Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 86 for “"NMDA Receptors"”.
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Targeting NMDA Receptors to Tune Corticothalamic Circuit Function
… revealed novel N-methyl-D-aspartate receptor (NMDAR) nucleus-specific and frequency-dependent functional diversity in the somatosensory CT circuit. Specifically, these findings illustrate the different effects of NMDAR negative modulation in the nRT and the VPM, which offers a method to …
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Pharmacology of a novel biased allosteric modulator for NMDA receptors
NMDA glutamate receptor is a ligand-gated ion channel that mediates a major component of excitatory neurotransmission in the central nervous system (CNS). NMDA receptors are activated by simultaneous binding of two different agonists, glutamate and glycine/ D-serine1. With aging, glutamate …
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Effects of Ifenprodil on the Gating or NR1/2B NMDA Receptors
… of the NR2 subunits differentially controls NMDA receptor activity. Ifenprodil binds to the ATD of NR1/NR2B receptors inhibiting the receptors. To delineate the effects of ifenprodil on NR1/NR2B receptor gating, we recorded steady state currents from cell attached and excised outside out …
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Identification of novel gating mechanisms underlying pharmacological potentiation of NMDA receptors
… mediated by N-methyl-D-aspartate receptors (NMDARs) is known to play an important role in synaptic plasticity, learning and memory. Moreover, NMDAR dysfunction may contribute to a variety of neuropsychiatric and neurological disorders including schizophrenia, epilepsy, stroke and …
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Distinct functional effects of NMDA receptors in normal and leukaemic megakaryocytes
… Ca2+-permeable N-methyl-D-aspartate receptors (NMDARs). Their involvement in megakaryocytic maturation has been shown in 2003 but details remain limited. The importance of Ca2+ homeostasis in malignant megakaryocytes has been further highlighted only in 2013 through the discovery of …
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A role for Dopamine neuron NMDA receptors in learning and decision-making
… predicted and actual reward. Knocking out NMDARs in dopamine neurons has been shown to attenuate dopaminergic phasic firing providing a potential model for delineating the functions of tonic and phasic dopamine. In order to study the role of dopamine neuron NMDARs in rewardcontingent …
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Critical requirements for NMDA receptors in experience-dependent plasticity in the visual cortex
NMDA receptors play an essential role in many forms of experience-dependent plasticity in the visual system. NMDA receptors support the ocular dominance (OD) shift, development of receptive field properties in cortical neurons, and learning tasks associated with the visual cortex, as well as the …
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Synaptic and extrasynaptic NMDA receptors in hippocampal neurons: regulation of nuclear shape and cell fate
… by inducing calcium influx through synaptic NMDA receptors. Calcium subsequently activates the ERK-MAP kinase cascades that transmits the signal from the synapse to the nucleus. A second mode for synapse-to-nucleus communication involves a propagating calcium signal that invades the cell …
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Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta
… increased excitatory activity in SNc-DA neurons. NMDA receptors (NMDARs) bind the excitatory neurotransmitter glutamate, and are essential for learning and memory. In SNc-DA neurons, NMDARs have a putative triheteromeric subunit arrangement of GluN1 plus GluN2B and/or GluN2D. Wild type (WT) mice, …
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The Contribution Of Nmda Receptors Within The Central Nucleus Of The Amygdala To The Suppression Of Pain Affect
… in response to noxious peripheral stimulation. NMDA receptors within CeA mediate this noxious-evoked neural excitation, and previous studies in the laboratory have shown that blockade of CeA NMDA receptors via the antagonist APV elevates the threshold for noxious tail-shock-induced vocalization …
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Role of GluN2C-containing NMDA Receptors in Cellular and Behavioral Deficits Associated with Corticothalamic Circuit Dysfunction in Schizophrenia
The NMDA receptor (NMDAR) hypofunction hypothesis in schizophrenia posits that reduced NMDAR function leads to behavioral abnormalities observed in schizophrenia. Lower expression of GluN2C subunit of NMDAR has been reported in the cortex and thalamus in postmortem brains from schizophrenic …
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The medial prefrontal cortex and the dorsomedial striatum are necessary for working memory in rats: role of NMDA receptors
… the contrbutions of N-methyl-D-aspartate (NMDA) receptors in medial prefrontal cortex (mPFC) and dorsomedial striatum (dmSTR) using two working memory tasks. The trial unique non-match to location (TUNL) task is a delayed-non-match-to-sample visual working memory task performed in …
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Leptin induces a novel form of long-term potentiation at the direct cortical input to hippocampal CA1 synapses
… CA1 synapses via activating postsynaptic NMDA receptors. In particular, leptin induces a long-term (P5-8) or transient (P11-18) depression of synaptic transmission that depends on GluN2B subunit-containing NMDA receptors in juvenile hippocampus, whereas leptin evokes long-term potentiation …
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The Structural Mechanism of Allosteric Modulation of The Nmda Receptor: A Balance of Tensions
<p>N-methyl-D-aspartate (NMDA) receptors are one of the three main types of ionotropic glutamate receptors in the central nervous system. NMDA receptors mediate the rapid excitatory neurotransmission that underlies learning and memory formation. Conversely, NMDA receptors are implicated in a …
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Potential for change: Characterizing synaptic plasticity following visual discrimination learning in adult rats.
… suggesting that training resulted in changes in NMDA receptor expression or functioning. Next, the effectiveness of LTD stimulation protocols to elicit synaptic depression under in vivo conditions were assessed. Of several single-pulse induction protocols tested, only strong low frequency burst …
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An Account of Chemical and Mechanical Regulation of TRPC6 Channels in Podocytes
… stimulation is mediated by surface-expressed receptors, and the roles of angiotensin II type 1 receptors (AT1R), insulin receptors, and N-methyl-D-aspartate receptors (NMDAR) on TRPC6 activity are studied here. In acutely isolated rat glomeruli, angiotensin causes an upregulation of TRPC6 …
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Ca2+ dependant synaptic modification
… thus controlling the opening of postsynaptic NMDA receptors and Ca2+ influx. By using this method, we found 1. that modification of synaptic strength has a bell-shaped dependency to the amount of Ca2+ influx, 2. that weak Ca2+ current through desensitized NMDA receptors sustained for a long …
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An analysis of morphological changes in visual cortical neurons after knocking down scaffolding proteins of glutamate receptors
NMDA receptor subunit changes have an important implication in synaptic development, learning, memory, and neuronal disorders. Previous studies have suggested that two membrane-associated guanylate kinase (MAGUK) family scaffolding proteins, SAP102 and PSD-95, are involved in the switch from …
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