Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"NK1"”.
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L'infiammazione intestinale nell'animale sperimentale come modello per lo sviluppo di nuovi farmaci: ruolo della via tachichininergica nelle malattie infiammatorie intestinali
… action through three distinct receptors, termed NK1, NK2 and NK3. SP modulates intestinal motility and enteric secretion, acting preferentially through the NK1 receptor. SP neural network and NK1 receptor expression are increased in patients with inflammatory bowel disease, and similar changes …
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A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain
… colonic DRG neurons. Immunoreactivity for the SP NK1 receptor on second order neurons was also examined and a significant increase in immunoreactivity was observed on post-synaptic second order cell bodies following chronic DSS. This could provide an additional mechanism for enhanced SP …
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The role of substance P in experimental intracerebral haemorrhage.
… Inhibiting the main SP receptor (neurokinin-1 (NK1)) reduces oedema and improves functional outcome in both settings. As this thesis details, we hypothesised that SP plays a similarly deleterious role following intracerebral haemorrhage (ICH). We further hypothesised that the post-ICH effects of …
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Neurokinin-1 antagonism as a novel treatment for feline asthma : investigation of the role of substance p in airflow limitation and airway inflammation
… chronic administration of maropitant citrate, a NK1 receptor antagonist, on clinical signs, airway hyperresponsiveness, and airway eosinophilia when given immediately following allergen challenge and in a chronic setting. To study efficacy in acute asthmatic crises, 7 cats received subcutaneous …
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The role of Substance P in chronic traumatic encephalopathy
… much to be discovered about the role of the SP/NK1 system and its potential involvement following rmTBI and these studies provide the groundwork for future developments in this area.