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Showing 1 to 6 of 6 for “"NHE1"”.
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ROLE OF ACID SPHINGOMYELINASE IN ICAM-1/NHE1-DEPENDENT ENDOCYTOSIS: IMPLICATIONS IN LEUKOCYTE TRANSMIGRATION
… pathway involving Na+/H+ exchanger 1 (NHE1). ICAM-1 itself plays a key role in transendothelial migration (TEM) of leukocytes, particularly via the transcellular route. This involves endothelial endocytic vesicles that coalesce into transmigration pores, through which leukocytes …
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Regulation Of Apoptotic Alkalinization Through Phosphorylation Of Sodium Hydrogen Exchanger Via P38 Mitogen Activated Protein Kinase
… membrane protein, sodium hydrogen exchanger-1 (NHE1), whose activity is regulated by the stress kinase p38 MAPK. In previous studies, upon cytokine withdrawal from cytokine-dependent lymphocytes induced the activity of the p38 MAP kinase which then phosphorylated the C-terminus of NHE1. To …
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Redox Regulation of Akt Phosphorylation in PTEN-/- Mouse Embryonic Fibroblasts
… phosphorylation by O2.-, we have also reported NHE1 as a regulator of Akt phosphorylation at the membrane. We showed for the first time that NHE1 interacts directly with Akt. This interaction allows NHE1 to serve as an additional anchor point for Akt recruitment to the membrane. Moreover, …
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Intracellular pH, the Proximate Signal for Cell Volume Changes that are Mediated by the Actin Cytoskeleton
… as a result of a change in pHi activates NHE1 to restore TRC pHi and volume.
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Transfektion migrierender Nierenepithelzellen mit dem Kalium-Kanal ROMK2
… (MDCK-F-Zellen) zu fin- den sind (z. B.: NHE1, Cl/HCO -Austauscher AE2). Diese reichern sich am Vor- derende der MDCK-F-Zellen an. Es war nicht bekannt, wo sich Markerproteine der apikalen Membran wiederfinden. Um dieser Frage nachzugehen, transfizierte ich MDCK-F-Zellen stabil mit dem …
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Die pH-Regulation isoliert in vitro perfundierter Kolonkrypten der Ratte
… basolateralen Transporter wurden als die Isoform NHE1 der Na+/H+-Austauscherfamilie (IC50 für EIPA bzw. HOE694 0,2 bzw. 2 µmol/l) und als DIDS-hemmbarer und Na+-abhängiger HCO3--Import charakterisiert. Experimente mit veränderten Triebkräften für Cl- wiesen darauf hin, daß es sich bei diesem …