Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"NLRP3"”.
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The PLK1 and NLRP3 interactome in NLRP3 inflammasome activation
Excessive activation of the NLRP3 inflammasome is involved in sterile inflammation in multiple chronic diseases such as atherosclerosis, gout, type 2 diabetes or Alzheimer’s disease. However, current treatment strategies using generic targeting of IL-1, the end product of multiple inflammasome …
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NLRP3 in Renal Injury and Inflammation
… resulting in fibrosis and kidney failure. The Nlrp3 inflammasome has been implicated in the innate immune response to cellular injury and represents a potentially important pathway in the pathogenesis of CKD. The central hypothesis of this thesis is that NLRP3 plays a significant role in renal …
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Pharmacological exploration of NLRP3 in Cardiovascular Diseases
Activation of NLRP3 inflammasome is essential for the development of many CVD. The NLRP3 inflammasome plays a clear role in different CVDs; however, because the aetiology, pathological characteristics, onset, and offset of these diseases are different, the inhibition of NLRP3 inflammasome and …
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Fatty Acid Regulation of NLRP3 Inflammasome Activity
… inflammation that is driven in part by the NLRP3 inflammasome. This macromolecular complex responds to diverse danger signals by inducing secretion of inflammatory IL-1 family cytokines and promoting a type of cell death called pyroptosis. Saturated fatty acids (SFAs) are known to activate …
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Role of the NLRP3 Inflammasome in bacterial keratitis
… in inflammation. Studies have reported that the NLRP3 inflammasome is activated in response to infection with Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). However, the role of NLRP3 inflammasome in the pathogenesis of bacterial keratitis is not clearly understood. …
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The role of PLK1 in NLRP3 inflammasome activation
The NLRP3 inflammasome is a heteroprotein complex that assembles in response to a variety of DAMPs (Damage-Associated Molecular Patterns) and PAMPs (Pathogen-Associated Molecular Patterns). Activation of the NLRP3 inflammasome leads to pro-inflammatory cytokines (IL-1 and IL-18) release and …
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Expression and function of the NLRP3 inflammasome in Behçet’s disease
… 있을 것이라는 주장이 제기되고 있다. 최근 그람 음성균 감염 후 발생한 구내염 환자에서 NLRP3 inflammasome를 매개로 한 전신 염증의 가능성이 보고 되고 있으나 아직까지 베체트병에서 NLRP3 inflammasome의 역할에 대한 연구는 되어 있지 않다. 연구목적:이 연구는 베체트병에서 NLRP3 inflammasome 단백질의 발현 및 mRNA 의 발현을 말초혈액단핵구에서 확인하고 또한 LPS 와 ATP 자극에 따른 IL-1β 의 발현 양상을 알아보고자 했다. 재료 및 방법:활동성 베체트병 환자 (15명), …
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A Non-Canonical Function for NLRP3 and AIM2 in Kidney Diseases
NLRP3 and AIM2 are inflammasome-forming proteins that have been mostly studied in leukocytes. Canonical NLRP3 or AIM2 inflammasomes regulate cytokine maturation and pyroptosis via ASC and caspase-1 activation. Emerging studies demonstrate that NLRP3 or AIM2 is expressed in non-haematopoietic cells …
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Particulates Initiate Immune Response Via Inducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation
… liposomes. I hypothesize that liposomes activate NLRP3 inflammasome in macrophages, which results in the release of interleukin 1β (IL-1β), a proinflammatory cytokine that plays a key role in innate and adaptive immune responses.</p><p>To test my hypothesis, I determined the ability of inducing …
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Analysis of the role of Pellino2 in the Activation of the NLRP3 Inflammasome.
… Pellino2 in the specific activation of the NLRP3 inflammasome. Using a newly generated Pellino2-deficient mouse, it was determined that Pellino2 played no role during TLR induced NF-κB or MAPK signalling. However, Peli2-/- mice were more resistant to the lethal effects of LPS induced septic …
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The role of NLRP3 and AIM2 inflammasomes in dental pulp inflammation and reparative processes
… 2 (AIM2) and Nod-like receptor protein 3 (NLRP3) inflammasomes is yet to be elucidated. <br/><br/>In this thesis, the role of AIM2 and NLPR3 receptors was explored, both in bacterial and sterile inflammation context. Furthermore, the potential of modulating the inflammatory responses via …
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The Role of NLPR3 Inflammasome in Response to Thermal Injury and Sepsis
… increased risk of infection and sepsis. The NLRP3 inflammasome has established itself as an integral mediator of the acute phase response, however there is a current lack of understanding how it is involved in the inflammatory response after burn injury. In this study we investigated the role …
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The Discovery of p62-dependent Processing Bodies
… able to <br/>recruit essential components of the NLRP3 inflammasome and therefore facilitate NLRP3 <br/>inflammasome formation and activation. This novel route to NLRP3 inflammasome <br/>activation through pd-PBs, which are formed during proteotoxic stress such as experienced <br/>11<br/>in NDDs, …
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The role of inflammasomes in a murine model of acute respiratory distress syndrome (ARDS)
… proteins expressed in homeostatic and NLRP3-deficient lung tissue is not a key driver in the development of ARDS in this model. NLRP3 has a potential role in the resolution phase of lung injury because NLRP3 protein deficiency caused prolonged lung injury which was associated with …
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Expression of inflammasome-related molecules from U87MG cells cocultured with Naegleria fowleri in the non-contact system
… of the NOD-like receptor (NLR) family, such as NLRP3 and IPAF, and are defined by the NLR protein that they contain. The NLR protein recruits the inflammasome-adaptor protein, ASC, which in turn interacts with caspase-1 leading to its activation. Consequently caspase-1 promotes the maturation of …
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Inflammasome mediated response to biomaterials implanted in the peripheral nervous system
… dexamethasone (used as positive control) and NLRP3 inflammasome inhibitor (proposed intervention). I have demonstrated that localised delivery of a NLRP3 inhibitor reduces FBR scar thickness (at 3 months), without reduction in axonal count. This also corresponded with a possible reduction in …
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Investigating the Contribution of the Inflammasome to Persistent Pain States
… protein (eg nod-like receptor-1 (NLRP1), NLRP3), the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC), and pro-caspase-1. It is known to assemble in response to a variety of exogenous and endogenous danger signals (eg adenosine-5’-triphosphate (ATP), …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
… that simultaneous activation of TLRs and NLRP3, which likely mimics natural infection by pathogenic microbes, triggers rapid caspase-1 cleavage, release of alarmins and pyroptosis. This acute caspase-1 activation is independent of new protein synthesis and depends on the TLR signaling …
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Entamoeba histolytica-induced Activation of Caspase-4 Regulates Gasdermin D Cleavage to Mediate IL-1β Secretion in Macrophages
… activates caspase-1 by the assembly of the NLRP3 inflammasome complex in a Gal-lectin and EhCP-A5-dependent manner, resulting in the maturation and secretion of IL-1β and IL-18. Pyroptosis, an inflammatory mode of lytic programmed cell death, is essential for host defence and other danger …
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