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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"NG2"”.
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NG2/CSPG4 Regulates Alveolar Bone and PDL Microstructure in a Sex-Dependent Manner
… alveolar bone levels (Komori et. al, 2022). NG2/CSPG4, a type I transmembrane proteoglycan that binds to type VI collagen, is expressed in mineralizing tissues such as growth plate cartilage and cranial sutures. However, its role in regulating alveolar bone density and organization remains …
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A multi-isotopic geochemical investigation of the Lower Zone, Bushveld Complex, South Africa: implications for a crustal component for parental magmas
… Samples come from the Nooitgedacht Borehole 2 (NG2) at Union Section of the western limb of the Bushveld Complex, which sampled the Lower Zone. The 87Sr/86Sri (0.7043 – 0.7086) and Ndi values (-7.40 - -4.97) calculated in this study are in agreement with published data for the Bushveld. The …
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Optimization of a pericyte therapy to improve muscle recovery following hindlimb immobilization
… markers, such as neural/glial antigen 2 (Cspg4/NG2), melanoma cell adhesion molecule (Mcam/CD146), and platelet-derived growth factor receptor β (PDGFRβ). Currently, none of these markers are uniquely expressed by pericytes; therefore, cell heterogeneity likely exists when isolating based on one …
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The impact of diet-induced obesity and exercise on adipose-resident stem cells
… cell surface marker, neural/glial antigen 2 (NG2), including two pericyte subtypes based on Nestin expression (+/-). Male and female NG2-DsRed x Nestin-GFP reporter mice were placed on control or HFD for 6 wk prior to and following initiation of a 12 wk treadmill exercise program. NG2+Nestin- …
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Lithium and brain plasticity - studies on glial cell changes and electroconvulsive treatment-induced amnesia in rats
… have previously shown increased neurogenesis and NG2 cell proliferation in a rat model of ECT, electroconvulsive seizures (ECS). NG2 cells can differentiate into mature myelinating oligodendrocytes in the adult brain. Moreover, given the fact they are an abundant proliferative cell type in all …
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PERICYTE SUBTYPES AT THE INTERSECTION BETWEEN TISSUE REGENERATION AND PATHOLOGY
… based on molecular markers, Nestin-GFP-/NG2-DsRed+/ PDGFRâ+ (type-1) and Nestin-GFP+/NG2-DsRed+/ PDGFRâ+ (type-2). This thesis characterizes heretofore their unknown specific roles. Only type-2 pericytes have the potential, under optimized culture conditions, to generate neural cells. …
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Development of a pericyte-based strategy to recover aged skeletal muscle after disuse
… that muscle-resident perivascular stem cells (NG2+ and CD146+ pericytes), also considered the primary mesenchymal stem cell (MSC) in muscle, can effectively recover muscle mass in young adult mice following a period of immobilization. However, several questions remained after the completion of …
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Skeletal muscle pericyte response to acute and chronic electrical stimulation
… by multiplex flow cytometry in all samples. NG2+CD45-CD31- and CD146+CD45-CD31- pericytes were isolated following the acute study and gene expression was evaluated using high throughput qPCR. RESULTS: Acute electrical stimulation resulted in a non-significant trend for an increase in total …
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The Effect of Ischemia and High-Fat Diet on Pericyte Fate
… used mice with fluorescently labelled pericytes (Ng2/DsRed) that were fed normal or HF diet and then underwent unilateral femoral artery ligation surgery to induce ischemia. My data showed that ischemia increased pericyte number through proliferation. Pericyte phenotype and morphology changed with …
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Regulation of Oligodendrogenesis in a Rat Contusive Spinal Cord Injury
… 2 weeks after SCI. The number of proliferating NG2+ glial progenitor cells (NG2+/BrdU+) was also increased. Furthermore, the VEGF delivery increased the number of early proliferating cells that differentiated into mature oligodendrocytes, but not astrocytes, at 6 weeks after SCI. F3.VEGF …
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Stromal Derived Growth Factor Alpha (Sdf-1Α) Induces The Differentiation of Bone Marrow Progenitor Cells (Bmcs) Into Pericytes By Regulating Platelet Derived Growth Factor B (Pdgf-B) Transcription
… PDGFR-β<sup>+</sup> BMCs differentiated into NG2 and desmin positive pericytes <em>in vitro</em>. In contrast, inhibiting SDF-1α and PDGF-B abolished this differentiation process. <em>In vivo</em>, we injected TC71 or A4573 tumor-bearing mice with the SDF-1α antagonist, AMD3100 and found that …
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The role of complex gangliosides in glial cell biology
… T -/- mice had significantly lower numbers of NG2 positive early oligodendrocyte progenitors compared to wild-type and Sia T -/- mice, suggesting that complex gangliosides may affect early progenitor differentiation, proliferation or survival.
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Restoring bladder function by promoting neuronal regeneration
… post-injury increase in the CSPGs neurocan or NG2 in the DREZ. However, there was a delay in the post injury increase in phosphacan in the DREZ in the artemin treatment group. There was a rightward shift in the expression profile of phosphacan in the DREZ as a result of artemin treatment. This …
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The Role of Transcription Factors in Regulating Adult Neurogenesis after Excitotoxic Brain Injury
… cells (OPCs). Multipolar cells also expressed NG2, indicating OPCs were recruited into the lesioned striatum. Proneural genes can repress Olig2 lineage cells, and substantially increase neurogenesis when overexpressed in the adult brain. Proneural Dlx2-GFP and Pax6-GFP retroviruses were …
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Investigating the integrity of the vasculature and structural relationships of pericytes, astrocytes and the endothelial glycocalyx in an ex vivo hyperglycaemic rat retinal model
… syndecan-1 with anti-neuron-glial 2 antigen (NG2), anti-glial fibrillary acidic protein (GFAP), and anti-syndecan-1 antibodies respectively. Retinal blood vessels were detected with FITC-conjugated lycopersicon esculentum (Tomato) lectin. Fluorescent signals were detected using confocal …
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An investigation of the molecular structure, composition and biophysical properties of gum Arabic
… at two specific ecolocations in Nigeria (NG1 and NG2), have been investigated together with two previously characterised gum samples harvested from A. senegal and A. seyal originating from Sudan. The monosaccharide sugar composition analyses have shown that the A. seyal gum had a lower rhamnose …
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Development of a stem cell-based therapy for the recovery of skeletal muscle mass following immobilization
… following 14 days of remobilization post-disuse. NG2+CD31-CD45- and CD146+CD31-CD45- pericytes were collected using fluorescence-activated cell sorting (FACS) following the remobilization period, and gene expression was analyzed as a readout of functionality. Finally, both pericyte populations …
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A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
… expression for mural markers PDGFR-β, α-SMA, NG2 and supported hCB-EPC by day 14 of coculture with total tubule lengths near 12 mm/mm2. hCB-EPCs cocultured with MSCs underwent cell loss by day 10 with a 4-fold reduction in CD31/PECAM+ cells, in comparison to controls of hCB-EPCs in SMC …
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Stem cell transplantation in mouse models for Huntington's disease
… but also the oligodendroglial precursor marker NG2. This also points to the influence of the host tissue environment on graft physiology. As a cooperation project with the research group of Prof. Melitta Schachner, we also investigated genetically manipulated embryonic NSCs after transplantation …
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Therapeutic Aerobic Exercise in a Mouse Model of Breast Cancer: Effects on Tumor Progression, Angiogenesis, and Response to Chemotherapy
… and vessel maturity (colocalization of CD31 with NG2 and desmin). Hypoxia (EF5) was significantly reduced in the exercising animals, and MRI showed that tumors were more uniformly perfused in the running groups. Furthermore, exercise significantly enhanced the effectiveness of cyclophosphamide in …
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