Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"NKT cells"”.
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CD1d restricted NKT cells in regulation of pathogenic autoimmunity
… (AIA) – models for RA. A sub-population of T cells, termed natural killer T cells (NKT), have been suggested as having immunoregulatory features in pathogenic autoimmunity. How NKT cells are activated to perform this regulation and by which functional pathways they act is not completely …
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Identification of rat NKT cells and molecular analysis of their surface receptor mediated activation
Zusammenfassung NKT Zellen wurden ursprünglich über die gleichzeitige Expresion eines T-Zellantigenrezeptors (TZR) und den NK-Zellmarkern NKRP1A im Menschen bzw. NK1.1. (NKRP1C) in der Maus definiert. In Mensch und Maus exprimieren die meisten NKT Zellen CD1d restringierte TZR mit …
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The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
… in UM patients. We have previously shown that NKT cell-deficient mice develop significantly fewer liver metastases from intraocular melanomas than do wild-type (WT) mice. Here, we examine the interplay between liver NKT cells and NK cells in resistance to liver metastases from intraocular …
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Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease
… organ damage mediated by dysregulated donor T cells. Preclinical studies have shown invariant natural killer T cells (iNKT) cells can prevent GVHD while preserving GVL. iNKT cells are unconventional T cells which recognize glycolipid antigens presented in the context of CD1d. Upon activation, …
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Immuno-modulatory functions of CD1d-restricted natural killer T cells
… T lymphocytes, called natural killer T (NKT) cells. NKT cells have many unique features; such as recognition of glycolipids presented by CD1d, expression of NK receptors and rapid production of large amounts of cytokines, such as IL-4 and IFN-gamma,?upon activation. This early and robust …
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Natural killer T cell subsets and regulation of autoimmune diabetes
This thesis is focused on natural killer (NK) T cells. NKT cells recognize lipids and glycolipids, rather than peptides, in the contents of the antigen presenting molecule CD1d. NKT cells have a surface phenotype reminiscent of memory cells, and have been shown to rapidly produce large amounts of …
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The Influence of Immunization Route On The Adjuvant Effect of Alpha-Galactosylceramide
… activates the innate immune mediating NKT cells to produce cytokines and activate downstream immune cells, resulting in development of humoral and cell mediated immune responses to co-administered antigens. While a single intravenous immunization of α-GalCer strongly activates NKT …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… syndrome marked by apoptosis of CD4+ T cells, a weak CD4 Th1 response, and overproduction of TNF-alpha and IL-10. C57BL/6 mice were inoculated intradermally or intraperitoneally with IOE, models that closely reproduce the pathology and immunity associated with tick-transmitted HME, or …
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Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… was manifested in terms of potent activation of NKT cells, an important innate immunity mediator, along with the activation of dendritic cells (DC) which serve as the professional antigen-presenting cells. Data from this investigation provide the first evidence for mucosal delivery as an …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… components of the plasma membrane of eukaryotic cells. They serve in many regulatory capacities and have antigenic properties towards natural killer T (NKT) cells of the innate immune system. Critical to the recognition of glycosylceramides by NKT cells are antigen presenting cells (APC), such as …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… normal maturation and activation of B and T cells. Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody dependent cellular cytotoxicity (ADCC) of human NK cells. In this study, I show that Vav-1 is also expressed in murine NK cells. …
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Protective Immunity in Atherosclerosis
… by immunosuppressive regulatory T cells (Tregs). Immunizations of hypercholesterolemic mice with oxidized LDL or peptides derived from the protein part of LDL, apoB-100, inhibit the development of atherosclerosis. The protective immunity induced by the apoB-100 peptide vaccine …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening of lymphocyte subsets in splenocytes and in peripheral blood. Genetic mapping and sequencing identified the two mutations. The first was a …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening of lymphocyte subsets in splenocytes and in peripheral blood. Genetic mapping and sequencing identified the two mutations. The first was a …
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Cellular Immune Changes in the Peripheral Blood of Subjects Chronically Infected with XMRV
… CD3- lymphocytes, CD45+ CD3- CD19- CD56+ NK cells and CD19+ B cells. Moreover, the NK phenotype in XMRV+ patients was altered, with 80% of XMRV+ patients having a significantly reduced CD56DIM population. Within this CD56DIM population present in XMRV+ patients, only 40% express CD16. XMRV …
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Using Mice with Conditional Deletion of the IFNg Receptor to Identify the Cellular Targets of IFNg during Development of Anti-Listeria Immune Responses
… but the identities and roles of IFNg responsive cells that initiate this process remain unclear. In this thesis, unique mice displaying conditional loss of the IFNg receptor: Ifngr1f/f mice) in different tissues have been generated and used to explore the role of this cytokine in initiating the …
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A study of invariant NKT cell biology in health and disease
Invariant NKT cells (iNKT cells) have been increasingly recognised as an important cell type in regulating certain immune responses. Advances in the understanding of iNKT biology have provided opportunities for manipulating their functions for combating malignant, infective and autoimmune diseases. …
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus (SLE), a prototypic systemic humoral autoimmune disease. However, the cellular events that stimulate the development of …
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Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System
… a breakdown of immunological tolerance in CD4 cells. The aim of this thesis is to improve our understanding of regulation mechanisms of T cell-dependent chronic inflammation in the CNS and explore ways to overcome the onset and progression of the disease, which can be an important step forward …
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