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Showing 1 to 20 of 134 for “"NK cell"”.
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Improving Nk Cell Therapy For Osteosarcoma
… 30 years. Adoptive transfer of Natural Killer (NK) cells holds promise for a new, non-toxic therapy for OS. NK cells are part of the innate immune system and readily kill metastatic and chemotherapy-resistant OS <em>in vitro</em> and in murine models. However, there is little data regarding …
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Effect of bovine lactoferrin on T cell and NK cell populations and NK cell cytotoxicity in neonatal piglets
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Seth Robbins (srobbins@illinois.edu) on 2013-08-30T16:47:06Z Item is restricted until 2015-08-30T16:47:05Z
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Role of Stat3 In Human Nk Cell Functions
<p>Natural Killer (NK) cells are cytotoxic lymphocytes, which play a critical role in the immune response against malignant cells and microbial infections. NK cells are equipped with activating receptors, which upon detecting ligands expressed on stressed cells induce cytolytic activity of NK …
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NK cell determinants of immunity to mycobacterium tuberculosis in humans
Natural killer (NK) cells are highly equipped responders to pathogen-infected and neoplastic cells by directly killing target cells and secreting immunoregulatory cytokines. Our understanding of the role of NK cells in TB pathogenesis remains incomplete. This thesis aimed to investigate the …
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Importance of specific NK cell subsets for antitumor immunity in HPV+ cancers
… and the incidence of HPV+ head and neck squamous cell cancers is fast increasing worldwide. Survival rates for patients with locally advanced disease are poor and variable after standard of care (SOC) treatment. Identifying the antitumor host immune mediators important for treatment response and …
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Role of Siglec-7 in ganglioside recognition and modulating NK cell biology
… lectin-7 (Siglec-7), expressed primarily on NK cells,<br/> binds preferentially to alpha2,8 linked disialic acids such as present in the<br/> ganglioside GD3 that is upregulated in certain cancers. Siglec-7 is classified as<br/> an inhibitory receptor as it contains immunoreceptor tyrosine …
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The transcriptional programme of natural killer (NK) cell functional maturation and maintenance
Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in immune surveillance requires that NK cells are present within tissues in a quiescent state. The functional maturation of NK cells is a tightly regulated process which is controlled by …
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HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines
… antibodies (mAb) may depend on immune effector cells that express Fc receptors (FcR) for immunoglobulin G. Natural killer (NK) cells are innate immune effector cells that play a crucial role in cancer rejection and immunosurveillance. Importantly NK cells express the Fcgamma receptor IIIa …
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Targeting Unique Domains of Lsd1 Regulates Pediatric Glioma Innate Immunity and Nk Cell Metabolism
… of chromatin accessibility is a key mechanism of cellular identity, allowing different tissues to develop using the same DNA template. Cancers will often hijack these epigenetic pathways, reactivating developmental genes to drive growth and deactivating tumor suppressor and immune recognition …
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Kir-Based Inhibitory Cars Overcome Car-Nk Cell Trogocytosis-Mediated Fratricide and Tumor Escape
… surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted the transfer of the CAR-cognate-antigen from tumor to NK cells, resulting in (1) lower …
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NK Cell Function and Tumor Resistance in Mice Transgenic for Antibody to NK Inhibitory Receptors
… system monitors and eliminates transformed cells before their growth. Transformed cells that survive the immune response are escape variants selected by nature as they have developed mutations in immune recognition components. To boost immune response to these tumors, several types of …
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Effect of Entinostat On Nk Cell-Mediated Cytotoxicity Against Os Cells and Os Lung Metastsis
… the HDAC inhibitor entinostat on the efficacy of NK cell therapy for OS lung metastasis. The Lung is the most common site of OS metastatic spread in OS and pulmonary metastasis is the main cause of mortality. We have previously demonstrated that NK cell therapy has minimal efficacy against OS …
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Dynamic Assessment of Nk Cell Interactions With Pediatric Tumor Cells to Predict Response to Immunotherapy
<p>Due to Natural Killer (NK) cells’ capacity to target tumor cells without prior sensitization, adoptive NK cell therapy represents a promising immunotherapy approach for pediatric cancer patients. Our laboratory has developed an NK cell expansion protocol that generates large quantities of NK …
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Delineating the Role of CD244 in NK Cell Cytotoxicity and the Contribution of Ly108 to Thymocyte Development
… for a breach in tolerance of both T and B cells leading to the production of self reactive antibodies. Analysis of common strains of laboratory mice revealed the existence of two stable haplotypes (b and z) of the SLAM family gene cluster. Given recent studies identifying polymorphisms in …
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Oncolytic viruses enhance long-term NK cell anti-tumor cytotoxicity through AP-1 and IRF pathway activation
<p>Natural killer (NK) cell therapeutics have emerged as a promising strategy in adoptive cellular therapy. While genetic modifications of NK cells can enhance their antitumor activity, modulating the tumor to augment NK cell recognition and function remains underexplored. In this study, we …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… normal maturation and activation of B and T cells. Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody dependent cellular cytotoxicity (ADCC) of human NK cells. In this study, I show that Vav-1 is also expressed in murine NK cells. …
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Suppression of NK cell-mediated cytotoxicity and immunoenhancement of CD40 ligand against porcine reproductive and respiratory syndrome virus
… Arterivirus). PRRSV has a restricted host and cell tropism, with porcine alveolar macrophages (PAMs) as important host cells. In 2006, most swine farms in China experienced a “high fever disease of swine” caused by new PRRSV variants, which led to great economic losses to Chinese swine …
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Modulation of Clr-b Ligand for the Inhibitory NKR-P1B NK Cell Receptor in Response to Transformation and Genotoxic Stress
… disease and malignancies. Natural killer (NK) cells are large granular lymphocytes that are critical for the innate immune response. NK cells recognize target cells undergoing pathological alterations such as viral infection and transformation, through germline-encoded receptors. The …
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Exploring Veto Activity: DNAM-1-CD155 Axis in Overcoming NK Cell-Mediated Allo-Rejection and Applications for CAR-T Cell Therapy
… Miller et al. defined veto activity, it enables cells to target host cytotoxic T lymphocyte (CTL) precursors specific to veto cells' antigens, selectively eliminating anti- donor T cell clones without inducing rejection. By leveraging this unique immune property, two key research aims were …
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