Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 273 for “"NMDA"”.
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Agonist-Induced Conformational Changes In The Nmda Receptor
<p>NMDA receptors are ligand-gated ion channels that mediate a number of physiological and pathological phenomena within the mammalian central nervous system. Under the typical course of activation, these receptors bind to glycine and glutamate molecules and undergo a series of conformational …
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Targeting NMDA Receptors to Tune Corticothalamic Circuit Function
… revealed novel N-methyl-D-aspartate receptor (NMDAR) nucleus-specific and frequency-dependent functional diversity in the somatosensory CT circuit. Specifically, these findings illustrate the different effects of NMDAR negative modulation in the nRT and the VPM, which offers a method to …
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RABPHILIN3A: FROM NMDA RECEPTOR MEMBRANE DYNAMICS TO NEURODEVELOPMENTAL DISORDERS
… spines. It promotes the stabilization of the NMDA-type glutamate receptors (NMDARs) at the cell surface, forming a ternary complex with the PSD-95 and GluN2A subunit of the receptor. This complex is needed for long-term potentiation (LTP) induction and NMDAR-dependent hippocampal behaviors, …
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Functional role of NMDA receptor subunit composition in metaplasticity
… in the subunit composition and function of NMDA-type glutamate receptors (NMDARs). However, causality has not been conclusively established. Here we examined the mechanistic basis of metaplaticity, and specifically how this process is mediated by a switch in NMDAR subunit composition by …
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Probing spatial and subunit-dependent signalling by the NMDA receptor
NMDARs are ligand-gated cation channels which are activated by the neurotransmitter glutamate. NMDARs are essential in coupling electrical activity to biochemical signalling as a consequence of their high Ca2+ permeability. This Ca2+ influx acts as a secondary messenger to mediate neurodevelopment, …
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Pharmacology of a novel biased allosteric modulator for NMDA receptors
NMDA glutamate receptor is a ligand-gated ion channel that mediates a major component of excitatory neurotransmission in the central nervous system (CNS). NMDA receptors are activated by simultaneous binding of two different agonists, glutamate and glycine/ D-serine1. With aging, glutamate …
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Ειδικότητα Β λεμφοκυττάρων εγκεφαλονωτιαίου υγρού σε ασθενείς με μη παρανεοπλασματική αντι-NMDA εγκεφαλίτιδα / Cerebrospinal fluid B cell specificity in patients with non-paraneoplastic anti-NMDA encephalitis
… - N-μεθυλ-D-ασπαρτικού υποδοχέα εγκεφαλίτιδα (NMDARE) αποτελεί πρωτότυπο παράδειγμα αυτοάνοσης εγκεφαλίτιδας, η οποία χαρακτηρίζεται κυρίως από παρουσία αντισωμάτων ανοσοσφαιρίνης G1 (IgG1) που στοχεύουν την υπομονάδα GluNR1 του υποδοχέα NMDAR, προκαλώντας σοβαρή αλλά δυνητικά αναστρέψιμη …
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Distinct functional effects of NMDA receptors in normal and leukaemic megakaryocytes
… Ca2+-permeable N-methyl-D-aspartate receptors (NMDARs). Their involvement in megakaryocytic maturation has been shown in 2003 but details remain limited. The importance of Ca2+ homeostasis in malignant megakaryocytes has been further highlighted only in 2013 through the discovery of Calreticulin …
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Φυσιολογικός ρόλος του εναλλακτικού ματίσματος του υποδοχέα NMDA στο οπτικό σύστημα
… την ανάπτυξη του αμφιβληστροειδούς οι υποδοχείς NMDA συμμετέχουν σε φαινόμενα πλαστικότητας εξαρτώμενα από την εμπειρία όπως ο λειτουργικός διαχωρισμός των ON και OFF μονοπατιών. Η ανάπτυξη και η οπτική αποστέρηση επηρεάζουν επίσης τις ηλεκτροφυσιολογικές ιδιότητες των υποδοχέων NMDA στον …
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Effects of Ifenprodil on the Gating or NR1/2B NMDA Receptors
… of the NR2 subunits differentially controls NMDA receptor activity. Ifenprodil binds to the ATD of NR1/NR2B receptors inhibiting the receptors. To delineate the effects of ifenprodil on NR1/NR2B receptor gating, we recorded steady state currents from cell attached and excised outside out …
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Identification of novel gating mechanisms underlying pharmacological potentiation of NMDA receptors
… mediated by N-methyl-D-aspartate receptors (NMDARs) is known to play an important role in synaptic plasticity, learning and memory. Moreover, NMDAR dysfunction may contribute to a variety of neuropsychiatric and neurological disorders including schizophrenia, epilepsy, stroke and trauma. …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… are mediated via N-methyl D-aspartate receptor (NMDAR)-dependent signaling mechanisms. Inasmuch as neuronal activity involves activation of voltage-gated sodium channels (VGSCs) primarily, in this study, we used a sodium channel activator, brevetoxin-2 (PbTx-2) to mimic neuronal activity. …
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Chemical and stimulus-induced NMDA-dependent plasticity and the possible involved mechanisms
… by electric stimulation leading to activation of NMDA-R. Later research also revealed a form of NMDA-dependent plasticity induced by direct application of NMDA. I have investigated the involvement of AMPA-R and NMDA-R in NMDA-induced LTD as well as their contribution to early and late phases of …
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Role of NMDA in the Visual Working Memory of the Macaque Monkey
… that this persistent activity depends on NMDA receptor activation. Indeed, pharmacological studies on both human and animal subjects have reported a significant decrease in working memory task performance following the administration of NMDA-antagonists such as ketamine. However, the task …
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Vitamina C na retina: liberação por despolarização e regulação do receptor NMDA
… os receptores ionotrópicos de glutamato do tipo NMDA. A liberação da vitamina C é um tema muito divergente na literatura. Existem três hipóteses que explicam a liberação do ascorbato induzida pelo glutamato: heterotroca, participação de canais vasoativos e reversão do SVCT. Também existem …
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