Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"NLRP1"”.
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Perfil de expressão de genes relacionados a doenças autoimunes/inflamatórias em indivíduos com síndrome de down
… estudo avaliou o perfil de expressão dos genes NLRP1, NLRP3, IL-1β, CTLA-4 e PTPN22 em indivíduos com SD suscetíveis ao desenvolvimento de doenças autoimunes/inflamatórias. Além disso, avaliamos se os pacientes com SD apresentam resposta inflamatória diferencial dos genes do inflamassoma após …
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Elucidating the Role of Pattern Recognition Receptors in Understanding, Treating, and Targeting Cancer
… and cancer. Mice lacking a specific NLR, NLRP1, are more susceptible to chemically induced colitis and colitis-associated tumorigenesis. We investigated whether the absence of NLRP1 in the gastrointestinal tract influenced the composition of the microbiome, and whether it was responsible …
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Rodent inflammasome activation by Toxoplasma gondii
… to the secretion of IL-1[beta] in vitro. The NLRP1 and NLRP3 inflammasomes play a major role in mouse survival and control of parasite replication in vivo. The NLRPI inflammasome is activated in infected macrophages from rats that are able to completely clear infection. Toxoplasma infection …
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Investigating the Contribution of the Inflammasome to Persistent Pain States
… scaffold protein (eg nod-like receptor-1 (NLRP1), NLRP3), the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC), and pro-caspase-1. It is known to assemble in response to a variety of exogenous and endogenous danger signals (eg adenosine-5’-triphosphate (ATP), …
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Investigation of DNA variation in genes of the immune system in wild populations of Apodemus sylvaticus in relation to infection by Toxoplasma gondii and helminth parasites
… the parasite Toxoplasma gondii. Furthermore, the NLRP1b gene, a key component in regulating inflammation during infection, her been found in laboratory studies to be responsible for resistance of the mice against toxoplasmosis. Also, it is located at the Toxo1 locus which has been shown to be a …