Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"NHERF1"”.
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Nherf1 – New Modifier of Colorectal Cancer Progression
… molecular players involved are not well known. NHERF1 (Na+/H+ Exchanger Regulatory Factor 1) is an adaptor protein with apical membrane localization in polarized epithelia. In this study, we tested our hypothesis that NHERF1 plays a role in CRC. We examined surgical CRC resection specimens for …
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Structural Basis Of Epigenetic Regulation And Protein Scaffolding In Development And Diseases
… structural and functional studies of SMYD2 and NHERF1 and have determined their mechanisms of action in epigenetic regulation and protein scaffolding, respectively. </p> <p>Primarily identified as a histone lysine methyltransferase, SMYD2 has been shown to be play important roles in muscle …
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Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth
… protein Na(+)/H(+) exchange regulatory factor 1 (NHERF1) into a macromolecular signaling complex both in vitro and in pancreatic cancer cells. We also observe that disrupting the CXCR2 complex, by gene delivery or peptide delivery of exogenous CXCR2 C-tail, significantly inhibits the biologic …
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Testing Whether MRP4 (a cAMP Efflux Pump) and the Beta 2 Andrenergic Receptor (an Upstream Regulator of cAMP Signaling Pathways
… through which it binds to scaffolding proteins NHERF1 and PDZK1. Previous studies have shown that PDZK1 serves as a scaffold physically coupling MRP4 with the cystic fibrosis transmembrane conductance regulator (CFTR). This protein complex functionally couples cAMP regulation of CFTR function …
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
… of low-risk and high-risk E6 proteins, E6AP and NHERF1, on the key components of epithelial homeostasis: cell density, proliferation, commitment to differentiation and basal layer delamination. Importantly, we demonstrate that deletion of E6AP in keratinocytes delayed the onset of differentiation …
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A Critical Role Of Cxcr2 Pdz Motif-Mediated Interactions In Endothelial Progenitor Cell Homing And Angiogenesis
… Moreover, biochemistry study suggested that NHERF1, a PDZ domain containing scaffolding protein, preferred to interact with CXCR2 and its downstream effector, PLC-β3 in EPCs. Taken together, the data has demonstrated the role of CXCR2 PDZ motif-mediated macromolecular complex in EPC homing …