Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"NKX2-1"”.
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The Genome-Wide Roles of The Lung Lineage Transcription Factor Nkx2-1 In The Regulation of Opposing Cell Fates In Vivo
… lineage transcription factor NK Homeobox 2-1 (NKX2-1) is expressed throughout the lung epithelium during development and was thought to be lost in the extraordinarily thin cell type required for gas exchange– the alveolar type 1 (AT1) cell. Complementing precise genetic knockouts with cell …
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Transcriptional regulation of metastatic progression in lung adenocarcinoma
… inhibited by three transcription factors - Nkx2-1, Foxa2, and Cdx2. These three factors were highly expressed in non-metastatic cells, and downregulated in metastatic cells. Altered expression of these factors led to commensurate changes in Tks5long levels. Finally, we demonstrated that …
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The Role of the Transcription Factor CEBPA in Regulating Lung Alveolar Type 2 Cell Fate In Vivo
… program and recruiting the lineage-specific TF NKX2-1. Without CEBPA, AT2 cells, in both neonatal and mature, show a diminished AT2 program; however, only neonatal cells re-activate the SOX9 progenitor program. Intriguingly, mature AT2 cells exhibit neonatal-like plasticity under Sendai virus …
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An In Vivo Functional Genomics Screen Identifies New Regulators of Tumorigenesis in Non-Small Cell Lung Cancer
… however FOXA1 was found to be co-amplified with NKX2-1 on chromosome 14q. Here we report that NSCLC cell lines and tumor samples have significantly higher FOXA1 expression compared to normal lung epithelial cells and tissues, and that 14q-amplified NSCLC cell lines are preferentially dependent on …