Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"NFATc1"”.
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Epigenetic repression of the NFATc1 transcription factor in human lymphomas
We examined the regulation of NFATc1 in different lymphomas and observed an inversed correlation between the methylation status and expression of NFATc1. Our data demonstrate that aberrant DNA methylation associated with chromatin remodeling within nfatc1 locus is a major mechanism for the …
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Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation
… degenerative disorders. Therefore, the level of NFATc1, the master transcription factor of osteoclast, must be tightly controlled. Although the activation and amplification of NFATc1 have been extensively studied, how NFATc1 signaling is eventually resolved is unclear. Here, we uncover a novel …
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Regulation des Blimp1-Promotors durch die Transkriptionsfaktoren C/EBP-Beta und NFATc1 in T-Lymphozyten
… factor of activated T cells) Bindungsmotiv. Auch NFATc1 bindet direkt, entwickelt aber kein transaktivierendes Potential sondern reprimiert vielmehr die durch C/EBPβ-vermittelte Transaktivierung.
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In Vitro and In Silico Analysis of Osteoclastogenesis in Response to Inhibition of De-phosphorylation of EIF2alpha by Salubrinal and Guanabenz
… cells and downregulated the expression of NFATc1, a master transcription factor of osteoclastogenesis. Silencing eIF2alpha by RNA interference suppressed the downregulation of NFATc1, suggesting the involvement of eIF2alpha in regulation of NFATc1. Second, the in silico results using …
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Identifying notch-regulated genes using a specific notch signaling inhibitor
… and immune gene networks. Notably, NFATc1, CYC1, and ITGB3 emerged as strong responders to Notch inhibition, whereas Hes1, a classical notch target, showed stable expression, indicating possible compensatory regulation. Functional assays confirmed that DAPT strongly inhibited …
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Effect of blueberry polyphenols on osteoclast
… factor of activated T-cells, cytoplasmic 1 (NFATc1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were determined. Blueberry polyphenols were shown to be effective by decreasing iNOS, COX-2 and TRAP levels. This study indicates that blueberry polyphenols decrease …
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The in vitro effects of diallyl trisulfide on osteoclast formation and function in RAW 264.7 murine macrophages
… factor of activated T-cells cytoplasmic 1 (NFATc1) expression crucial for osteoclastogenesis. While ERK protein expression remained unchanged, the significant reduction in P38 protein expression at 5 minutes of RANKL exposure could diminish NFATc1 levels, thereby reducing osteoclast …
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
… a significant reduction in the nuclear levels of NFATc1 and NFATc3 in dCam/PKB cells.Downregulation of nuclear NFAT levels by myrPKB thus seems to be an essential parameter in dCam cells to proceed with normal differentiation. In summary, the data from PKB tg peripheral CD4+ T cells and dCam/PKB …
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An evaluation of genomic factors and their importance in etiopathogenesis of congenital heart diseases /
… – FGF9, BMPR1A, PTEN, ANKRD17, NPPA, LMNA, NFATC1 and IFT88. Five de novo deletions and one deletion of maternal origin encompassed aforementioned genes. This piece of research revealed that rare genetic CNVs (rare deletions and duplications) manifested themselves 2.65 times more frequently …
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Genominių veiksnių įvertinimas ir reikšmė įgimtų širdies ydų etiopatogenezėje /
… – FGF9, BMPR1A, PTEN, ANKRD17, NPPA, LMNA, NFATC1 and IFT88. Five de novo deletions and one deletion of maternal origin encompassed aforementioned genes. This piece of research revealed that rare genetic CNVs (rare deletions and duplications) manifested themselves 2.65 times more frequently …
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The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts
… SNP rs2887571 has less binding of ERα and NFATc1 to allele A than allele G, resulting in more expression of WNT5B in homozygous AA than homozygous GG. Furthermore, WNT5B exhibits distinct effects from other WNTs on osteoblastogenesis. WNT5B increases mesenchymal stem cell proliferation, …
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Studies of the role of nf-κb in controlling osteoclast differentiation and bone loss
… NF-κB p50 and p52 followed by c-Fos and then NFATc1 to induce OC differentiation. However, TNF alone nduces very limited OC differentiation. In contrast, it pre-activates OCPs to express cFos which cooperates with interleukin-1 (IL-1) produced by these OCPs in an autocrine mechanism by …
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Ο ρόλος κυτταροκινών και βιοχημικών οδών ενδοκυττάριας σηματοδότησης στην παθογένεια των φλεγμονωδών αρθριτίδων
… και NFκ-B) και των μεταγραφικών παραγόντων (NFATc1 και c-jun), που είναι αναγκαία για την ευόδωση της οστεοκλαστογένεσης. Τα ευρήματά μας, σε συνδυασμό με τις κατασταλτικές δράσεις της στα Τ-λεμφοκύτταρα, υποδεικνύουν ότι η IL-27 θα μπορούσε ίσως να θεωρηθεί μια ελκυστική θεραπευτική …
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Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha
… The NFAT family consists of four isoforms (NFATc1-c4), all of which depend on dephosphorylation by the Ca2+/calmodulin-dependent phosphatase calcineurin to translocate to the nucleus where it binds to DNA in order to induce changes in gene expression. We demonstrate that high glucose …
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PKB/Akt : a critical regulator of lymphocyte, development and function
… of peritoneal B-1 cells. However, expression of NFATc1, which is required for B-1 cell development, was comparable between wt and myr PKB tg B-1 cells. To analyse the effect of myr PKB on immunoglobulin production, mice were immunized with thymus dependent (TD) and independent (TI) antigens. In …
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Die Hämatopoetische Progenitor Kinase (HPK) 1 und NFAT-Transkriptionsfaktoren unterstützen die Apoptose von T-Lymphozyten
… gemeinsam ist. NFATc (auch NFATc1 oder NFAT2 genannt) und NFATp (NFATc2 oder NFAT1) werden in peripheren T-Zellen stark exprimiert und kontrollieren deren Effektorfunktionen u.a. über die Expression von IL-2, IL-3, IL-4, IL-5, IFNgamma und weiterer Lymphokine. Weitere von den …
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THE CRITICAL ROLE OF CD4+ TH CELLS IN CD8+ CTL RESPONSES AND ANTI-TUMOR IMMUNITY
… (Bcl-2) and down-regulation of proapoptotic (NFATc1, Bcl-10, Casp-3, Casp-4, Casp-7) genes/ molecules. Finally, helped CTLs were also able to induce protection against highly metastasizing tumor challenge, explaining why memory CTLs generated under cognate Th1’s help show survival and recall …