Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 403 for “"NK"”.
-
Selbsttoleranz von NK-Zellen
In den letzten Jahren wurden im murinen Modell NK-Zellen detektiert, welche keinen bekannten HLA-spezifischen inhibitorischen Rezeptor exprimieren. Diese Entdeckungen widersprechen dem bisher gültigen at-least-one -Modell, nach dem die Selbsttoleranz durch mindestens einen inhibitorischen Rezeptor …
-
NK Cell Function and Tumor Resistance in Mice Transgenic for Antibody to NK Inhibitory Receptors
… the best efficacy in human clinical trials. NK cells, cytolytic effector cells of the innate immune system, are implicated in tumor surveillance. Inhibitory Ly49 receptors determine the specificity of murine NK cells by recognizing of MHC class I molecules expressed on the target cell. This …
-
Improving Nk Cell Therapy For Osteosarcoma
… 30 years. Adoptive transfer of Natural Killer (NK) cells holds promise for a new, non-toxic therapy for OS. NK cells are part of the innate immune system and readily kill metastatic and chemotherapy-resistant OS <em>in vitro</em> and in murine models. However, there is little data regarding …
-
The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… dependent cellular cytotoxicity (ADCC) of human NK cells. In this study, I show that Vav-1 is also expressed in murine NK cells. Vav-1-/- mice had normal numbers of splenic NK cells, and these displayed a similar expression profile of NK cell receptors as cells from wild type mice. Unexpectedly, …
-
Effect of bovine lactoferrin on T cell and NK cell populations and NK cell cytotoxicity in neonatal piglets
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Seth Robbins (srobbins@illinois.edu) on 2013-08-30T16:47:06Z Item is restricted until 2015-08-30T16:47:05Z
-
Signal transduction events in human NK cells: role of PKC and calcium uptake in activated and inactivated NK cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Role of Stat3 In Human Nk Cell Functions
<p>Natural Killer (NK) cells are cytotoxic lymphocytes, which play a critical role in the immune response against malignant cells and microbial infections. NK cells are equipped with activating receptors, which upon detecting ligands expressed on stressed cells induce cytolytic activity of NK …
-
Studies on the mechanism of human natural (NK) cell-mediated cytotoxicity (CMC): the role of lipoxygenation and arachidonic acid metabolites in NK-CMC
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
NK Cells and Their Role in Disease and Cancer Treatment
Natural killer (NK) cells are a crucial part of the human immune system. They play an important role in fighting and controlling viral infections as well as killing cells that have transformed into tumors. NK cells are involved in the pathogenesis of a number of diseases and in this thesis we will …
-
NK cell determinants of immunity to mycobacterium tuberculosis in humans
Natural killer (NK) cells are highly equipped responders to pathogen-infected and neoplastic cells by directly killing target cells and secreting immunoregulatory cytokines. Our understanding of the role of NK cells in TB pathogenesis remains incomplete. This thesis aimed to investigate the …
-
The role of NK cells in selectin-dependent tumor suppression
… mice, and discovered that natural killer (NK) cell recruitment to tumors in Matrigel is impaired. NK cells in ELP-' and L'/ mice appear otherwise normal and functional. NK cells express L-selectin and selectin ligands, and are known to be tumoricidal. In mice depleted of NK cells, either …
-
Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
NK cells are innate lymphocytes involved in the elimination of transformed, infected, stressed, antibody-coated and transplanted cells. The goal of this thesis, as well as the interest of our laboratory is to explore the MHC-independent “missing-self” branch of NK recognition, and more …
-
Importance of specific NK cell subsets for antitumor immunity in HPV+ cancers
… improving clinical outcome. The natural killer (NK) cells are a critical component for antitumor innate effector immunity. Among the multitude of activation and inhibitory receptors on immune cells, HLA-DR is recognized as an important activation marker on both CD8 T and NK cells. Literature …
-
Role of Siglec-7 in ganglioside recognition and modulating NK cell biology
… lectin-7 (Siglec-7), expressed primarily on NK cells,<br/> binds preferentially to alpha2,8 linked disialic acids such as present in the<br/> ganglioside GD3 that is upregulated in certain cancers. Siglec-7 is classified as<br/> an inhibitory receptor as it contains immunoreceptor tyrosine …
-
The transcriptional programme of natural killer (NK) cell functional maturation and maintenance
Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in immune surveillance requires that NK cells are present within tissues in a quiescent state. The functional maturation of NK cells is a tightly regulated process which is controlled by …
-
HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines
… (FcR) for immunoglobulin G. Natural killer (NK) cells are innate immune effector cells that play a crucial role in cancer rejection and immunosurveillance. Importantly NK cells express the Fcgamma receptor IIIa (FcgammaRIIIa) and various cytokine receptors, which can be activated upon …
-
Defining How Polymorphisms at the Slam Family Locus Affect NK and T Cell Function
… as systemic lupus erythematosus (SLE) and X-linked lymphoproliferative disease (XLP). The antinuclear autoantibody (ANA) causative locus, Sle1b, in the NZM2410 mouse model of lupus has been shown to contain the entire SLAM family (SF) locus. Whereas, XLP is caused by mutations in a critical …
-
Targeting Unique Domains of Lsd1 Regulates Pediatric Glioma Innate Immunity and Nk Cell Metabolism
… as a cancer target in pediatric glioma is unknown. LSD1 can be inhibited by small molecules with unique mechanisms of action, binding to either the catalytic site directly, or to an allosteric interface region. These LSD1 inhibitors produce differing effects in various cell types, dependent …
Page 1 of 21