Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"NK1R"”.
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Spinal cord plasticity in peripheral inflammatory pain
… that lamina I neurokinin 1 receptor expressing (NK1R+) spinal cord output neurons are crucial for the manifestation of inflammatory pain. There is also evidence that the afferent input to and the postsynaptic response of these neurons may be altered in inflammatory pain, which could be relevant …
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The role of substance P in experimental intracerebral haemorrhage.
… of antagonists to the main substance P receptor (NK1R), using functional testing, histological analysis, ELISA, real-time RT-PCR, wet-weight dry weight (for assessment of oedema) and Evans blue (for assessment of blood-brain barrier integrity). The effect of prior splenectomy on oedema following …
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Role of neurogenic inflammation in the pathogenesis of acute pancreatitis and associated lung injury
… caerulein-induced AP in mouse were investigated. NK1R antagonist, CP96,345, significantly reduced the severity of AP and associated lung injury. Present study demonstrated that CP96,345 treatment affected the release of substance P (SP), the expression of neurokinin receptor and tachykinin genes, …
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Mild traumatic brain injury augments innate immune responses through neurokinin and cholinergic signaling
… Using an FDA-approved neurokinin-1 receptor (NK1R) antagonist, aprepitant, we confirmed our previous findings that substance P (SP) is a key mediator of enhanced resistance to pneumonia. Blocking NK1R showed that mTBI-induced release of SP augments pulmonary neutrophil recruitment and …
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Spinothalamic tract neurons in laminae I, III and IV of the rat: a retrograde neuronal tracing study
… cord that express the neurokinin 1 receptor (NK1r) and have prominent dorsal dendrites that enter the superficial laminae. A substantial body of evidence points to the involvement of this population of cells in processing various types of noxious stimulus. Neurons of this type in lumbar …