Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 52 for “"NLRP3 inflammasome"”.
-
Fatty Acid Regulation of NLRP3 Inflammasome Activity
… inflammation that is driven in part by the NLRP3 inflammasome. This macromolecular complex responds to diverse danger signals by inducing secretion of inflammatory IL-1 family cytokines and promoting a type of cell death called pyroptosis. Saturated fatty acids (SFAs) are known to activate …
-
Role of the NLRP3 Inflammasome in bacterial keratitis
Purpose: Inflammasomes are key molecular regulators that play important roles in inflammation. Studies have reported that the NLRP3 inflammasome is activated in response to infection with Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). However, the role of NLRP3 …
-
The role of PLK1 in NLRP3 inflammasome activation
The NLRP3 inflammasome is a heteroprotein complex that assembles in response to a variety of DAMPs (Damage-Associated Molecular Patterns) and PAMPs (Pathogen-Associated Molecular Patterns). Activation of the NLRP3 inflammasome leads to pro-inflammatory cytokines (IL-1 and IL-18) release and …
-
The PLK1 and NLRP3 interactome in NLRP3 inflammasome activation
Excessive activation of the NLRP3 inflammasome is involved in sterile inflammation in multiple chronic diseases such as atherosclerosis, gout, type 2 diabetes or Alzheimer’s disease. However, current treatment strategies using generic targeting of IL-1, the end product of multiple inflammasome …
-
Expression and function of the NLRP3 inflammasome in Behçet’s disease
… 있을 것이라는 주장이 제기되고 있다. 최근 그람 음성균 감염 후 발생한 구내염 환자에서 NLRP3 inflammasome를 매개로 한 전신 염증의 가능성이 보고 되고 있으나 아직까지 베체트병에서 NLRP3 inflammasome의 역할에 대한 연구는 되어 있지 않다. 연구목적:이 연구는 베체트병에서 NLRP3 inflammasome 단백질의 발현 및 mRNA 의 발현을 말초혈액단핵구에서 확인하고 또한 LPS 와 ATP 자극에 따른 IL-1β 의 발현 양상을 알아보고자 했다. 재료 및 방법:활동성 베체트병 환자 (15명), …
-
Particulates Initiate Immune Response Via Inducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation
… liposomes. I hypothesize that liposomes activate NLRP3 inflammasome in macrophages, which results in the release of interleukin 1β (IL-1β), a proinflammatory cytokine that plays a key role in innate and adaptive immune responses.</p><p>To test my hypothesis, I determined the ability of inducing …
-
Analysis of the role of Pellino2 in the Activation of the NLRP3 Inflammasome.
… which controls IL-1β release is known as the inflammasome, which requires two signals to facilitate its activation. The work in this thesis demonstrates a role for the E3 ubiquitin ligase Pellino2 in the specific activation of the NLRP3 inflammasome. Using a newly generated Pellino2-deficient …
-
Pharmacological exploration of NLRP3 in Cardiovascular Diseases
Activation of NLRP3 inflammasome is essential for the development of many CVD. The NLRP3 inflammasome plays a clear role in different CVDs; however, because the aetiology, pathological characteristics, onset, and offset of these diseases are different, the inhibition of NLRP3 inflammasome and …
-
The Role of NLPR3 Inflammasome in Response to Thermal Injury and Sepsis
… increased risk of infection and sepsis. The NLRP3 inflammasome has established itself as an integral mediator of the acute phase response, however there is a current lack of understanding how it is involved in the inflammatory response after burn injury. In this study we investigated the role …
-
The Discovery of p62-dependent Processing Bodies
… able to <br/>recruit essential components of the NLRP3 inflammasome and therefore facilitate NLRP3 <br/>inflammasome formation and activation. This novel route to NLRP3 inflammasome <br/>activation through pd-PBs, which are formed during proteotoxic stress such as experienced <br/>11<br/>in NDDs, …
-
Investigating The Effect Of Chronic Muscle Use And Disuse On Innate Immune Signaling In Skeletal Muscle
… can activate innate immune pathways, such as the NLRP3 inflammasome complex, by augmenting the response against damage-associated molecular patterns (DAMPs). The objective of this study was to investigate how various metabolic conditions affect innate immune activation and mitochondrial health …
-
Modulatory effect of EVOO polyphenols and their metabolites on inflammatory response in Adenocarcinoma Colon Cells (Caco-2) and Human Umbilical Vein EC (HUVEC)
… as mitogen-activated protein kinases (MAPK) and NLRP3 inflammasome, which are linked to chronic inflammatory diseases. The alteration of epithelial/endothelial barrier in Caco-2 and HUVEC monolayers, treated with LPS or HG alone or together with EVOO phenolic compounds and their sulphate and …
-
MODELING AND MODULATING MYELOID CELL-MEDIATED NEUROINFLAMMATION FOLLOWING HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION
… the NLR family pyrin domain containing 3 (NLRP3) inflammasome pathway. We determined that treating HIV-infected iMg with CB2-specific agonists suppressed activation, but not priming, of the NLRP3 inflammasome, reducing IL-1β release. This combined work identified phenotypes and pathways …
-
Exploring the Role of the Inflammasome Pathway in Diabetic Retinopathy
… domain (NOD)-like receptor protein 3 (NLRP3) inflammasome activation, which orchestrates inflammation in the innate immunity, is associated with DR. However, the impact of inflammasome activation on DR progression remains uncertain. Therefore, this thesis seeks to investigate the role …
-
Entamoeba histolytica-induced Activation of Caspase-4 Regulates Gasdermin D Cleavage to Mediate IL-1β Secretion in Macrophages
… activates caspase-1 by the assembly of the NLRP3 inflammasome complex in a Gal-lectin and EhCP-A5-dependent manner, resulting in the maturation and secretion of IL-1β and IL-18. Pyroptosis, an inflammatory mode of lytic programmed cell death, is essential for host defence and other danger …
-
Unravelling the role of microbiome and Escherichia coli as a trigger for Inflammatory Bowel Disease with a particular focus on Crohn's disease.
… genes and molecular properties of E. coli with NLRP3 inflammasome activation, which may be a mechanism that causes CD. The microbiome analysis was based on 16 non-BD controls and 72 CD tissue samples. CD tissue samples consisted of tissues from active and inactive stages of disease; …
-
Unravelling the role of microbiome and Escherichia coli as a trigger for Inflammatory Bowel Disease with a particular focus on Crohn's disease.
… genes and molecular properties of E. coli with NLRP3 inflammasome activation, which may be a mechanism that causes CD. The microbiome analysis was based on 16 non-BD controls and 72 CD tissue samples. CD tissue samples consisted of tissues from active and inactive stages of disease; …
-
An investigation into the role of Pellino2 in lung inflammation
… with involvement of Pellino2 as a mediator in NLRP3 inflammasome-mediated IL-1β production whereas Pellino3 is without effect in this pathway. As Pellino2 was shown to play a role in the immune response following lung injury, the effect of Pellino2 deficiency on the inflammatory response during …
-
NLRP3 in Renal Injury and Inflammation
… resulting in fibrosis and kidney failure. The Nlrp3 inflammasome has been implicated in the innate immune response to cellular injury and represents a potentially important pathway in the pathogenesis of CKD. The central hypothesis of this thesis is that NLRP3 plays a significant role in renal …
Page 1 of 3