Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"NHR"”.
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Effects Of Simultaneous Exercise And Speech Tasks On The Perception Of
… frequency (F0), noise-to-harmonic ratio (NHR), jitter percent (jitt %), shimmer percent (shim %), and participants' self-perception of dyspnea. The results indicated that speech alone, whether it was with or without amplification, had no effect on the sensation of dyspnea. However, when …
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Carbenos Metala-N-heterocíclicos: aportaciones a un nuevo concepto en química organometálica
… diaminocarbeno de fórmula general fac-[Mn{C(NHR)(NHMe)}(CO)3(bipy)]+, [Fe(Cp)(CO)2{C(NHR)(NHMe)}]+ y [Fe(Cp)(CNR)(CO){C(NHR)(NHMe)}]+ y sus correspondientes derivados desprotonados formamidinilo, que en los complejos de Fe(II) forman metalaciclos por ataque nucleofílico intramolecular a un …
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The Role of the Ubiquitin-Proteasome System in the Regulation of Nuclear Hormone Receptor-Dependent Transcription
Nukleare Hormonrezeptoren (NHRs) sind Liganden-abhängige Transkriptionsfaktoren mit breitem physiologischem sowie pathophysiologischem Funktionsspektrum. Molekulare Therapien die sich gegen NHRs richten, stellen eine optimale Behandlung einiger humaner Krankheiten dar. Der Östrogenrezeptor ist …
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Light-activated gene expression
… This method uses the Nuclear Hormone Receptor (NHR) family as a model system. This tool provided an opportunity to study the spatial and temporal control of genes by using small synthetic molecules and light. In the late 1990s, we first demonstrated this concept by using as a photo-caged …
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Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… of the family of Nuclear Hormone Receptors (NHR). Previously, the Repa lab identified VDR as the fourth most abundant NHR in mouse islets based on mRNA levels, also, VDR is clearly present in human islets [1]. In the past years multiple epidemiological studies have implicated Vitamin D …
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LC - ¹³C NMR utilizing dynamic nuclear polarization (DNP) for signal enhancement
… is overcoming the relatively low sensitivity of NHR as a chromatographic detector. For the ¹H nuclide this is much less of a problem; the sensitivity ;s approximately 6000 times more sensitive than that of ¹³C nuclei. For this reason, much of the literature focuses on LC - ¹H NMR. To ever …
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Novel N-heterocyclic activations mediated by magnesium reagents having sterically hindered ligands
… isocyanates to yield the relevant ureas [(NHR)C(=O)(NPh2)] (R = tBu, 29, R = Cy, 39, R = Et, 43) in yields ranging from 99 to 100%. Similarly tris(amido) complex [NaMg(NPh2)3] 30 catalyses the trimerisation of aryl isocyanates under mild reaction conditions. The isolation of key …
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Regulation of C. elegans behavior and physiology by the hypoxia-response pathway
… identified the nuclear hormone receptor NHR-46. We propose that CYP-36A1 functions as a hormone biosynthetic enzyme for the ligand of this receptor, thus mediating gene expression changes that alter stress physiology and behavior. We also found site-of-action and genetic evidence for at …
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Compuestos luminiscentes cicloplatinados con propiedades multifuncionales
… de tipo carbeno acíclicos [Pt(C^N)Cl{C(NHXyl)(NHR)}] por adición nucleofílica de aminas primarias sobre el isocianuro coordinado en los precursores [Pt(C^N)Cl(CNXyl)]. Estos derivados representan los primeros ejemplos de complejos diaminocarbenos acíclicos cicloplatinados con propiedades …
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Effects of site specific phosphorylation on the structure and functions of the glucocorticoid receptor
… factors, like nuclear hormone receptors (NHRs), are capable of exerting transcriptional regulation in the nucleus in response to various intra- and extracellular signals. Transcription factors contain segments that are intrinsically disordered (ID) under native conditions. …
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Regulatory Architecture of Non-Apoptotic Cell Death Program in C. Elegans
… that the Tailless/Tlx nuclear hormone receptor NHR-67 acts in parallel to these regulators to promote linker cell death in addition to linker cell migration. Finally, I show that the Wnt pathways and all known linker cell death mediators require the heat shock factor HSF-1 for cell death. …
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Chemistry of rhenium(I) tricarbonyl complexes of biomedical relevance
… an></span>-Me<sub>2</sub>bipy)(HNC(CH<sub>3</sub>)NHR)]BF<sub>4 </sub>complexes, the <span class=SpellE>monodentate</span> <span class=SpellE>amidine</span> ligand adopts the <i style='mso-bidi-font-style:normal'>E</i>, <i style='mso-bidi-font-style:normal'>E</i><i …
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Carbonyl Catalysis: Hydrolysis of Organophosphorus Compounds and Application in Prebiotic Chemistry
… organophosphorus compounds containing P(=O)-NHR subunits. Gratifyingly, the reaction proved efficient with phosphinic amides and phosphoramidates. Moreover, chemoselectivity was also studied and selective hydrolysis of the P(=O)-N bonds in the presence of P(=O)-OR bonds could be accomplished. …
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Part I: Steroid Receptor CO-Activator 3 (SRC-3) Expression in Lung Cancer and its Role in Regulating Cancer Cell Survival and Proliferation; Part II: Development of Phosphospecific Peptoid Ligand
… acetyltransferase and nuclear hormone receptor (NHR) coactivator, located on 20q12, which is amplified in several epithelial cancers and well studied in breast cancer, however, its role in lung tumorigenesis is unknown. We found that SRC-3 is over-expressed in 27% of the NSCLC patients, and SRC-3 …
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Metal Complexes of Functionalised Phenanthroline-based Ligands and Their Application Towards the Transformation of CO₂
… produced herein were designed with pendant –NHR groups which could assist in the activation of the CO<sub>2</sub> or molecular hydrogen (H<sub>2</sub>). No evidence was observed to confirm the reaction pathway, however there was a marked (11x) reduction in activity when the –NHPh moiety was …
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Derivatization of porphyrins for DNA and metal ion binding, especially by employing secondary sulfonamide links
… of the porphyrin by a secondary (SO<sub>2</sub>NHR) or tertiary (SO<sub>2</sub>NR<sub>2</sub>) sulfonamide group. The sulfonamide group was found to be a versatile way of expanding the porphyrin. The presence of a tertiary sulfonamide group instead of a dissociable proton improved the solubility …
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The Chemistry of Cycloaurated Complexes
… 2-pyridine thiocarboxamide ligands 2-(C₅H₅N)C(S)NHR (R= p-tolyl, CH₂Ph, Me, p-C₆H₅OMe) also underwent direct cycloauration upon reaction with H[AuCl₄]. Coordination via the pyridyl nitrogen and sulfur atom was confirmed by an X-ray crystal structure of cycloaurated 2-(C₅H₅N)C(S)NHCH₂Ph. The N,S …
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Genetic basis of inherited kidney and related tumours
… homologous (DS HR) and nonhomologous repair (DS NHR) pathways. Candidate novel RCC genes were sought by familial studies on 13 trios recruited to the 100KGP and the Human Molecular Pathology of Genetic Disease (HumGenDis) study with WGS/WES data available. Trio analysis identified a novel *de* …
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The role of orphan nuclear receptor DAX-1 (NR0B1) in human breast cancer cells: expression, proliferation and metastasis
<p>The orphan nuclear hormone receptor DAX-1 (Dosage Sensitive Sex Reversal, Adrenal Hypoplasia Congenita on the X Chromosome, gene 1) plays an important role in the development of adrenal and gonadal tissues and functions as a global negative-regulator of steroidogenesis. In addition, it is known …
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The Role and Immunogenicity of CBFA2T3-GLIS2 in Pediatric Acute Megakaryoblastic Leukemia
… 16 joins the three nervy homology regions (NHR) of CBFA2T3 to the five zinc fingers of GLIS2. This configuration enables the encoded chimeric transcription factor to bind GLIS consensus sequences throughout the genome and recruit transcriptional activators and repressors to alter gene …