Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"NKG2D"”.
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NKG2D Ligands in Cancer
… have not been well elucidated. Because NKG2D is a major activating receptor on NK cells, we sought to test the hypothesis that NKG2D is the primary pathway in tumor cell recognition. Herein, we comprehensively assessed 20 cancer cell lines representing a broad array of cancer types. In …
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Simultaneous Induction of Nkg2D and Nkg2D Ligand For Promoting Immune Surveillance By Il-12 Plus Doxorubicin Treatment
<p>NKG2D (natural killer group 2, member D) and its ligands interaction in tumor microenvironment directs tumor infiltrating immune cells to recognize tumor cells, stimulate cytotoxic effector immune cells, and therefore eradicate tumor cells. IL-12, a cytokine produced by antigen presenting cells, …
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THE ROLE OF INTERFERON REGULATORY FACTORS IN REGULATING THE EXPRESSION OF NKG2D LIGANDS
… mechanisms. It has been previously shown that NKG2D ligands are upregulated by the DDR in a p53-independent manner. We provide evidence in this study that the upregulation of NKG2D ligand expression in response to DNA damage depends on the serine/threonine kinase TBK1 and its phosphorylation …
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Characterization of NKG2Dmediated signaling pathways and its role in the regulation of cell migration
NKG2D es un receptor transmembrana expresado principalmente en células NK y T CD8+. Se asocia a la proteína DAP10 para la transducción de señales, la cual contiene un motivo de señalización YINM, similar al de la molécula CD28. Los ligandos de NKG2D en humanos son MICA, MICB y las ULBP1-5, cuya …
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Regulation of Fluid-phase Uptake in Podocytes by Albumin-associated Lipids
… have previously shown that interaction between NKG2D (natural-killer group 2, member D) and its ligand Rae-1ɛ is sufficient to recruit cytotoxic T lymphocytes to the pancreas and induce insulitis. Here, we tested to see whether NKG2D-NKG2D ligand interaction is also involved in obesity-induced …
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Combination Therapy With Aerosol Il-2 and Nk Cells For The Treatment of Osteosarcoma Lung Metastasis
… osteosarcoma lung metastasis. The expression of NKG2D ligands was analyzed in five different human osteosarcoma cell lines and 103 patient samples (47 from primary tumors and 56 from lung metastases). We discovered that osteosarcoma expresses the ligands for the NKG2D. <em>In vitro</em> studies …
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Die Regulation von humanen Natürlichen Killerzellen : regulierte SAP-Expression und die Rolle der Lipid Rafts
… zu der Vermutung führten, dass der aktivierende NKG2D-Rezeptor die Signale der MHC Klasse I-bindenden, inhibierenden Rezeptoren übergehen könnte und trotz der MHC-Klasse I Expression der Zielzellen deren Lyse durch die NK Zellen induziert. In dieser Arbeit wurde zum einen das Wechselspiel …
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Role of Stat3 In Human Nk Cell Functions
… of STAT3 in the transcriptional regulation of NKG2D, a primary activating NK receptor. Based on these findings, I hypothesized that STAT3 signaling plays a critical role in human cytolytic function and proliferation.</p> <p>I analyzed NK cells from Job syndrome patients to test my hypothesis. …
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Identification of Markers to Predict Benefit from Trastuzumab Treatment
… profile, characterised by high expression of the NKG2D receptor. Enrichment of immune system- and tyrosine kinase receptor signaling-related pathways was found associated also with response to trastuzumab monotherapy in clinical samples, suggesting the possibility to treat HER2-addicted tumours …
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In vivo and in vitro studies of immunodeficiency in Ataxia-telangiectasia
… via DNA damage-induced upregulation of NKG2D ligands. My results confirm a deficiency in naive T and B cells as well as high expression of the death receptor CD95 on all lymphocyte subsets excluding NK cells which together may explain the lymphopaenia in A-T. Analysis of the sensitivity …
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Immune Control of Hepatitis B Virus infection by innate lymphocytes
… of the cytotoxicity-associated receptor NKG2D by V2 T cells which may be another mechanism by which immune-mediated damage is limited in these HBV patients. Furthermore, we have found that HBV proteins have negative effects on IFN--production by V2 T cells suggesting that HBV can …
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… of IRF3 induced the expression of ligands for NKG2D, which regulates the ability of immune cells to recognize and eliminate tumors. Finally, we found that the DNA sensor Z-DNA binding protein (ZBP1) regulates B-cell lymphomagenesis. In summary, the data suggest pathogen recognition systems play …
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The Role of Gammadelta T Cells and CD8+ Memory T Cells in Vaccinia Viral Infection
… to conventional expectations, we found that NKG2D expression in both NK and CD8+ T cells only have partial effect on the elimination of VV post-infection. Instead, we found that NKG2D is an important activator of gammadelta T cell cytotoxicity for VV clearance. Lastly, we demonstrated that …
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The role of miRNA-486-5p in hair growth and the hair follicle immune privilege
… with a higher number of intrafollicular NKG2D+ cells in C3H/HeJ mice. Silencing of miR-486-5p in human anagen HFs ex vivo caused premature catagen development and led to suppression of IP by up-regulating HLA class 1, IRF1, ICAM1 and CADM1 expression of which CADM1 was confirmed to be a …
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The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies
… B cells also upregulate Rae-1, a ligand for the NKG2D activating receptor found on natural killer (NK) cells, which renders them sensitive to NK attack. Furthermore, I demonstrated that IgH/c-myc translocations can be detected in vivo in germinal center (GC) B cells of immunized mice, and that …
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The Biology of Mantle Cell Lymphoma: Exploring the Gender Difference in Mantle Cell Lymphoma
… activating receptors; NKp46, NKp44, NKp30 and NKG2D were examined to determine if their expression was different between the genders. The cell mediated cytotoxic function of the immune cells (PBMCs) from male and female MCL patients and healthy controls was also examined. Interestingly the …
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Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy
… helper virus. Oncolytic virotherapy can recruit NKG2D bearing NK or T cells to the tumor site, and the simultaneous release of these chimeric engagers by the co-delivered amplicons mediate cytotoxicity against tumor cells by crosslinking them with the immune cells via the overexpressed EGFR. …