Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"NFkB pathway"”.
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Alterations in endometrial immune cell populations affect endometrial cell functions
… could mediate this effect. The inflammatory NFkB pathway is the hallmark of IL-17 activity, but our results showed that in our uterine cell lines, IL-17 did not induce the NFkB pathway. Instead IL-17 activated an alternate MAPK signal transduction pathway, but only in the endometriotic 12Z …
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Cluster Determinant 44 (CD44) Receptor and Gout: Mechanistic Role in Pathogenesis and Therapeutic Targets
… target in gout, both through inhibition of NFkB pathway activation and modulation of macrophage phagocytosis of MSU crystals and in facilitating the uptake of small molecules that have an intracellular target in macrophages.</p>
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The influence of ECM on mesenchymal stromal/stem cell activity and their interactions with monocytes/macrophages
… over time. Three molecular mechanisms, the TNFα/NFkB pathway, TNFα/JNK/AP1 pathway, and the potential involvement of ROCK, were identified as specific effectors of MSC immunomodulatory activity within these environments. Further investigations into the crosstalk between MSCs and monocytes in …
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THE EFFECT OF FLAXSEED AND ITS LIGNAN COMPONENT ON ESTROGEN SIGNALING AND METABOLISM IN NORMAL AND CANCEROUS HEN OVARIES
… IRS1 that are a part of the IGF signaling pathway and are also implicated in a significant number of malignancies. Whole flaxseed diet also decreased the expression of the anti-apoptotic protein, BCL2L1 possibly by reducing the activation of the NFkB pathway. Ovarian tumors from 4 year old …
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Effect of HIV infection and pregnancy on parameters of vaginal immunity
… in HIV sexual transmission. We focused on two pathways: The NF-KB inflammation pathway that has been implicated in susceptibility to HIV infection, and two interferon pathways that have been associated with antiviral immune defense. We hypothesized that pregnant women have increased …
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CHARACTERIZATION OF THE EPIGENOMIC PROFILE SHAPING HUMAN FOXP3+ REGULATORY T CELL IDENTITY IN THE TUMOR MICROENVIRONMENT
… adaptation, with factors from non-canonical NFkB pathway among the top drivers. Overall, comprehensive understanding and dissection of multilayer epigenomic regulation can inform on novel targets for specific modulation of Tregs in the TME, with potential clinical relevance for the design of …
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ETHNOBOTANICAL SURVEY IN VALMALENCO (SONDRIO, ITALY): STUDY AND ENHANCEMENT OF THE PLANT AND CULTURAL BIODIVERSITY
… were then evaluated for their antioxidant (NRF2 pathway activation) and anti-inflammatory (NFKB pathway inhibition) potential by in vitro cell-based models, using two different cell lines (HEK293, R3/1). The experimental phase on the target species ended with the investigation on the …