Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 261 for “"NMDA"”.
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Agonist-Induced Conformational Changes In The Nmda Receptor
<p>NMDA receptors are ligand-gated ion channels that mediate a number of physiological and pathological phenomena within the mammalian central nervous system. Under the typical course of activation, these receptors bind to glycine and glutamate molecules and undergo a series of conformational …
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Targeting NMDA Receptors to Tune Corticothalamic Circuit Function
… revealed novel N-methyl-D-aspartate receptor (NMDAR) nucleus-specific and frequency-dependent functional diversity in the somatosensory CT circuit. Specifically, these findings illustrate the different effects of NMDAR negative modulation in the nRT and the VPM, which offers a method to …
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RABPHILIN3A: FROM NMDA RECEPTOR MEMBRANE DYNAMICS TO NEURODEVELOPMENTAL DISORDERS
… spines. It promotes the stabilization of the NMDA-type glutamate receptors (NMDARs) at the cell surface, forming a ternary complex with the PSD-95 and GluN2A subunit of the receptor. This complex is needed for long-term potentiation (LTP) induction and NMDAR-dependent hippocampal behaviors, …
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Functional role of NMDA receptor subunit composition in metaplasticity
… in the subunit composition and function of NMDA-type glutamate receptors (NMDARs). However, causality has not been conclusively established. Here we examined the mechanistic basis of metaplaticity, and specifically how this process is mediated by a switch in NMDAR subunit composition by …
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Probing spatial and subunit-dependent signalling by the NMDA receptor
NMDARs are ligand-gated cation channels which are activated by the neurotransmitter glutamate. NMDARs are essential in coupling electrical activity to biochemical signalling as a consequence of their high Ca2+ permeability. This Ca2+ influx acts as a secondary messenger to mediate neurodevelopment, …
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Pharmacology of a novel biased allosteric modulator for NMDA receptors
NMDA glutamate receptor is a ligand-gated ion channel that mediates a major component of excitatory neurotransmission in the central nervous system (CNS). NMDA receptors are activated by simultaneous binding of two different agonists, glutamate and glycine/ D-serine1. With aging, glutamate …
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Ειδικότητα Β λεμφοκυττάρων εγκεφαλονωτιαίου υγρού σε ασθενείς με μη παρανεοπλασματική αντι-NMDA εγκεφαλίτιδα / Cerebrospinal fluid B cell specificity in patients with non-paraneoplastic anti-NMDA encephalitis
… - N-μεθυλ-D-ασπαρτικού υποδοχέα εγκεφαλίτιδα (NMDARE) αποτελεί πρωτότυπο παράδειγμα αυτοάνοσης εγκεφαλίτιδας, η οποία χαρακτηρίζεται κυρίως από παρουσία αντισωμάτων ανοσοσφαιρίνης G1 (IgG1) που στοχεύουν την υπομονάδα GluNR1 του υποδοχέα NMDAR, προκαλώντας σοβαρή αλλά δυνητικά αναστρέψιμη …
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Φυσιολογικός ρόλος του εναλλακτικού ματίσματος του υποδοχέα NMDA στο οπτικό σύστημα
… την ανάπτυξη του αμφιβληστροειδούς οι υποδοχείς NMDA συμμετέχουν σε φαινόμενα πλαστικότητας εξαρτώμενα από την εμπειρία όπως ο λειτουργικός διαχωρισμός των ON και OFF μονοπατιών. Η ανάπτυξη και η οπτική αποστέρηση επηρεάζουν επίσης τις ηλεκτροφυσιολογικές ιδιότητες των υποδοχέων NMDA στον …
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Effects of Ifenprodil on the Gating or NR1/2B NMDA Receptors
… of the NR2 subunits differentially controls NMDA receptor activity. Ifenprodil binds to the ATD of NR1/NR2B receptors inhibiting the receptors. To delineate the effects of ifenprodil on NR1/NR2B receptor gating, we recorded steady state currents from cell attached and excised outside out …
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Identification of novel gating mechanisms underlying pharmacological potentiation of NMDA receptors
… mediated by N-methyl-D-aspartate receptors (NMDARs) is known to play an important role in synaptic plasticity, learning and memory. Moreover, NMDAR dysfunction may contribute to a variety of neuropsychiatric and neurological disorders including schizophrenia, epilepsy, stroke and trauma. …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… are mediated via N-methyl D-aspartate receptor (NMDAR)-dependent signaling mechanisms. Inasmuch as neuronal activity involves activation of voltage-gated sodium channels (VGSCs) primarily, in this study, we used a sodium channel activator, brevetoxin-2 (PbTx-2) to mimic neuronal activity. …
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Distinct functional effects of NMDA receptors in normal and leukaemic megakaryocytes
… Ca2+-permeable N-methyl-D-aspartate receptors (NMDARs). Their involvement in megakaryocytic maturation has been shown in 2003 but details remain limited. The importance of Ca2+ homeostasis in malignant megakaryocytes has been further highlighted only in 2013 through the discovery of Calreticulin …
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Role of NMDA in the Visual Working Memory of the Macaque Monkey
… that this persistent activity depends on NMDA receptor activation. Indeed, pharmacological studies on both human and animal subjects have reported a significant decrease in working memory task performance following the administration of NMDA-antagonists such as ketamine. However, the task …
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Vitamina C na retina: liberação por despolarização e regulação do receptor NMDA
… os receptores ionotrópicos de glutamato do tipo NMDA. A liberação da vitamina C é um tema muito divergente na literatura. Existem três hipóteses que explicam a liberação do ascorbato induzida pelo glutamato: heterotroca, participação de canais vasoativos e reversão do SVCT. Também existem …
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Fret-Based Investigations of The Structure-Function Relationships In The Nmda Receptor
<p>The <em>N</em>-methyl-D-aspartate (NMDA) receptor is one member of a class of proteins known as the ionotropic glutamate receptors. Ionotropic glutamate receptors mediate the majority of excitatory neurotransmission in the central nervous system, with the NMDA receptor standing out among these …
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