Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"NLRC4 inflammasome"”.
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Transcriptional Regulation of NLRC4 Inflammasome by IRF8
<p>The NLRC4 inflammasome is a crucial part of the innate immune response against bacterial infections. We found that NLRC4 inflammasome activation in bone marrow-derived macrophages (BMDMs) is greatly dependent on interferon regulatory factor 8 (IRF8). NLRC4-mediated caspase-1 activation and …
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Molecular basis of NAIP/NLRC4 inflammasome activation by flagellin
… Typhimurium (S. Typhimurium) activates the NAIP/NLRC4 inflammasome and its contribution to the host protective immune response against salmonellosis. Inflammasomes are multi-protein complexes formed in response to the activation of pattern recognition receptors (PRRs). The NOD-like receptor …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
… maturation mediated by the activation of the inflammasome complex. In order to study the comprehensive role of BRD4 in cytokine production, we seek to investigate if BRD4 plays a role in regulating inflammasome activation and cytokine maturation. Using Salmonella enterica serovar Typhimurium …
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Intracellular triggering of inflammation by the extracellular bacterium Pseudomonas aeruginosa
… protein complexes, the Nod-signalosome and inflammasomes. These lead to the activation of NF-κB and the activation of caspase-1 and subsequent proteolytic processing of interleukin-1β (IL-1β) into its mature form. Both processes contribute to the inflammatory response following infection. In …
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Caspase isoforms in inflammasome activation
Inflammasomes are macromolecular signalling platforms composed of a receptor (for example NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the …