synaptic damage by …
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The Effects of Early Postnatal PCP Administration on Performance in Locomotor Activity, Reference Memory, and Working Memory Tasks in C57BL/6 Mice
… that adults who abuse the noncompetitive NMDA antagonist PCP present with symptoms that mimic schizophrenia, such as hallucinations, formal thought disorder, delusions, unstable or flattened affect, social withdrawal, and impaired cognition. Thus, several labs have attempted to use early …
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Impact of Thalamocortical Synaptic Transmission on Input specific plasticity in Mouse Auditory Cortex
… The second project was to test the role of NMDA and GABAA receptors in TSMGBv-induced changes in thalamocortical fEPSPs. Microiontophoresis application of d-(-)-2-amino-5-phosphonovalerate (APV), a NMDAR antagonists and Bicuculline methiodide (BMI), a GABAA antagonists using multibarrel …
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Dissociated Antidepressant and Analgesic Effects of Intravenous Ketamine in Patients with Chronic Pain
연구 배경: 최근 연구들은 저용량의 케타민 치료가 수시간 혹은 수일 안에 우울 증상을 유의하게 호전시켰음을 증명해 왔다. 본 연구는 만성 통증 환자에서 케타민이 기분에 미치는 효과를 알아보고자 시행되었다. 연구 방법: 2013년 1월, 단일 기관에서 케타민 치료를 받는 통증클리닉 외래 환자 40명이 설문에 응하였다. The Beck Depression Inventory (BDI) 가 각 대상자의 기분을 평가하기 위해 사용되었고, 이후 케타민이 1시간에 걸쳐 모든 대상자에게 정맥 투여되었다 (평균 1.2mg/kg). 우울, 불안, …
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The effect of Alzheimer's disease on cortical microcircuits
… task. This analysis confirms that abnormal NMDA-channel function explains the neurophysiological deficit, more than AMPA or GABA channel changes. Alzheimer’s disease progressively changes NMDA channel time constants in primary auditory and inferior frontal regions. Chapter 6 examines the …
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Does distress predict central sensitisation in people living with HIV?
… related to CS, such as pain associated with HIV. NMDA antagonists are often used to prevent and treat pain associated with CS based on the evidence from animal and human pain studies. Evidence suggests that NMDA antagonists likely target mechanisms underlying clinical pain, specifically wind-up, …