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Showing 1 to 20 of 40 for “"NKT"”.
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Immunbiologie hepatischer Natürlicher - Killer T- (NKT-) Zellen
… Wahrscheinlich sind Natürlichen Killer T- (NKT-) Zellen, wesentlich an dieser Regulation von Toleranz und Immunität beteiligt. Deshalb war das Ziel dieser Arbeit, zum Verständnis der Rolle beizutragen, die NKT - Zellen innerhalb des immunologischen Mikromilieus der Leber spielen. Es zeigten …
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CD1d restricted NKT cells in regulation of pathogenic autoimmunity
… of T cells, termed natural killer T cells (NKT), have been suggested as having immunoregulatory features in pathogenic autoimmunity. How NKT cells are activated to perform this regulation and by which functional pathways they act is not completely understood. A number of natural antigens …
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A study of invariant NKT cell biology in health and disease
Invariant NKT cells (iNKT cells) have been increasingly recognised as an important cell type in regulating certain immune responses. Advances in the understanding of iNKT biology have provided opportunities for manipulating their functions for combating malignant, infective and autoimmune diseases. …
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Identification of rat NKT cells and molecular analysis of their surface receptor mediated activation
Zusammenfassung NKT Zellen wurden ursprünglich über die gleichzeitige Expresion eines T-Zellantigenrezeptors (TZR) und den NK-Zellmarkern NKRP1A im Menschen bzw. NK1.1. (NKRP1C) in der Maus definiert. In Mensch und Maus exprimieren die meisten NKT Zellen CD1d restringierte TZR mit …
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The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
… in UM patients. We have previously shown that NKT cell-deficient mice develop significantly fewer liver metastases from intraocular melanomas than do wild-type (WT) mice. Here, we examine the interplay between liver NKT cells and NK cells in resistance to liver metastases from intraocular …
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Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease
… have shown invariant natural killer T cells (iNKT) cells can prevent GVHD while preserving GVL. iNKT cells are unconventional T cells which recognize glycolipid antigens presented in the context of CD1d. Upon activation, they secrete cytokines according to the functional subtypes NKT1, NKT2, …
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Immuno-modulatory functions of CD1d-restricted natural killer T cells
… T lymphocytes, called natural killer T (NKT) cells. NKT cells have many unique features; such as recognition of glycolipids presented by CD1d, expression of NK receptors and rapid production of large amounts of cytokines, such as IL-4 and IFN-gamma,?upon activation. This early and robust …
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Natural killer T cell subsets and regulation of autoimmune diabetes
… is focused on natural killer (NK) T cells. NKT cells recognize lipids and glycolipids, rather than peptides, in the contents of the antigen presenting molecule CD1d. NKT cells have a surface phenotype reminiscent of memory cells, and have been shown to rapidly produce large amounts of …
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The Influence of Immunization Route On The Adjuvant Effect of Alpha-Galactosylceramide
… activates the innate immune mediating NKT cells to produce cytokines and activate downstream immune cells, resulting in development of humoral and cell mediated immune responses to co-administered antigens. While a single intravenous immunization of α-GalCer strongly activates NKT …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… antigenic properties towards natural killer T (NKT) cells of the innate immune system. Critical to the recognition of glycosylceramides by NKT cells are antigen presenting cells (APC), such as dendritic cells, which are responsible for binding, processing, and delivery of ligands to these …
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Interaktionen von dendritischen Zellen und Effektorzellen der frühen antitumoralen Immunabwehr
… und aktivierend auf T-Lymphozyten wirkt. Funktionelle Analysen ergaben, dass aktivierte slanDCs das zytotoxische Potential von NK-Zellen gegenüber der Tumorzelllinie K-562 deutlich verstärken. Untersuchungen der zugrunde liegenden Mechanismen zeigten die herausragende Bedeutung von IL-12, …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… cells, and decreased numbers of hepatic NKT cells. Mice infected intraperitoneally with IOE had increased splenic and hepatic numbers of CD11b+ cells, increased hepatic CD4+ and CD8+ T cells, and decreased splenic CD4+ T cells. Because of the observed differences in NKT cells, I …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… is normal in Vav-1-/- mice, their numbers of NKT cells were dramatically diminished. Furthermore, NKT cells from Vav-1 mutant mice failed to produce IL-4 and IFNg following in vivo CD3 stimulation. A similar loss of NKT cells was observed in Vav-1-/-Vav-2-/- mice, but not in Vav-2-/- mice, …
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Entry-Level Physical Therapy Students' Knowledge and Attitudes of Nutrition
… Surveys, included a nutrition knowledge test (NKT) (32 possible points) and an attitudes scale (55 possible points) and were disseminated by doctoral physical therapy program directors to students in various programs. The mean attitude score of this sample (N=605) was 47.13 ± 4.32. The mean NKT …
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Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… was manifested in terms of potent activation of NKT cells, an important innate immunity mediator, along with the activation of dendritic cells (DC) which serve as the professional antigen-presenting cells. Data from this investigation provide the first evidence for mucosal delivery as an …
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Protective Immunity in Atherosclerosis
… presentation is required for activation of NKT cells. The role of MHC class II antigen presentation in atherosclerosis is complex and was unexpectedly found to be associated with reduced atherosclerosis development, whereas, neointima formation in response to vascular injury was accelerated …
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Cellular Immune Changes in the Peripheral Blood of Subjects Chronically Infected with XMRV
… showed a important increase in CD3+ CD56+ NKT cells with a NK to NKT ratio that was 55% higher than XMRV- healthy controls. The B cells present in the peripheral blood of XMRV+ CFS patients contained a remarkable CD20+, CD23+ mature B cells. The myeloid cell compartment showed an increased …
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Using Mice with Conditional Deletion of the IFNg Receptor to Identify the Cellular Targets of IFNg during Development of Anti-Listeria Immune Responses
… production is derived from TNFa-activated NK/NKT cells. These mice survived Listeria infection due to a second wave of IL-12 produced by other myeloid cells.</p><p>Next, Ifngr1f/f mice were bred with LysM-cre mice to obtain myeloid cell specific Ifngr1 deletion. LysM-cre+Ifngr1f/f mice lacking …
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CD8+ lymphocyte and progenitor cell mobilization during acute psychological stress and betaadrenergic stimulation
… the stress reactivity of CD8TLs, CD4TLs and NKT-like cells. Chapter 4 examined whether antigen-specificity could modulate CD8TL stress- and \(\beta\)AR-sensitivity. CMV-specific cells demonstrated enhanced mobilization compared to the total-memory CD8TL and the total Epstein-Barr virus (EBV) …
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