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Showing 1 to 4 of 4 for “"NKX6.1"”.
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New Roles of the Transcription Factor NKX6.1 in Beta Cell Biology
… of the homeodomain transcription factor Nkx6.1 was found to be positively correlated with the capacity for GSIS in these lines. Although previously identified as an essential factor for beta cell differentiation, little was known about the function of Nkx6.1 in mature beta cells. The …
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Proteomic Characterization of Human Multipotent Stromal Cells Secreted Proteins with Therapeutic Potential for β-cell Regeneration
… injection, followed by α-β-cell conversion with NKX6.1-expression in transitioning β-cells, and augmented β-cell proliferation to generate functionally mature neoislets that respond to glucose. Altogether, these studies provide an extraordinary view of how this dynamic cell type can be used in …
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Regulating Distinct Cell Lineages in the Pancreatic Islet
… as a decrease in the β cell markers, NeuroD, Nkx6.1, Ins1 and Ins2. However, there is no change in α cell numbers or the α cell markers, Glucagon and Irx2. Unlike the persistent upregulation of Ghrelin in the Nkx2.2 mice, Nkx2.2SD/SD mice display a transient increase in Ghrelin expression, …
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Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of …