Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"NFATc2"”.
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The involvement of IRAK-1 in the regulation of NFATc2 in T cells
… also regulates cell-mediated immune responses. NFATc2 (nuclear factor of activated T cells) was found to be associated with IRAK-1 in T cells in vitro and its activity was elevated in the absence of IRAK-1. In addition, IRAK-1-/- mice had increased naturally occurring regulatory T cells and …
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Transcriptional Regulation of the Inducible Costimulator (ICOS) in T Cells
… our data suggests that the Fyn-calcineurin-NFATc2 and MEK2-ERK1/2 signaling axes cooperate to transactivate icos transcription by acting on two different sites of its promoter. In T cells undergoing differentiation, we found that T-bet in Th1 or GATA-3 in Th2 cells could enhance, and NFATc2 …
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DELINEATING REGULATORY PATHWAYS OF NOVEL CANCER STEM CELL MARKER, DCLK1-S, FOR TARGETING COLON CANCER STEM CELLS
… mediates the activity of transcription factor, NFATC2 (via the NFATC2 53SPPS56 motif), which in turn results in NFATC2 binding and activation of the COL3A1 promoter which enhances the invasive potential of colon cancer cells. The 5’(α)-promoter is differentially methylated in normal human colons …
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The RNA-Binding protein PTBP1 plays a role in the activation of mouse CD8 T cells
… and Ag may be linked to translocation of c-Fos, NFATc2 and NFATc3 in the nucleus of T cells. These findings reveal a crucial role for PTBP1 in regulating post-transcriptional regulation of genes involved in CD8 T cell activation and effector functions.
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Epigenetic repression of the NFATc1 transcription factor in human lymphomas
… expression is unaffected by TCR signals, and NFATc2 was found to be expressed at normal levels in ALCLs and cHLs (L.K., unpubl. data). Moreover, the activity of NF-kappaB factors which can bind to certain NFAT binding sites and share a distantly-related DNA binding domain with NFATs is …
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The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells
… with IRF4. Our data shows that PU.1, IRF4 and NFATc2 form a complex in Th2 nuclear extract. We also demonstrated by ChIP assay that IRF4 directly binds the Il10 and Il4 loci in a time dependent manner. The role of these protein-protein and protein-DNA complexes and their contribution towards …
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Die Hämatopoetische Progenitor Kinase (HPK) 1 und NFAT-Transkriptionsfaktoren unterstützen die Apoptose von T-Lymphozyten
… (auch NFATc1 oder NFAT2 genannt) und NFATp (NFATc2 oder NFAT1) werden in peripheren T-Zellen stark exprimiert und kontrollieren deren Effektorfunktionen u.a. über die Expression von IL-2, IL-3, IL-4, IL-5, IFNgamma und weiterer Lymphokine. Weitere von den NFAT´s kontrollierte Gene sind …