Global ETD Search
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Showing 1 to 6 of 6 for “"NF-YA"”.
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NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS
NF-Y is a pioneer transcription factor that regulates the expression of genes involved in cell cycle progression and metabolism. It is composed of: NF-YA, NF-YB and NF- YC subunits. NF-YA recognizes and binds to the CCAAT box, a DNA element found enriched in the promoters of cancer-specific genes …
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THE ALTERNATIVE SPLICING OF NF-YA REGULATES MOUSE EMBRYONIC STEM CELLS DIFFERENTIATION
… entire organism. An example of these factors is NF-Y, a heterotrimeric pioneer TF promoting chromatin accessibility to other TFs to regulate gene expression. The regulatory subunit of NF-Y, NF-YA, recognizes and binds the CCAAT box motif, one of the most enriched DNA elements in enhancers and …
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THE MESENCHYMAL IDENTITY OF NF-YA LONG ISOFORM: FROM VERTEBRATE EVOLUTION TO CANCER
NF-Y è un fattore di trascrizione pioniere altamente conservato, composto dalle subunità NF-YB/NF-YC, contenenti lo “histone fold domain” (HFD), e dal regolatore NF-YA. NF-YA riconosce il CCAAT box sul DNA, un motivo diffuso nei promotori di importanti geni coinvolti nella proliferazione …
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Regulation of the Insulin-like Growth Factor 1-Secretory Clusterin Expression Axis in Genomic Instability and Cell Stress
… in cancer did not repress IGF-1 and sCLU. An NF-Y binding site in the IGF-1 promoter was essential for p53 suppression, and both p53 and NF-YA bound to the IGF-1 promoter. Nutlin-3, an Mdm2-p53 inhibitor, stabilized p53 expression, leading to dramatically decreased sCLU expression. Nutlin-3 …
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The Influence of DNA Methylation on Both H2A.Z Nucleosome Dynamics and the Zinc Finger and Homeoboxes Transcription Factor Family
… heritable modification that exerts substantial influence on chromatin organization and function in many eukaryotic genomes. The presence of DNA methylation has been strongly linked to transcriptional regulation, in both activating as well as repressive ways, though exactly how a small chemical …
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FUNCTIONAL STUDY OF THE NONCODING REGULOME OF THE NUCLEAR FACTOR Y IN HUMAN CANCER
… caratteristiche aggressive dei tumori. Infatti, l’accorciamento della regione 3’ non tradotta (3’UTR) porta all’attivazione di oncogeni tramite l’eliminazione dei siti di legame dei microRNA, con conseguente riduzione della loro repressione in cellule tumorali. Ci siamo concentrati sul …