Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"NF-kappaB"”.
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Aktivierung des nukleären Transkriptionsfaktors kappaB (NF-kappaB) durch Verapamil
… von Bestandteilen des Transkriptionsfaktors NF-kappa B und dessen Inhibitorprotein IkappaB durchgeführt. Des weiteren wurden EMSAs zur Aktivitätsbestimmung des Transkriptionsfaktors NF-kappa B durchgeführt. Bei den kardialen Schweinefibroblasten konnte eine Aktivierung des …
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Haploid reporter screens aimed at identification of NF-kappaB regulators
Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such as cell survival, differentiation, proliferation, and inflammation. …
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Role of the NF-kappaB-HIF Crosstalk in Inflammation and Hypoxia
… HIF has recently been associated with a role in inflammation and immunity. Importantly, HIF-1alpha has shown to be regulated by the major inflammatory responsive transcription factor, NF-kappaB (nuclear factor kappaB). Here it is demonstrated that hypoxia also activates NF-kappaB in the context of …
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Die Rolle des Transkriptionsfaktors NF-KappaB in Influenza-A-Virus infizierten Zellen
Die Aktivierung von Transkriptionsfaktors NF-kB ist ein Charakteristikum viraler Infektionen, einschließlich der Infektion durch Influenza-A-Viren (Hiscott J. et al., 2001). Da die Expression vieler proinflammatorischer und antiviraler Zytokine, wie IFNb oder TNF-a durch NF-kB kontrolliert wird, …
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Expression des Transkriptionsfaktors NF-kappaB in Zellen des Hodgkin-Lymphoms und des großzelligen anaplastischen Lymphoms
… Arbeit war es, zum einen Unterschiede in der NF-kappaB-Zusammensetzung zwischen HD- und LCAL-Zelllinien und zum anderen anhand der NF-kappaB-Verteilung das in der Literatur beschriebene Verhalten der jeweiligen Zellen bezüglich Proliferation und Apoptose zu analysieren. In beiden untersuchten …
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Investigating the role of intra- and extra-cellular modulators of the transcription factor NF-kappaB
The nuclear factor-kappa B (NF-kappaB) family of transcription factors play a pivotal role in the inflammatory and immune responses, as well as cell growth and survival. Since its discovery 25 years ago, NF-kappaB has emerged as one of the most intensely studied eukaryotic transcription factors, …
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The non-canonical NF-kappaB pathway as a novel player in beta cell dysfunction in diabetes
… type-1 and type-2 diabetes. The non-canonical NF-κB pathway has recently garnered attention at being involved in the development of peripheral insulin resistance (liver, muscle) in diabetes. Whether pancreatic β cell non-canonical NF-κB signalling contributes to glucose homeostasis and diabetes …
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Die Rolle des IKK/NF-kappaB Signalweges bei der Myelinisierung, De- und Remyelinisierung des zentralen Nervensystems
… es darum, die funktionelle Rolle des klassischen NF-kappaB Signalweges bei der Entwicklung (Myelinisierung), Schädigung (Demyelinisierung) und Regeneration (Remyelinisierung) des Myelins im zentralen Nervensystem (ZNS) aufzuklären. De- und Remyelinisierung sind Prozesse, wie sie bei Erkrankungen …
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Beeinflussung der Aktivität von NF-kappaB durch gram-negative Bakterien - ein Beitrag zur Pathogenese der reaktiven Arthritis
Beeinflussung der Aktivität von NF-kappaB durch gram-negative Bakterien - ein Beitrag zur Pathogenese der reaktiven Arthritis Als Beitrag zur Pathogenese der reaktiven Arthritis wurde die Aktivierung von NF-kB durch gram-negative Bakterien untersucht. Mittelpunkt dieser Arbeit war die Beobachtung, …
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CRSPR manipulation and nutritional status reveal functions of transcription factor NF-kappaB in the sea anemone Nematostella vectensis
… RNA sequencing, genes encoding proteins in the NF-κB signaling pathway have been discovered in a variety of early-branching organisms. Although knowledge of the evolution of NF-κB signaling and the immune system continues to grow, many gaps remain in our understanding of relevant complex gene …
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The Effect of Interleukin-1 (IL-1) Concentration on Single Cell NF-kappaB Activation in a Gradient-Generating Microfluidic Device
… IL-1 plays an integral role in the immuno-inflammatory response of the body to a variety of stimuli including infection, trauma and other bodily injuries. Once IL-1 is released from the synthesizing cell, it acts as a hormone, initializing a variety of responses in different cells and …
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Regulation of BACE1 promoter activity by nuclear factor-kappaB\r\n
… for the generation of beta-amyloid peptides. The NF-kappaB binding DNA consensus sequence in the BACE1 promoter upstream of the gene’s transcription start site suggests a role for NF-kappaB in the expression of neuronal brain BACE1. Failure of activation of NF-kappaB responses to stress in the …
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PHOSPHORYLATION OF NF-ΚB RELA/P65 ON SER536 SIGNALS CANCER CELLS TO DEATH AND ENHANCES CHEMOSENSITIVITY
RelA/p65 is a main subunit of nuclear factor-kappaB (NF-kappaB) that regulates expression of genes involved in cell growth and survival, stress response, and inflammation, but its oncogenic or tumor-suppressive function in tumorigenesis has been highly controversial. Hundreds of NF-kappaB …
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Characterization of the Glycosylation and Signal Peptide Sequences Within the Vaccinia Virus M2 Protein and Influence on ERK1/2 and Nf-Kappab Activation
… immunomodulator to inhibit both the ERK1/2 and NF-kappaB pathways, which is reliant on its glycosylation status and proper cellular trafficking within the infected cell. As M2 has no homology to any known viral or cellular protein, this suggests a novel immunoregulatory function. Data contained …
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Modulators of Inflammation and Steroid Receptors Regulate Proteinase Inhibitor 9 Gene Expression
In addition to pro-inflammatory agents, the synthetic anti-inflammatory glucocorticoid, dexamethasone, induced PI-9 gene expression via an imperfect glucocorticoid response element (GRE) located at -208. Dexamethasone induced PI-9 mRNA and protein. Dexamethasone-glucocorticoid receptor (GR) complex …
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Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein
… of the MC160 protein independently inhibit TNF-mediated NF-kappaB activation. Specifically, we observed that the second DED of MC160 interacts with procaspase-8 as a means to inhibit NF-kappaB activation, while the C-terminus of MC160 interacts with the chaperone Hsp90. Because both …
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The role of the chromatin protein HMGN3 in cytokine induced gene expression
… chromatin structure by binding to chromatin, unfolding nucleosome arrays and altering the pattern of histone modifications. HMGN3 is unique amongst the HMGN family as two splice variants are produced from the HMGN3 transcript. HMGN3 was shown to regulate TNFα-induced expression of the murine …
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