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Showing 1 to 15 of 15 for “"NIPT"”.
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Obstetrician and Gynecologist Utilization of The Nipt Expanded Testing Option
<p>Noninvasive prenatal testing (NIPT) enables the detection of common fetal aneuploidies such as trisomy 21, trisomy 18, trisomy 13, and sex chromosome abnormalities via analysis of cell-free fetal DNA circulating in maternal serum. Although the accuracy of NIPT for fetal aneuploidy is expected to …
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Nipt Results Indicative of Maternal Neoplasms: Genetic Counselors' Preferences and Attitudes
<p>Performing non-invasive prenatal testing (NIPT) on a pregnant woman with a chromosomally abnormal neoplasm may incidentally lead to the diagnosis of cancer due to the coexistence of circulating tumor and placental DNA. Published information regarding NIPT’s accuracy for neoplasm screening is …
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Cell-free fetal DNA (cffDNA) enrichment for non-invasive prenatal testing (NIPT): a comparison of molecular techniques
… loss. Developing non-invasive prenatal testing (NIPT) is a key area of research and methods to increase the level of cell-free fetal DNA (cffDNA) within the maternal circulation have been discussed to improve accuracy of such tests. In this study, three strategies; co-amplification at lower …
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Patient Perception of Negative Non-Invasive Prenatal Testing Results
<p>Non-invasive prenatal testing (NIPT) uses cell-free fetal DNA to assess for fetal aneuploidy during pregnancy. NIPT has higher detection rates and positive predictive values than previous methods; however, NIPT is not diagnostic. Studies suggest patients may underestimate the limitations of …
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Genetic Counselors' Experiences With and Approaches to Discordant Genotypic and Phenotypic Sex Detected Via Non-Invasive Prenatal Testing
… via non-invasive prenatal testing (NIPT-DSI). Thus, it is imperative to investigate what GCs consider important when counseling about NIPT-DSI and assess how GCs perceive their role in such cases. Prenatal and pediatric GCs were surveyed regarding previous experiences of NIPT-DSI, …
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Anchoring and Uptake of Non-Invasive Prenatal Testing In The First and Second Trimester
<p>Non-invasive prenatal testing (NIPT) is a highly sensitive and specific screen for common aneuploidies that eliminates the risk of miscarriage that diagnostic tests carry. It is unclear how this new prenatal option will impact pregnant women’s decision making process. Women undergoing genetic …
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Current Genetic Counseling Practice Following Positive Non-Invasive Prenatal Testing For Sex Chromosome Abnormalities
… following a non-invasive prenatal testing (NIPT) result positive for a sex chromosome abnormality (SCA). The positive predictive value for SCA with NIPT is lower than seen for Trisomy 21 due to natural loss of the X chromosome from maternal cells during aging, confined placental mosaicism, …
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Attitudes to ward and Utilization of Non-Invasive Prenatal Testing For Chromosome Aneuploidy Among Ob/Gyns
… complications. Non-invasive prenatal testing (NIPT) for chromosome aneuploidy became commercially available in the fall of 2011, with detection rates similar to those of invasive procedures for the common autosomal aneuploidies (Palomaki et al., 2011; Ashoor et al. 2012; Bianchi et al. 2012). …
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Women’s decision making process regarding prenatal diagnostic testing
… emergence of a Noninvasive Prenatal Testing, NIPT, the primary goal of this study was to explore factors that influence women’s decision to have an invasive, a non-invasive or no further testing at all. Design and sample: The Prenatal Decision Making Questionnaire (PDMQ) developed for the …
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Patient Understanding of Fetal Sex Versus Gender in the Context of Routine Cell-Free DNA Screening
<p>Non-invasive prenatal testing (NIPT) is the current standard of care to screen for fetal aneuploidy using cell-free DNA (cfDNA). NIPT screens for sex chromosome aneuploidies (SCAs) and in doing so, can predict fetal chromosomal sex. Despite sex and gender being distinct concepts, many patients …
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Manipulation and Characterization of Morphology and Composition in Mono- and Heterometallic Nanoparticles
… branched morphologies of FePt, CoPt and NiPt with comparable compositions enabled the influence of elemental composition upon ORR activity within non-pseudospherical materials to be elucidated. In contrast to pseudospherical NPs, where prior art suggests a preference for NiPt bimetallic …
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Molecular Pathology: Potential Biomarkers For The Detection Of Down Syndrome Pregnancies
… as a possible non-invasive prenatal testing (NIPT) platform to assess its ability and efficiency to analyse cffDNA. Samples were spiked by trisomy genomic DNA for T21, T18 and T13 and were tested to mimic the low fraction of cffDNA in the maternal blood samples. The T21 multiplexing assay …
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Efficacy of Genetic Testing Methodologies for Prenatal Detection of Skeletal Anomalies and Craniosynostosis Syndromes
… detected via chromosome microarray. Single gene NIPT would have detected 60.4% of the skeletal dysplasia diagnoses. The suspected skeletal dysplasia diagnosis on ultrasonography was incorrect in 18.9% of our molecularly confirmed skeletal dysplasia cases, indicating the importance of ordering …
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Prenatal Screening Decision-Making Facilitated Through An Online Patient Education Module
<p>As recommendations for prenatal genetic screening are expanded to include patients with pregnancies at low risk for aneuploidy, there is a need to develop accessible mechanisms to promote informed decision-making about genetic screening. The use of patient decision aids has been shown to promote …
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Non-Invasive Prenatal Screening (Nips) Testing Motivations and Informed Decision Making In The Low-Risk Population
<p>Non-Invasive Prenatal Screening (NIPS) provides a risk assessment for aneuploidies by utilizing cell-free DNA (cfDNA). Recently, it was recommended that NIPS be offered to all pregnant people regardless of a priori risk for aneuploidy. In the absence of an increased risk, alternative motives for …