Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"NFE2L2"”.
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Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression
… elevated in lung cancer due to mutations in NFE2L2, the gene that encodes NRF2; and KEAP1, the cytoplasmic regulator of NRF2. Since it became established that elevated NRF2 signalling provides a beneficial role to the tumour through enhancing proliferation, enabling survival in highly …
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Effects of essential amino acids supply and body condition prepartum on antioxidant, inflammation and mechanistic target of rapamycin pathways in adipose tissue during the periparturient period
… Nuclear factor, erythroid-derived 2-like 2 (NFE2L2, formerly Nrf2) is a key transcription factor controlling cellular oxidative stress (OS) in non-ruminants. Our research examined the effects of rumen-protected methionine (RPM) supply or body condition prepartum on pathways associated with …
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Investigating the genetic basis of cisplatin-induced ototoxicity in adult South African patients
… in the genes nuclear factor, erythroid 2-like 2 (NFE2L2) and solute carrier family 22, member 2 (SLC22A2) were identified. SLC22A2 encodes a known transporter of cisplatin, and the variant rs316019 conferred potentially protective effects against Chang- and TUNE-graded ototoxicity through a …
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Analysis of driver gene mutations in oesophageal squamous cell carcinoma
… findings across 67 samples, identifying TP53, NFE2L2, CDKN2A.p16INK4a, ZNF750, and NOTCH1 as OSCC driver genes. Samples clustered into three groups: cluster 1, cluster 2a, and cluster 2b, expanding upon the two clusters identified in our WGS analysis. In both WGS and WES analyses, cluster 1 …
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Microrna involvement in hepatic adaption during the periparturient period in Holstein dairy cows
… expression of nuclear factor erythroid 2-like 2 (NFE2L2) or p-NFE2L2 (both are involved in antioxidant signaling pathways) at any time point in liver tissue. However, LoBCS cows had increased abundance of proteins associated with glutathione metabolism, an antioxidant that is capable of preventing …
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In vitro investigation of the molecular relationship between mitochondrial dysfunction and neurogenesis in autism aetiology
… biogenesis (mitogenesis) (C-MYC, PGC-α, NRF1, NFE2L2, TFAM) and mitochondrial fusion (STOML2, OPA1) genes were performed to identify PPA-responsive genes and to get initial insights on the effect of PPA treatments on transcriptional regulation of mitostasis. Mitochondrial membrane potential …
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An autoregulatory loop between NRF2 and HIPK2 shapes cytoprotective responses
… factor (erythroid-derived 2)-like 2, known as NFE2L2 (gene) or NRF2 (protein), is the primary cellular barrier to counteract the deleterious effects of oxidative stress. NRF2 is a transcription factor that regulates the basal and inducible expression of hundreds of cytoprotective genes to …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
… regulator Nuclear Factor, Erythroid 2 Like 2 (NFE2L2/Nrf2), likely through inactivation of Glycogen Synthase 3β (GSK-3β). Both Nrf2 and Hypoxia-Inducible Factor 1α (HIF-1α) were required for IGF-1-mediated induction of BNIP3. While BNIP3 apparently inhibited cellular macro-autophagy, it …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… in KEAP1 as well as somatic mutation in NFE2L2 has been reported in several human cancers playing a role in the development of such cancer. Using short hairpin RNA (shRNA) and the CRISPR/Cas9 system to generate stable Nrf2 knockdown A549 and H460 cells, the second part of this thesis …
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Endocannabinoid and lipid metabolism genes network analysis in adipose and liver tissue of dairy cows during the transition period
… that are involved in inflammation (TLR9, TLR4, NFE2L2). Expression of CNR2 and NAPEPLD was greater at 7 d in LoBCS due to lower expression at the same time in HiBCS. The expression of FAAH was upregulated at d 7 and 20 in LoBCS than HiBCS cows. Expression of MGLL was overall greater across time …
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Pan-Cancer Genomic Characterization of Human Papillomavirus Associated Tumors
… hotspot mutations were more frequent in HNSC, NFE2L2 hotspots occurred more in CESC and integrated tumors, and PTEN mutations occurred more often in females compared to males. Deletions of chromosome 11q22 frequently occurred in HPV(+) HNSC to inhibit BIRC2/3 and promote immune suppression, …
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Effects of Far Infrared Irradiation on Vascular Function in Healthy Subjects
… factor erythroid 2–related factor 2 (NRF2), NFE2L2 (gene name for NRF2), Kelch-like ECH-associated protein 1 (KEAP1) and endothelial nitric oxide synthase (NOS3) in peripheral blood mononuclear cells (PBMCs) was examined.<b><br/></b><b><br/></b><b>Results</b>: in comparison with baseline, the …
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Enhancing Early Detection of Oesophageal Squamous Cell Carcinoma Through Shallow Whole-Genome Sequencing and Non-Endoscopic Sponge Sampling
… in OSCC development, including CDKN2A (9p), NFE2L2 (2q), TSLC1 (11q), and SOX2 and PIK3CA (3q). This thesis presents the first comprehensive evaluation of a genomic model for OSCC detection, integrating chromosome arm-level CNAs and a novel genomic instability metric—the GWIS—using the …