Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 263 for “"NGS"”.
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Next-generation sequencing (NGS) for human disease research
차세대 염기 서열 분석법(Next-generation sequencing)은 DNA 유전 정보를 읽어내는 기술을 자동화한 1세대 생어(Sanger) 방식에서 대량의 병렬 데이터 생산이 가능하게 진화한 차세대 염기 서열 분석기가 생산한 데이터를 분석하는 기법을 의미한다. 2007년, 차세대 염기 서열 분석법의 등장은 무어의 법칙(Moore's law)을 능가하는 속도로 염기 서열 분석 비용을 감속시키고 있으며 곧 한 사람의 염기 서열 분석이 $1,000에 가능하게 되리라는 것이 명확해졌다. 차세대 염기 서열 분석법은 정착 단계를 …
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A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels
… fusions. Standard next-generation sequencing (NGS) methods cannot accurately detect genetic alterations at low frequencies because of inherent technical errors and the need for high sequencing depth. Blocker Displacement Amplification (BDA) technology enables selective detection of such rare …
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Design and characterization of novel immunogens for AIDS vaccine development and evaluation of a sample inference method for NGS Illumina amplicon data
… induce bnAbs targeted to MEPR or CD4bs. Our findings indicate that 1) neighboring domains influence the immunogenicity of gp41 MPER, and 2) priming with a small gp41 or gp120 immunogen, then subsequently boosting with larger and more native immunogens, may have the potential to elicit antibodies …
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DESIGNING BIOMIMETIC NANOPARTICLES TO TACKLE INTRACELLULAR PATHOGENS
… nanocarrier platform termed Nanoghosts (NGs), derived from the plasma membranes of human monocytes (THP-1 cells and primary CD14+ monocytes). These NGs were designed to retain key membrane features while excluding nuclear and cytoplasmic content, with the goal of targeting intracellular …
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Clinical Impact of A Highly Sensitive Next-Generation Sequencing Measurable Residual Disease Assay In Patients With Acute Lymphoblastic Leukemia
… a highly sensitive next-generation sequencing (NGS) MRD assay in 74 adults with ALL undergoing frontline therapy. Among remission samples that were MRD negative by multiparameter flow cytometry (MFC), 46% were MRD positive by the NGS assay. At the time of complete remission (CR), MRD negativity …
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Time-Resolved Studies of Magnetic and Non-Magnetic Narrow-Gap Semiconductors
… and engineering of narrow gap semiconductors (NGS). NGS based heterostructures are particularly interesting for spintronic applications due to their large spin-orbit coupling, which leads to considerable zero-field spin splitting. NGS are also candidates for electronic applications, such as …
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A novel genomics and bioinformatics approach to assess immunoglobulin and T cell receptor rearrangements and somatic hypermutation in lymphoproliferative disorders
… (SSeq). However, next generation sequencing (NGS) presents a promising alternative as it also allows high sample throughput and investigation of structural variation (SV) and mutation analysis.<br/><br/>Several NGS applications have been proposed for clonality and SHM status reporting but …
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Targeted next generation sequencing to improve solid tumour diagnosis using tissue-derived and cell-free DNA
Next generation sequencing (NGS) allows for high throughput sequencing of DNA and is commonly utilised in oncology research. Whilst whole genome and exome sequencing have been used to identify novel mutations in cancer patients, a more rapid and cost-efficient technology is required for clinical …
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Error Correction in Next Generation DNA Sequencing Data
… High throughput Next Generation Sequencing (NGS) technologies can sequence the genome of a species quickly and cheaply. Errors that are introduced by NGS technologies limit the full potential of the applications that rely on their data. Current techniques used to correct these errors are not …
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Development of Novel Methods to Minimize The Impact of Sequencing Errors In The Next-Generation Sequencing Data Analysis
<p>Next-generation sequencing (NGS) technology has become a prominent tool in biological and biomedical research. However, NGS data analysis, such as <em>de novo</em> assembly, mapping and variants detection is far from maturity, and the high sequencing error-rate is one of the major problems. …
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Diagnosi molecolare della Distrofia Muscolare di Duchenne e della Neurofibromatosi tipo 1 con la tecnologia di sequenziamento Next Generation
… "hot spots". Next Generation Sequencing (NGS) technology is useful for molecular diagnosis of diseases where laborious sequencing efforts are required. The aim of this study was to work out a method to use the high-‐throughput NGS technology in a diagnostic settings for Duchenne/Becker …
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Considerations for implementing a microcomputer database for Virginia control survey data
… the federal level. The National Geodetic Survey (NGS) publishes only the results of those surveys that their agency performs, as well as other surveys that meet certain criteria.Currently, geodetic control data are generally available only au: the federal level. The National Geodetic Survey (NGS) …
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Synthesis of contorted nanographenes via multi-fold alkyne benzannulation reactions
Nanographenes (NGs) of unique shape, size and properties are always at the center of attraction because of their potential application as semiconducting materials in organo-electronic devices. Contorted NGs have gained increased attention because of their fascinating molecular packing, reduced π-π …
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Computational methods for the analysis of next generation sequencing data
Recently, next generation sequencing (NGS) technology has emerged as a powerful approach and dramatically transformed biomedical research in an unprecedented scale. NGS is expected to replace the traditional hybridization-based microarray technology because of its affordable cost and high digital …
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Computational Pipeline for Human Transcriptome Quantification Using RNA-seq Data
… reads to a reference genome is a key step in NGS data analysis. Although storing alignment information in the Sequence Alignment/Map (SAM) or Binary SAM (BAM) format is now standard, biomedical researchers still have difficulty accessing useful information. In order to assist biomedical …
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Cancer risk prediction with next generation sequencing data using machine learning
… biology for next generation sequencing (NGS) analysis is rapidly increasing in genomics research. However, the effectiveness of NGS data to predict disease abundance is yet unclear. This research investigates the problem in the whole exome NGS data of the chronic lymphocytic leukemia …
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Clinical Utility and Impact of Targeted Nucleic Acid Sequencing in Myeloid Malignancies and Precursor Lesions
… necessary. Targeted next-generation sequencing (NGS) panels offer promise in detecting these molecular features. Furthermore, several myeloid precursor lesions, such as clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenias of undetermined significance (CCUS), have been …
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