Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 190 for “"NF-kB"”.
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Noncanonical NF-KB in Gastrointestinal Disease
Noncanonical NF-KB is an alternative NF-KB pathway that is critically involved in the development and maturation of the adaptive immune system. As such, it has typically been studied in B and T cell biology without application to complex organ systems such as the gut. The following work explores …
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Overactive NF-KB signaling as a druggable target and evaluation of parthenolide an NF-KB inhibitor in canine cancer
… stand to benefit both canine and human patients. NF-kB proteins are a family of structurally related, eukaryotic transcription factors that have 400+ genetic targets, and are involved in many vital cellular processes, including innate immunity, inflammatory responses, development, cellular growth, …
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ROLE OF P50 NF-KB IN MACROPHAGE MIGRATION
… such as a massive accumulation of the p50 NF-B homodimer in the nucleus and the incapacity to express strong inflammatory programs (eg. impaired TNF production) in response to inflammatory signals such as LPS (tolerance). Our recent study has described that both TAM and LPS-tolerant …
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Modulation de NF-kB par Lactobacillus helveticus R389
"L'huître américaine, Crassostrea virginica, est non seulement une espèce d'importance écologique de nos baies et estuaires, mais une espèce qui démontre aussi un potentiel économique important pour plusieurs régions côtières de l'Est du Canada. Au Canada atlantique, l'une des populations …
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Roles of NF-kB in spinal cord injury pathophysiology
… affected after SCI is the transcription factor NF-kB. We used two-month-old male rats and subjected them to a contusion spinal cord injury to elucidate the differential changes in NF-kB subunits and NF-kB-dependent changes after SCI. We observed an increase in cell death 12 hours after SCI, with …
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Cis and Trans, p53 and NF-kB rules of transactivation
p53 and NF-kB families of Transcription Factors (TFs) are among the most studied proteins in tumour biology, typically known to function as antagonists, although recent studies identified example of positive, even cooperative interactions. p53 and NF-kB act as dimer or dimer of dimers, bind cis …
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ATM REGULATES THE NF-kB PATHWAY VIA RELA SER 276 PHOSPHORYLATION
… found ATM serves as an essential regulator of TNF-and RSV- induced NF-kB pathway. We observed that TNF exposure of cells rapidly induced DNA double strand breaks and activates ATM. TNF-induced ROS promote nuclear IKKr-ubiquitin association and complex formation with ATM for nuclear export. …
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OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling
… revealed, including the nuclear factor-kappa B (NF-kB) pathway. Transcription factor NF-kB is widely involved in cancer development and progression, and its overactivation renders chemoresistance to TNBC and induces aberrant inflammation. Therefore, targeting NF-kB becomes a feasible strategy to …
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NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity
… This eventually culminates in end-organ infiltration and increased patient morbidity and mortality. In mice where the gene Map3k14 encoding NF -kB inducing kinase (NIK) is knocked out, a HES-like syndrome develops that is dependent on Th2 cells and cytokines. NIK is the upstream regulator …
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Untersuchung der Helicobacter pylori-vermittelten Aktivierung des Immunmodulators NF-kB in Magenepithelzellen
H. pylori aktiviert in Magenepithelzellen NF-kB, was zu einer gesteigerten IL-8-Sekretion und zum Einwandern neutrophiler Granulozyten führt. Die wichtigste Voraussetzung für die NF-kB Aktivierung ist das Vorhandensein der Pathogenitätsinsel cagPAI, welche für ein Typ-IV-Sekretionssystem codiert. …
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Cell-surface Tumoricidal Molecules and NF-kB in the Tumor-burdened Host
… microenvironment. Tumor necrosis factor (TNF)-a is both secreted by and expressed on the cell-surface (mTNF-a) of macrophages. When stimulated with LPS, tumor-burdened host (TBH) macrophages secrete more TNF-a than normal host (NH) macrophages. In this study, I showed that mTNF-a is …
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RESPIRABLE SIRNA TARGETING AT THE NF-KB PATHWAY PROTECTS AGAINST INFLAMMATORY LUNG DISEASES
… obstructive pulmonary disease (COPD) are common inflammatory pulmonary diseases. Cumulative evidences have shown the role of NF-kB signaling pathway in the pathogenesis of asthma and COPD. Ribosomal protein S3 (RPS3) is a subunit of NF-kB complex while receptor-interacting protein 2 (Rip2) is a …
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IL-1 activation of NF-kB contributes to perinatal hypoxia/ischemia induced cell death
… a 7-day-old rat model to elucidate the role of NF-kB in HI stimulation of IL-1 signaling. HI was induced by permanent ligation of the left carotid artery followed by 90 minutes of hypoxia (7.8% O2). We observed increased cell death and caspase 3 activity in the hippocampus and the cortex 3 to …
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Untersuchung der durch den Transkriptionsfaktor NF-kB vermittelten ER-Overload Response bei Zystischer Fibrose
… den das mutante DF508-CFTR zu den beobachteten Infektionen und Entzündungen der Lunge führt, noch ungeklärt. <br> Kürzlich wurde ein neuer Signaltransduktionsweg zwischen dem ER und dem Zellkern beschrieben, die ER-Overload Response (EOR). Die EOR wird durch die Akkumulation von un- oder …
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Regulation of Antimicrobial Peptide Genes in Insects by the Toll Pathway and NF-kB Transcription Factors
… melanogaster against bacterial and viral infections. Chapter 3 depicts a new constitutively active short relish isoform lacking inhibitory domain in D. melanogaster that functions towards providing protection to low load of infection. Chapter 4 illustrates the role of a transcription factor …
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Comprehensive single and paired drug target identification in healthy and disease models of NF-kB pathway
Nuclear NF-[kappa]B ("NF-[kappa]Bn") is a transcription factor responsible for regulating many genes that play important roles in inter- and intra-cellular signaling, cellular stress responses, cell growth, survival and apoptosis. Defective levels of NF-[kappa]Bn has been associated with cancer, …
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