Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"NFAT"”.
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Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha
… factor nuclear factor of activated T-cells (NFAT) and the inflammatory cytokine tumor necrosis factor alpha (TNFalpha) in the vascular response to hyperglycemia. NFAT is a Ca2+-dependent transcription factor which was originally described in immune cells. The NFAT family consists of four …
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Hemmung des nukleären Transkriptionsfaktors aktivierter T-Lymphozyten (NFAT) durch Barbiturate : Mechanismus und Wirkung
… des nukleären Faktors aktivierter T-Lymphozyten (NFAT) untersucht werden, ein weiterer zentraler Regulator der Immunantwort, der die Transkription zahlreicher Zielgene aktiviert. <br>Alle Experimente wurden mit primären humanen CD3-positiven (CD3+) T-Lymphozyten durchgeführt, deren …
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Die Hämatopoetische Progenitor Kinase (HPK) 1 und NFAT-Transkriptionsfaktoren unterstützen die Apoptose von T-Lymphozyten
… Die Nukleären Faktoren aktivierter T-Zellen (NFAT´s) gehören zu einer Familie von Transkriptionsfaktoren, denen eine konservierte, ca. 300 Aminosäuren (aa) große DNA-Bindedomäne und eine Calcineurin-Bindedomäne gemeinsam ist. NFATc (auch NFATc1 oder NFAT2 genannt) und NFATp (NFATc2 oder NFAT1) …
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Regulation of the Nuclear Factor of Activated T Cell (NFAT) Family of Transcription Factors in the Freeze Tolerant Wood Frog, Rana sylvatica
… of the nuclear factor of activated T-cells (NFAT) transcription factors, isoforms c1-c4, was analyzed in liver and skeletal muscle over freeze/thaw and anoxia/re-oxygenation cycles. Freezing activated NFATc3 in liver, leading to increased osteopontin expression and glycogen synthase kinase 3β …
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FHL2 Inhibits Calcineurin and Represses Pathological Cardiac Hypertrophy
… relies on activation of the calcineurin-NFAT pathway, and inhibition of calcineurin is sufficient to block growth in response to isoproterenol. I also observed that FHL2 is up-regulated in mouse hearts after isoproterenol treatment. Based on this, we hypothesized that FHL2 negatively …
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
… a drastically reduced nuclear translocation of NFAT proteins and this is due to a direct interaction between PKB and NFAT. To study whether the negative regulatiopn of NFATs by PKB affects T cell development, we analyzed double tg mice expressing both, a constitutively active version of …
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Role of the Plasma Membrane Calcium ATPase as a Negative Regulator of Angiogenesis
… calcineurin/nuclear factor of activated T-cell (NFAT) pathway. Inhibition of calcineurin activity by the drug cyclopsorin A (CsA) has been shown to inhibit processes required for successful angiogenesis such as in vitro cell migration, tube formation and additionally attenuates corneal …
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Gene regulation and hypertroipc responses in age-matched control and STZ-treated rats
… were isolated from the hearts and stained for NFAT and calcineurin. NFAT was identified by immunohistochemistry and calcineurin was quantitative analysed and measured by technique of Western Blotting. Statistical analysis was done by Mann Whitney U test for two independent samples using SPSS …
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The Suppressive Mechanisms of TIM3 on T Cell Cytokine Production and The Anti-Tumor Effect of TIM3-Pathway Inhibition
… TIM3-over expression reduced the activities of NFAT and AP-1, important transcription factors of IL-2 expression. The expression of c-Jun and dephosphorylation of NFAT were suppressed by TIM3 expression. The 7 a.a from E261 to I267 of TIM3 cytoplasmic tail was critical for down-regulation of …
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Characterization of the Tetraspanin protein Tspan18
… of Tspan18 in lymphocyte cell lines activated an NFAT/AP-1 reporter, which responds to calcium and MAPK signalling. In DT40 B cell lines, Tspan18 signalling was independent of Lyn, Syk, PLC2 and IP3 receptors, which are essential for B cell receptor signalling. However, Tspan18 signalling did …
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Patients with adrenal adenomas and autonomous cortisol secretion. Impact of hypercortisolism on skeletal and adipose tissue mass, measured in abdominal computed tomography
… patients with a non-functioning adrenal tumor (NFAT) were included. Methods: Medical records were reviewed and body composition measurements (visceral fat [VAT], subcutaneous fat [SAT], visceral/total fat [V/T], visceral/subcutaneous [V/S] and total abdominal muscle mass) were calculated based …
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Regulation des Blimp1-Promotors durch die Transkriptionsfaktoren C/EBP-Beta und NFATc1 in T-Lymphozyten
… der P1/Pu-bB-des IL-4-Promotors ähnliche NFAT/C/EBP-Bindungssequenz. Die C/EBP-Bindungsstelle liegt hierbei in direkter Nachbarschaft zum NFAT-(nuclear factor of activated T cells) Bindungsmotiv. Auch NFATc1 bindet direkt, entwickelt aber kein transaktivierendes Potential sondern …
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A NOVEL SELECTIVE INHIBITOR FOR PLASMA MEMBRANE CALCIUM ATPase 4 IMPROVES VEGF-MEDIATED ANGIOGENESIS
… VEGF-mediated activation of the calcineurin/NFAT signalling pathway has been identified as a crucial regulator of angiogenesis. Our laboratory has recently shown a novel role for the plasma membrane calcium ATPase 4 (PMCA4) protein as a negative regulator of VEGF-induced angiogenesis via …
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
… able to demonstrate that there are functional NFAT (nuclear factor of activated T cells) and MEF2 (myocyte-specific enhancer factor 2) binding sites within the enhancer of troponin I slow, and both sites are required for slow fiber specific activity of this enhancer. Next, I identified MEF2 as …
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Sevofluran hemmt die DNA-Bindung des Transkriptionsfaktors Aktivator Protein-1 und induziert Apoptose in T-Lymphozyten
… DNA-Bindung der Transkriptionsfaktoren AP-1, NFAT, NF-kappaB, SP-1 und <br>Oct-1 wurde mit PMA und Ionomycin induziert. Im EMSA konnte erstmals eine <br>zeit- und dosisabhängige Hemmung der DNA-Bindungsaktivität des <br>Transkriptionsfaktors AP-1 nach Inkubation mit Sevofluran nachgewiesen …
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PMCA as a regulator of calcium/calmodulin-dependent signal transduction pathways
… PMCA4 has already been shown to inhibit the NFAT family of transcription factors by its interaction with calcineurin A in mammalian cells when ectopically expressed. This prompted the investigation into other isoforms of PMCA that may interact with the calcium/calmodulin-dependent …
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The Cross-Talk Between Neurons and Microglia Through Interleukin-4 After Ischemic Injury
… and nuclear factor of activated T cell (NFAT) as potential players in the transcriptional regulation of the IL-4 synthesis in neurons. Finally, using neuron conditioned medium transfer to microglia, we find that neuronal IL-4 is capable of polarizing microglia toward a restorative, …
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Tsyn-Seq: A T Cell Synapse-Based Antigen Identification Platform
… with a nuclear factor of activated T cells (NFAT) reporter. To functionally screen for target antigens from a cDNA library, productively interacting T cell–APC aggregates were detected by dual reporter activity and enriched by flow sorting followed by antigen identification quantified by deep …
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Investigating Karyopherin B1: small molecule interactions for cancer therapy
… of ≈10μM and induces apoptotic cell death. The NFAT dual luciferase assay measured nuclear import of KpnB1 associated proteins, showing that INI-43 inhibits nuclear import/activity of NFAT in a dose dependent manner. Confocal microscopy of exogenous FRFP-KpnB1 as well as endogenous KpnB1 in the …
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