Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"NGS analysis"”.
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Cancer risk prediction with next generation sequencing data using machine learning
… biology for next generation sequencing (NGS) analysis is rapidly increasing in genomics research. However, the effectiveness of NGS data to predict disease abundance is yet unclear. This research investigates the problem in the whole exome NGS data of the chronic lymphocytic leukemia …
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Characterisation of genetic complexity in chronic lymphocytic leukaemia
… CLL using targeted next generation sequencing (NGS) and high resolution single nucleotide polymorphism (SNP) array. NGS analysis of the immunoglobulin variable heavy-chain (IgHV) in 497 pre-treatment CLL patients found IgHV subclones in 18.5%, far higher than previously reported. SNP array …
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Mining the Genetic Diversity of the Pathogenic Protozoan, Neospora caninum
… burgeoning next generation sequencing (NGS) technologies and 𝘪𝘯-𝘴𝘪𝘭𝘪𝘤𝘰 tools have provided new opportunities to perform genome-wide scans in such organisms. Hence the objective of this body of work was to compare the genomes and transcriptomes of two distinct 𝘕. 𝘤𝘢𝘯𝘪𝘯𝘶𝘮 isolates, using …
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Defining the Transcriptional and Epigenetic Signature of Mouse Embryonic Stem Cells with Compromised Developmental Potency
… in a phenotypic screen using phage display. NGS analysis of the phage outputs indicates that there may be additional differences in cell surface markers between the control and compromised ES cell clones, but their specific details remain to be identified. Overall, we have identified the …
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Computer modelling of metabolic adaptions during mitochondrial dysfunction and machine learning to predict novel mitochondrial disease genes
… probabilities are currently used in an NGS analysis pipeline at the MRC Mitochondrial Biology Unit for diagnosing mitochondrial disease patient samples.
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Λειτουργική και γονιδιωματική ανάλυση της επίδρασης αναλόγων του ρετινοϊκού οξέος σε ανθρώπινα κερατινοκύτταρα
… επόμενης γενιάς (next generation sequencing, NGS). Η σύνθεση της RASP έγινε στοχεύοντας στη βελτίωση του θεραπευτικού δείκτη, του βιολογικού προφίλ και της επιλεκτικότητας ήδη υπαρχόντων συνθετικών ρετινοειδών, μειώνοντας έτσι τις παρενέργειες και βελτιώνοντας την κλινική τους …