Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"NK cell receptors"”.
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The role of natural killer cells in control of varicella zoster virus infection
Varicella zoster virus (VZV) is a globally important virus with significant health and economic impacts. Although primary VZV infection is often perceived as a mild childhood illness, VZV infection is lifelong and reactivation of the latent virus in the elderly and immunocompromised population …
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Senescence and the Innate Immune System
Cellular senescence prevents deoxyribonucleic acid (DNA) damaged cells undergoing proliferation, protecting against malignancy but at the expense of senescent cell accumulation. Since the proportion of senescent hepatocytes in man correlates closely with liver injury, fibrosis stage and mortality, …
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The Role of Qa-2, the Functional Homolog of HLA-G, in a Mouse Model of Behcet's Disease Induced by HSV Inoculation
… HLA-G interacts with different natural killer (NK) cell receptors and is able to inhibit NK and T-cell cytotoxicity, as well as T-cell proliferation. An HLA-G 3741_3754 14-base pair insertion allele was significantly more frequent in Behcet's disease (BD), with ocular, arthritis, and CNS …
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Improving Nk Cell Therapy For Osteosarcoma
… 30 years. Adoptive transfer of Natural Killer (NK) cells holds promise for a new, non-toxic therapy for OS. NK cells are part of the innate immune system and readily kill metastatic and chemotherapy-resistant OS <em>in vitro</em> and in murine models. However, there is little data regarding …
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Transcriptional Regulation of Clr-b (Clec2d) in Health and Disease
… infectious disease and cancer. Natural killer (NK) cells are innate lymphocytes that recognize and eliminate pathological cells. Target cell recognition is facilitated by germline-encoded NK cell receptors, including the NKR-P1B inhibitory receptor. The NKR-P1B-ligand, Clr-b, is broadly …
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Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer
<p>NK cells are known to play an important role in the natural defense against viral infections and tumor immune surveillance. Through complex interactions between NK cell receptors and target cell ligands, transformed or unhealthy cells are identified and rapidly eliminated. NK cells have been …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… normal maturation and activation of B and T cells. Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody dependent cellular cytotoxicity (ADCC) of human NK cells. In this study, I show that Vav-1 is also expressed in murine NK cells. …
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IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells
… receptor (TLR) signaling. Both murine and human NK cells express high levels of IL-1R8 but its functional role in this cell type has not been described so far. Natural Killer (NK) cells are innate lymphoid-derived cells and are able to recognize damaged, stressed, viral infected or tumor cells, …
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Exploiting the Molecular Mechanisms of TAPBPR for use in Cancer Immunotherapy
… only high affinity peptides are presented at the cell surface to induce activation of CD8+ T cells. It has previously been shown that a recombinant soluble TAPBPR (sTAPBPR) molecule is capable of catalysing peptide exchange when applied to cells exogenously, with a further antibody-conjugated …
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T-Lymphozyten aus Nabelschnurblut tragen den Killer cell Lektin-like Receptor G1 (KLRG1) : eine phänotypische und funktionelle Charakterisierung
Anhand der Expression des "Killer cell Lectin-like Receptor G1" (KLRG1) konnte bei adulten Mäusen und Menschen eine einzigartige Subpopulation von T-Zellen beschrieben werden, die phänotypisch den Effektor- bzw. Gedächtniszellen zuzurechnen sind und ihre Teilungsfähigkeit verloren haben. …