Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"NFIB"”.
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Characterizing The Recognition Motif and Novel Substrates of Carm1
… and identified that Nuclear Factor I-B (NFIB) is a major CARM1 substrate. <em>Nfib</em> and <em>Carm1</em> knockout mice die perinatally due to almost identical hyper-proliferation defects during lung development, suggesting a genetic link between NFIB and CARM1. NFIB can both activate …
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Coordinating Stem Cell Behavior in the Hair Follicle
… upregulated in the HFSCs is nuclear factor I/B (Nfib). Embryonic ablation of Nfib revealed that Nfib is required for the hair follicle morphogenesis and hair folliclemediated re-epithelization during wound repair. Meanwhile, to address the function of Nfib in established HFSCs, I conditionally …
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Investigating the initiation and progression of small cell lung cancer
… transcription factor Nuclear Factor I/B (Nfib in mouse, NFIB in human), which frequently occurred coincident with amplification of a previously characterized oncogene, L-myc (Mycl). Functional studies revealed cooperation between Nfib and Lmyc in cellular transformation. Comparative …
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Characterisation of a conserved motif found within the Dlx cis-regulatory element URE2 and its effect on mouse URE2-lacZ activity in transgenic mice
… namely the Nuclear- Factor-1 proteins: NFIA, NFIB, NFIC and NFIX. These genes are associated with transcriptional regulation, being repressors and/or activators of gene expression in the brain. We showed that NFIC was able to utilize the mURE2nt699-719 sequence to reduce the luciferase …
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The Use of Catalytically Dead Cas9 to Identify Key Transcription Regulators in Triple Negative Breast Cancer
… focused on transcription regulators like FOXC1, NFIB and NFE2L3. We then performed RIME proteomics to identify which proteins are in close proximity to dCas9 and thus potentially bound to these putative regulatory regions. In addition, we developed a novel, statistical approach to analyse these …
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Home Sweet Home: Epigenetic Paths of Stem Cells In and Out of Their Niche
… genes. I found that NFI transcription factors (NFIB and NFIX) act redundantly in mouse skin to maintain the undifferentiated state of progenitors in hair follicles, sebaceous glands and sweat glands. Combining gene expression and chromatin profiling, I discovered that NOTCH signaling, known to …
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The Role of Annexin A6 in Osteoporosis
… of 7 genes, Anxa6, Col5a1, Col6a2, Eno1, Myof, Nfib and Scara5, were significantly altered in the in vitro and in vivo osteoporosis models. Lastly, to determine whether the genetic variations of these 7 genes were associated with bone density and osteoporosis phenotypes in humans, we performed …
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Signal Transduction in Skeletal Muscle Mediating Responses to Phenotype Altering Signals
… the anabolic deficits were — 4-fold increases in NFiB protein, the inflammation-associated transcription factor, as well as —50 % and —20 % decreases in protein expression of p70 S6K of healthy elderly and elderly with type II DM, respectively. These results suggest that the elderly are unable to …