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Showing 1 to 20 of 198 for “"NK Cells"”.
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Signal transduction events in human NK cells: role of PKC and calcium uptake in activated and inactivated NK cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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NK Cells and Their Role in Disease and Cancer Treatment
Natural killer (NK) cells are a crucial part of the human immune system. They play an important role in fighting and controlling viral infections as well as killing cells that have transformed into tumors. NK cells are involved in the pathogenesis of a number of diseases and in this thesis we will …
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The role of NK cells in selectin-dependent tumor suppression
… mice, and discovered that natural killer (NK) cell recruitment to tumors in Matrigel is impaired. NK cells in ELP-' and L'/ mice appear otherwise normal and functional. NK cells express L-selectin and selectin ligands, and are known to be tumoricidal. In mice depleted of NK cells, either …
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
NK cells are innate lymphocytes involved in the elimination of transformed, infected, stressed, antibody-coated and transplanted cells. The goal of this thesis, as well as the interest of our laboratory is to explore the MHC-independent “missing-self” branch of NK recognition, and more …
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Investigating the role of CD56⁻ ‘atypical’ NK cells in Gambian children with asymptomatic malaria
… remains poorly understood. Natural Killer (NK) cells are a diverse group of innate lymphoid cells with well-documented roles in early defense against infections. They exert cytotoxic effects on infected cells and can enhance immune clearance through antibody-dependent mechanisms. In malaria, …
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Activation State of Human T and NK Cells Increases Sensitivity to Death by Streptococcus pneumoniae
… Spn correlated with CD8 T cell, CD4 T cell, and NK cell survival. Looking further, we identified that lymphocytes incubated with Spn lysates in the presence of stimulation had increased susceptibility to death relative to non-stimulated cells. We concluded that activation may significantly …
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IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells
… receptor (TLR) signaling. Both murine and human NK cells express high levels of IL-1R8 but its functional role in this cell type has not been described so far. Natural Killer (NK) cells are innate lymphoid-derived cells and are able to recognize damaged, stressed, viral infected or tumor cells, …
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Combination Therapy With Aerosol Il-2 and Nk Cells For The Treatment of Osteosarcoma Lung Metastasis
… the efficacy of combining natural killer [NK] cell therapy with aerosol interleukin-2 [IL-2] for the treatment of osteosarcoma lung metastasis. The expression of NKG2D ligands was analyzed in five different human osteosarcoma cell lines and 103 patient samples (47 from primary tumors and 56 …
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Modulating Immunometabolism to Improve The Activity of Car-Nk Cells Targeting Cd70 In Renal Cell Carcinoma
… and the challenges of toxicity with CAR-T cells highlight the need to develop new cell therapy products that are at the same time effective and safe.</p> <p>We propose an innovative strategy using cord blood (CB)-derived natural killer (NK) cells engineered to target ccRCC as a safe and …
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Modeling of NK Cells in Pediatric Patients With Unusually Severe or Recurrent HSV Using High-Dimensional Flow Cytometry
… Our lab studies human Natural Killer (NK) cells, which are important in innate immune responses to viral infections and tumors. A publication in 2013 by Ornstein et al from our lab studied HSV+ pediatric patients and found some associations between severe infection and defects in NK …
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The Roles of miR-155 and miR-15/16 in Natural Killer Cell Function and Maturation
<p>Natural Killer (NK) cells are a crucial component of the immune system, with a role in both early host defense against pathogens and tumor immunosurveillance. NK cells develop in the bone marrow from a common lymphoid precursor, along with T and B cells, but undergo a separate education process. …
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The transcriptional programme of natural killer (NK) cell functional maturation and maintenance
Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in immune surveillance requires that NK cells are present within tissues in a quiescent state. The functional maturation of NK cells is a tightly regulated process which is controlled by …
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Ex Vivo Expanded Cord Blood Natural Killer Cells As A Novel Therapeutic For Multiple Myeloma
… date, is incurable. Allogeneic natural killer (NK) cells are active in various hematologic malignancies and may have a role against MM. Umbilical cord blood is a potential source for allogeneic NK cells and <em>ex vivo</em> expanded umbilical cord blood-derived NK (CB-NK) cells demonstrate …
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A License to Kill: Understanding Natural Killer Cell Licensing to Fight Cancer
<p>Natural killer (NK) cell education is an essential developmental process for NK cell effector function, that renders some NK cells “licensed” and others “unlicensed” (with heightened or lowered effector function potential, respectively) against tumor and targets lacking self-molecules. However, …
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Membrane Bound Il21 Promotes Natural Killer Cell Expansion Through Mir 124-3P Mediated Regulation
<p>Natural Killer (NK) cells are cells of the innate immune system that act as first line of defense against viral infections and participate in tumor immune surveillance. NK cells do not cause graft versus host disease (GvHD), or require prior antigen exposure to exert anti-tumor activity, hence …
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Role of Nlc Cells in Murine Models of T Cell-Dependent Responses
NK cells are part of the innate immune system, yet they can also modulate the acquired immune response. Activated NK cells, for instance, can increase antigen specific IgG2a production in response to T independent responses, mostly through IFN-gamma secretion. Previous experiments examining the …
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Bidirectional Natural Killer Cell and Dendritic Cell Interactions in HIV-1 Pathogenesis
Natural killer (NK) and dendritic cell (DC) interactions are pivotal for the development of immune responses, which lead to bidirectional NK:DC activation. In HIV-1 infection, both NK cell and DC function are impaired, resulting in dysfunctional NK:DC crosstalk. We demonstrate that NK:DC …
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NK cell determinants of immunity to mycobacterium tuberculosis in humans
Natural killer (NK) cells are highly equipped responders to pathogen-infected and neoplastic cells by directly killing target cells and secreting immunoregulatory cytokines. Our understanding of the role of NK cells in TB pathogenesis remains incomplete. This thesis aimed to investigate the …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… the specificity and function of natural killer: NK) cells, their differentiation has not been fully elucidated. Previous studies of thymocyte development <italic> in vitro</italic> indicate that double negative: CD4<super>&minus</super>CD8<super>&minus</super>, DN) thymocytes can develop into …
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Improving Nk Cell Therapy For Osteosarcoma
… 30 years. Adoptive transfer of Natural Killer (NK) cells holds promise for a new, non-toxic therapy for OS. NK cells are part of the innate immune system and readily kill metastatic and chemotherapy-resistant OS <em>in vitro</em> and in murine models. However, there is little data regarding …
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