Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"NFIL3"”.
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Regulation of Adaptive and Innate Immunity by the Circadian Transcription Factor NFIL3
… I show that the circadian transcription factor NFIL3 is critical for both adaptive and innate immunity by regulating TH17 cells and innate lymphoid cells (ILCs), respectively. First, NFIL3 transcriptionally represses RORgt, the master regulator of TH17 cells, by directly binding to the Rorgt …
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The role of JAK1 and JAK3 in CD8<sup>+</sup> effector T cells
… in CTL, including the transcription factor NFIL3. NFIL3 was shown to be upregulated in CD8<sup>+</sup> T lymphocytes following stimulation with IL-2 and regulated perforin and CD62L expression, suggesting a role in the regulation of CTL effector function.<br/>
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Identifying regulators of natural killer cell development through CRISPR screening of common lymphoid progenitors
… regulators of NK cell development such as *Nfil3*, *Runx3* and *Eomes*. Additional putative regulators, such as *Tcf3* (encoding E2A), *Rere*, *Bach1* and *Zfp652* were identified and validated using arrayed CRISPR screens. Due to the known role of *Tcf3*/E2A in the decision between the …
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Identifying regulators of cytotoxic T cell function through molecular and genetic screening
… highlighted the importance of HIF-1$\alpha$ and NFIL3 in CTL killing. The second half of the thesis focuses on primary human CTL. The combined degranulation and killing assay was further validated using patient-derived CTL, indicating its potential as a diagnostic test. I showed that the assay is …
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Selective HDAC6 Inhibition in Systemic Lupus Erythematosus
… analysis unveiled six genes (Cebpb, Ccr9, Spib, Nfil3, Lgals1, and Pou2af1) that may play a role in the aforementioned abnormalities. Overall, these findings show that HDAC6i decreased disease in NZB/W mice by targeting multiple components of the immune response, including glomerular cells, T …
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INSIGHT ON ANGPTL3 IMPACT ON HEPATIC METABOLISM AND FUNCTION
… of metabolic stress pathways (cAMP, PPARα, FOXO, NFIL3) leading to biomolecular adaptations reflected in spatially altered gene expression. These changes involved hepatic and extrahepatic signalling pathways, including thyroid hormones signalling, autophagy and bile acids metabolism. …