Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"NF-kappa B"”.
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Ubiquitin Mediated Regulation of NF-kappa B Signaling
NF-κB signaling is involved in many vital cellular functions such as immunity, cell proliferation, inflammation, and apoptosis. The activation of NF-κB signaling requires the process of ubiquitination. K63-and K48-linked ubiquitin chains have been shown to have distinct roles and biological …
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Inhibition des nukleären Transkriptionsfaktors kappa B (NF-Kappa B) durch die kurzkettige Fettsäure Butyrat
… entzündlichen Prozessen ist der nukleäre Faktor kappa B (NF-kappa B) an der transkriptionellen Regulation proinflammatorisch wirkender Genprodukte beteiligt. Durch Mediatoren wie TNF alpha oder IL-1 beta wird eine nukleäre Translokation von normalerweise im Zytoplasma an inhibitorische I kappa …
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Funktion von NF-kappa B für die Differenzierung lymphoider Zellen und die inflammatorische Aktivierung von Endothelzellen
Die Aktivität des Transkriptionsfaktors NF-kappa B wird hauptsächlich durch inhibitorische I kappa B-Proteine kontrolliert,die durch die I kappa B-Kinasen 1 und 2 phosphoryliert und anschließend degradiert werden.Dadurch werden ver-schiedene zelluläre Prozesse wie Differenzierung und Aktivierung …
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Repression of Protein Kinase C Delta in Human Squamous Cell Carcinomas by Ras, Fyn and NF-Kappa B Signaling
… activity by activation of nuclear factor kappa B (NF-kB) and recruitment of repressive NF-kB subunits (p50 and c-Rel).</p><p>We also found that Fyn tyrosine kinase activation was necessary and sufficient for NF-kB activation and PKC-delta repression. In addition, Fyn was over-expressed in …
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Modulation of host NF-[k̳̳a̳p̳p̳a̳]B pathway by the Toxoplasma gondii secreted factor, GRA15
… is an obligate intracellular pathogen that infects all warm blooded animals, including nearly thirty percent of the human population worldwide. Toxoplasma's success as a parasite owes largely to its ability to commandeer its host's immunologic and metabolic processes for its own benefit. …
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Der Einfluß der Outer surface proteins von Borrelia burgdorferi auf die Transkriptionsfaktoren NF-kB und AP-1
… mit der Aktivierung des Transkriptionsfaktors NF-kappa B. In dieser Arbeit sollte untersucht werden, inwieweit sich Osp A, Osp B und Osp C bei dieser Reaktion unterscheiden. Als Testsystem wurde ein EMSA zum Nachweis der aktivierten Transkriptionsfaktoren NF-kappa B und AP-1 verwendet. <br>Die …
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Aktivierung des nukleären Transkriptionsfaktors kappaB (NF-kappaB) durch Verapamil
… von Bestandteilen des Transkriptionsfaktors NF-kappa B und dessen Inhibitorprotein IkappaB durchgeführt. Des weiteren wurden EMSAs zur Aktivitätsbestimmung des Transkriptionsfaktors NF-kappa B durchgeführt. Bei den kardialen Schweinefibroblasten konnte eine Aktivierung des …
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Host cell signaling in response to RSV infection
RSV infection is the most important cause of hospitalization of infants, and is also the major cause for admissions in adults with chronic cardiac disease and pulmonary diseases. So far, there is no effective treatment or vaccine against RSV infection. Intensive studies have been performed to …
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The role of NF-kB2 in secondary and tertiary lymphoid tissue development
The role of the alternative NF-\(\kappa\)B pathway in the development of secondary lymphoid organs (SLOs) has been well described. Tertiary lymphoid organs (TLOs) include intestinal cryptopatches (CPs) and isolated lymphoid follicles (ILFs). This thesis investigates the role of the alternative …
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Aktivierung phagozytierender Zellen durch "Advanced Glycation Endproducts" und beta-Amyloid-Implikationen für die Pathogenese der Alzheimer'schen Demenz
… auf die Translokation des Transkriptionsfaktors NF-kappa-B in den Zellkern überprüft wurden. In der vorliegenden Arbeit wurden die Rahmenbedingungen näher untersucht, die zu der AGE vermittelten Mikrogliaaktivierung führen. Es wurde in vitro gezeigt, daß die Mikrogliaaktivierung zunächst durch …
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The A2A adenosine receptor: its role in suppressing vascular inflammation and its regulation by phosphorylation
Endothelial inflammation leading to vascular dysfunction is a major contributor to the development of atherosclerosis. The release of adenosine at sites of inflammation represents an endogenous mechanism for limiting excessive inflammation and tissue damage. The majority of the anti-inflammatory …
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2D layout of bead based thioaptamer/aptamer selection platform for therapeutics and diagnostics
… assays, a model system is first established: NF-kappa B proteins were expressed, purified and characterized. Thioaptamer XBY6, which specifically targets NF-kappa B protein, and its natural origin, I-kappa B were synthesized and verified. Thioaptamer purification using FPLC and HPLC was also …
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Comprehensive single and paired drug target identification in healthy and disease models of NF-kB pathway
Nuclear NF-[kappa]B ("NF-[kappa]Bn") is a transcription factor responsible for regulating many genes that play important roles in inter- and intra-cellular signaling, cellular stress responses, cell growth, survival and apoptosis. Defective levels of NF-[kappa]Bn has been associated with cancer, …
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Oral epithelium in the pathogenesis of periodontitis
… (P. gingivalis and F. nucleatum) in terms of NF-\(\kappa\)B activation, differential gene expression and cytokine production. The pathogenesis of periodontitis suggests that susceptible patients exhibit a hyper-inflammatory response to plaque bacteria, so an attempt to modulate the …
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SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
… to be a negative regulator of PPAR[gamma] and NF[kappa]B, two transcription factors important for the differentiation of osteoblasts and osteoclasts, respectively. Here, we show that SirT1 is an important regulator of bone mass in vivo: SirT1 whole-body knockout mice display significant bone …
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Development of Novel anti-estrogens for endocrine resistant Breast Cancer
… of estrogen receptor. ER mediates strong anti-inflammatory signaling in ER+ tissues. Once activated with estradiol (E2), ER inhibits inflammatory gene expression via protein-protein interactions that block NF-kappa B transcriptional activity. Importantly, NF-kappa B is a primary mediator of …
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Modulation of innate immune signaling pathways by the intracellular pathogen Toxoplasma gondii
… most successful eukaryotic pathogens. It can infect virtually any warm-blooded animal, including humans, in whom it can cause serious disease. Its success is likely due to its ability to modulate host immune responses and host innate immune signaling pathways allowing it to establish a chronic …
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Understanding Host Antiviral Signaling Pathways
… is the first line of defense against viral infections. Recent studies have revealed two immune receptor systems that detect virally-derived nucleic acids and trigger signaling pathways which lead to the activation of transcription factors like nuclear factor-kappa B (NF-kappa B), interferon …
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Upstream conserved sequence element that regulates TIM-3 induction in CD4+ T cell
… of CNS -63 was abrogated by mutation of putative NF-κB binding sites between -63423 and -63433. These results indicate that TIM-3 CNS -63 may regulate TIM-3 transcription in human CD4+ T cells.
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