Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"NFI"”.
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Analysis of NFI-X3 and STAT3 Interaction and Its Functions
… is regulated by two transcription factors, NFI-X3 and STAT3, which form a complex with each other (Singh et al., 2011). Here, we show that the N-terminal domain of NFI-X3 is sufficient and required for its interaction with STAT3. We also show that the DNA-binding domain of NFI-X3 is required …
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STRUCTURAL ANALYSES OF TRANSCRIPTION FACTOR/DNA COMPLEXES: NFI-X AND NF-Y
… the present PhD project focuses on two TFs: (1) NFI-X, a TF with unknown structure that binds to the palindromic motif TTGGC(n5)GCCAA and plays an essential role in skeletal muscle development; and (2) NF-Y, a histone-like TF that binds the CCAAT box in promoters of cell cycle genes. (1) The …
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Novel mechanism in astrocyte gene regulation and function
… specific gene regulation and function by the NFI-X transcription factor which can be further extrapolated to astrocyte differentiation and glial tumor invasion. First, we cloned and analyzed human NFI-X3, a novel splice variant of the nfix gene, which contains a unique transcriptional …
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Regulation of IGFBP-5 and Osteoblast Functions by Nuclear Factor I
… activator protein 2 (AP-2) and nuclear factor I (NFI). The work in this dissertation identifies the NFI gene family as an important regulator of IGFBP-5 transcription primarily in human, as well as murine osteoblasts. The mechanism of IGFBP5 gene regulation involves direct binding of the NFI …
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A retrospective analysis of nerve function impairment in Hansen's disease cases in the United States National Hansen's Disease Programs
… report the extent of Nerve Function Impairment (NFI) in the upper extremity in the Hansen's disease (HD) (Leprosy) population being diagnosed and treated by the National Hansen's Disease Programs. A retrospective cohort of 197, mean age 47 was examined to determine if the amount of NFI, as …
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Inflammation-associated gene regulation in primary astrocytes, glial tumors and cellular differentiation
… model. We turn our attention to the NFI family of transcription factors since they have recently emerged as novel regulators of the development of vertebral neocortex. We developed a stem cell-neural progenitor-astrocyte differentiation model, in which the generated astrocytes were …
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Design and characterization of a compact voice coil for a needle-free injection device
Conventional needle-free injection (NFI) devices are driven by a pressure source generated by either a compressed spring mechanism or compressed inert gas, which have fixed injection (pressure versus time) profiles. The NFI device developed at the Massachusetts Institute of Technology …
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Needle-free injection nozzle geometry
The development of needle-free injection (NFI) delivery systems has become increasingly important because of the advantages it affords such as increased patient acceptability, enhanced occupational safety for health providers, safe disposal, and increased speed of mass vaccination in the face of …
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The Utility of Depression Screening Measures After Traumatic Brain Injury
… (BDI), Neurobehavioral Functioning Inventory (NFI), The Hamilton Rating Scale for Depression (Ham-D), and the Structured Clinical Interview for DSM-IV TR Axis I Disorders (SCID) in an outpatient neuropsychology clinic at a university medical center, outpatient physical medicine and …
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The influence of perceived brand personality of social media on users' attitude motivations and behaviour
… follows: __2 = 1298.658; d.__ = 510; p = .000; NFI = .846; IFI = .901; TLI = .890; CFI = 900, RMSEA = 0.066 PCLOSE (.000) The brand personality of LinkedIn is represented by two traits: competence and sincerity. The LinkedIn model fit indices were attained at: at: __2 = 1124.7067; d.__ = 478; p …
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Dynamic property evaluation of frother
… Combined with normalized frothability index (NFI), normalized collapse rate constant (NKc), hydrophilic-lipophilic balance (HLB) and dynamic froth index (DFI), IDFI can be a useful index in evaluating the frothability of a solvent tested. Based on correlation between laboratory flotation of …
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Self-Efficacy and Self-Regulation as Predictors of Academic Motivation among Undergraduate Students in the United States
… and poor fit indices were found (GFI = .875, NFI = .874, CFI = .889, RMSEA = .129. SRMR= .090). Therefore, an exploratory analysis was conducted, and modifications made based on modification indices and theory in order to improve the fit indices. The adjusted model showed acceptable fit …
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Home Sweet Home: Epigenetic Paths of Stem Cells In and Out of Their Niche
… regulated, putative stemness genes. I found that NFI transcription factors (NFIB and NFIX) act redundantly in mouse skin to maintain the undifferentiated state of progenitors in hair follicles, sebaceous glands and sweat glands. Combining gene expression and chromatin profiling, I discovered that …
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Examining reasons for participation in sport and exercise using the Physical Activity and Leisure Motivation Scale (PALMS)
… the proposed model of PALMS subscales in a confirmatory factor analysis. This study also looked at the various reasons people nominate for engaging in physical activities. A community sample of 202 volunteer participants, 120 males and 82 females, aged 18 to 71 years, was recruited from …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
<p>We report that ectopic expression of Nfix in primary mouse HSPC extended their ex vivo culture from 20 to 40 days. HSPC overexpressing Nfix displayed hypersensitivity to supportive cytokines and reduced apoptosis when subjected to cytokine deprivation compared to controls. Ectopic Nfix resulted …
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Effects of Zinc Oxide Nanoparticles on the Pharyngeal Pumping and Neurological Behavior of C. elegans
… lev-11, myo-1, myo-2, myo-5, nas-3, nas-15, nfi-1, pha-1, pha-2, pha-4, sod-1 and unc-2. Overall, a majority of the said genes, 17 out of 23, were significantly upregulated. Genes that exhibited significant > 2 fold upregulation include ceh-22, daf-12, drp-1, dyn-1, eat-5, eat-18, F02A9.4, …
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Safe crossing among pedestrians based on extended theory of planned behaviour
… structural model showed GFI, CFI, TLI and NFI were greater than 0.90 and AGFI was less than 0.90. The findings showed that hypothesis testing of all the variables had significant relationship and positive impact on behavioural intention among pedestrians. Therefore, TPB model with extended …
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MMPI-2-RF : clinical utility with a traumatic brain injury population
… and the Neurobehavioral Functioning Inventory (NFI) were examined. Patient demographics and measurement qualities were reported with the sample.
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An Examination of the Influence of Ethnic Identity, Spirituality, and Social Support as Predictors of Resilience among Black Male College Graduates Born in the United States
… an acceptable fit to the data. (GFI =.92, NFI = .91, TLI=.93, and CFI = .94) The Chi-Square value of 257.32, df = 99, RMSEA of .07, and the SRMR of .28 of the initial model required modification, as the criterion for the SRMR index was not met. The respecified model showed a Chi-square …
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An Explanatory Model on Quality of Life in Patients with Hematologic Malignancy
… p=.000, RMSEA=0.076, GFI=0.916, AGFI=0.862, NFI=0.938, CFI=0.966, TLI=0.951, PNFI=0.660). 2. 가설적 모형의 가설 중에서 최종 10개의 가설이 지지되었으며, 가설 검증 결과는 다음과 같다. 1) 증상은 자기효능감과 진단 후 기간에 직접적인 영향을 받으며, 이 변수들에 의해 44.3% 설명되었다. 2) 자가간호행위는 자기효능감, 증상과 사회적 지지에 의해 직접적인 영향을 받으며, 이 변수들에 의해 77.6% 설명되었다. 3) 지각된 건강상태는 …
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