Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"NLRP6"”.
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Inflammasomes in the Intestinal Epithelium
… cytosolic pathogens. We have uncovered that NLRP6 may function to regulate intestinal mucus homeostasis and that disruption of this may underpin the diseases of the microbiota-gut-brain axis. Secondly, we have uncovered the importance of the non-canonical inflammasome and caspase-4 in …
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Examining the Role of Non-Canonical NOD-like Receptors and Inflammasomes in Inflammation and Disease
… of the non-inflammasome-forming NLR protein NLRP6, both at the cellular and biochemical level. Furthermore, using a pathogen-associated molecular pattern (PAMP)-driven model of inflammation, we sought to elucidate the function of the non-canonical caspase-4 inflammasome, particularly as it …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… the non-canonical inflammasome components NLRP6 and caspase 11. In further characterizing enteric neuronal populations, we identified a subset of intestinal CART+ neurons that were enriched in the distal intestine and modulated by the microbiota. Through microbial modulation strategies and …