Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"NKT cell"”.
-
A study of invariant NKT cell biology in health and disease
Invariant NKT cells (iNKT cells) have been increasingly recognised as an important cell type in regulating certain immune responses. Advances in the understanding of iNKT biology have provided opportunities for manipulating their functions for combating malignant, infective and autoimmune diseases. …
-
The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
… in UM patients. We have previously shown that NKT cell-deficient mice develop significantly fewer liver metastases from intraocular melanomas than do wild-type (WT) mice. Here, we examine the interplay between liver NKT cells and NK cells in resistance to liver metastases from intraocular …
-
Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… components of the plasma membrane of eukaryotic cells. They serve in many regulatory capacities and have antigenic properties towards natural killer T (NKT) cells of the innate immune system. Critical to the recognition of glycosylceramides by NKT cells are antigen presenting cells (APC), such as …
-
Natural killer T cell subsets and regulation of autoimmune diabetes
This thesis is focused on natural killer (NK) T cells. NKT cells recognize lipids and glycolipids, rather than peptides, in the contents of the antigen presenting molecule CD1d. NKT cells have a surface phenotype reminiscent of memory cells, and have been shown to rapidly produce large amounts of …
-
Immuno-modulatory functions of CD1d-restricted natural killer T cells
… T lymphocytes, called natural killer T (NKT) cells. NKT cells have many unique features; such as recognition of glycolipids presented by CD1d, expression of NK receptors and rapid production of large amounts of cytokines, such as IL-4 and IFN-gamma,?upon activation. This early and robust …
-
The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… normal maturation and activation of B and T cells. Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody dependent cellular cytotoxicity (ADCC) of human NK cells. In this study, I show that Vav-1 is also expressed in murine NK cells. …
-
Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment of Genital Hpv Tumors
… employing the combination of TLR9 and NKT cell ligands, (CpG-ODN and α-GalCer, respectively) will induce potent systemic and mucosal antigen-specific CD8 T cell response, specifically at the female reproductive tract (FRT) to eliminate HPV genital tumors.</p> <p>Utilizing an orthotopic …
-
The Influence of Immunization Route On The Adjuvant Effect of Alpha-Galactosylceramide
… activates the innate immune mediating NKT cells to produce cytokines and activate downstream immune cells, resulting in development of humoral and cell mediated immune responses to co-administered antigens. While a single intravenous immunization of α-GalCer strongly activates NKT …
-
Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model
… favorable response in pancreatic cancer cell lines, alone and in combination with Gemcitabine. In this study, we investigated the <em>invivo</em> effects of dietary Garcinol in a transgenic mouse model of Pancreatic Cancer (PaCa). This model is considered to be the animal model which best …
-
Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease
… for hematologic malignancies is allogeneic stem cell transplantation (ASCT), in which the patient’s immune system is replaced with that of a healthy donor. This can lead to cure through the graft versus leukemia (GVL) effect but can also cause graft versus host disease (GVHD), which is …