Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"NF-Y"”.
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STRUCTURAL ANALYSES OF TRANSCRIPTION FACTOR/DNA COMPLEXES: NFI-X AND NF-Y
… is crucial to the process by which genetic information is transferred to biological functions. TF structural analysis is the key to understanding their DNA-binding mode and for the design of specific inhibitors. In this context, the present PhD project focuses on two TFs: (1) NFI-X, a TF with …
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Qualitative and Quantitative Regulation of the Leptin Gene in vivo
… a CCAAT-binding protein Nuclear Factor Y (NF-Y). The function of NF-Y in adipocyte was studied in vitro with 3T3-L1 cells and in vivo with adipocyte-specific knockout of NF-Y. The results showed that NF-Y binding site is essential for transcriptional regulation of leptin and NF-Y is also an …
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FUNCTIONAL STUDY OF THE NONCODING REGULOME OF THE NUCLEAR FACTOR Y IN HUMAN CANCER
… caratteristiche aggressive dei tumori. Infatti, l’accorciamento della regione 3’ non tradotta (3’UTR) porta all’attivazione di oncogeni tramite l’eliminazione dei siti di legame dei microRNA, con conseguente riduzione della loro repressione in cellule tumorali. Ci siamo concentrati sul …
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Identifying a transcriptional signature for cell sensitivity to the cancer chemotherapy agent, BCNU
… a large transcription data set amenable to bioinformatics analysis. A transcriptional signature of 706 genes, differentially expressed between BCNU sensitive and resistant cell lines, was identified. Network and gene ontology enrichment identified these differentially expressed genes as being …
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THE ALTERNATIVE SPLICING OF NF-YA REGULATES MOUSE EMBRYONIC STEM CELLS DIFFERENTIATION
… entire organism. An example of these factors is NF-Y, a heterotrimeric pioneer TF promoting chromatin accessibility to other TFs to regulate gene expression. The regulatory subunit of NF-Y, NF-YA, recognizes and binds the CCAAT box motif, one of the most enriched DNA elements in enhancers and …
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Regulation of the Epstein-Barr virus C promoter by the OriP-EBNA1 complex
… human, lymphotropic herpes virus that infects more than 90% of the population worldwide. Primary infection usually occurs during the early years of life and does not result in any recognized disease. EBV is the causative agent of infectious mononucleosis and is associated with various …
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THE MESENCHYMAL IDENTITY OF NF-YA LONG ISOFORM: FROM VERTEBRATE EVOLUTION TO CANCER
NF-Y è un fattore di trascrizione pioniere altamente conservato, composto dalle subunità NF-YB/NF-YC, contenenti lo “histone fold domain” (HFD), e dal regolatore NF-YA. NF-YA riconosce il CCAAT box sul DNA, un motivo diffuso nei promotori di importanti geni coinvolti nella proliferazione …
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Computational analysis of genomic data provides insight into cell sensitivity to BCNU-Induced DNA damage
… we determined that the transcription factor NF-Y plays a key role in the differential response among cell lines, which is consistent with a model wherein transactivation of genes related to DNA repair, cell cycle arrest, and apoptosis together dictate cell fate.
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Computational analysis of genomic data provides insight into cell sensitivity to BCNU-Induced DNA damage
… we determined that the transcription factor NF-Y plays a key role in the differential response among cell lines, which is consistent with a model wherein transactivation of genes related to DNA repair, cell cycle arrest, and apoptosis together dictate cell fate.
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Die Regulation der humanen H3-Histongene
… EMSA-Analysen band der Transkriptionsfaktor CBF/NF‑Y mit unterschiedlicher Intensität an die CCAAT-Boxen des H3/k- und des H3/m-Promotors. Somit ist CBF/NF-Y vermutlich der primäre DNA-bindende Faktor in der Histon H3-Promotoraktivierung. Die Länge der Abstände zwischen proximaler und distaler …
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Regulation der Genexpression und Promotoraktivität von RGS4 durch Leptin
… transduction using the transcription factor NFkB (nuclear transcription factor kB). This work first describes the regulatory action on leptin target genes. By Western blot analysis using phosphospecific antibodies in rat RINm5F insulinoma cells, it was shown that leptin is able to activate …
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SUMOylierung von NFYA
… Funktion, Aktivität oder Lokalisation zu beeinflussen. Die kovalente Anheftung von SUMO erfordert das Zusammenspiel einer Enzymkaskade von einem E1, einem E2 Enzym und in den meisten Fällen einer E3 Ligase. Interessanterweise ist eine der wenigen bekannten SUMO E3 Ligasen, RanBP2/Nup358, ein …
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Regulation of the Insulin-like Growth Factor 1-Secretory Clusterin Expression Axis in Genomic Instability and Cell Stress
… in cancer did not repress IGF-1 and sCLU. An NF-Y binding site in the IGF-1 promoter was essential for p53 suppression, and both p53 and NF-YA bound to the IGF-1 promoter. Nutlin-3, an Mdm2-p53 inhibitor, stabilized p53 expression, leading to dramatically decreased sCLU expression. Nutlin-3 …
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NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS
NF-Y is a pioneer transcription factor that regulates the expression of genes involved in cell cycle progression and metabolism. It is composed of: NF-YA, NF-YB and NF- YC subunits. NF-YA recognizes and binds to the CCAAT box, a DNA element found enriched in the promoters of cancer-specific genes …
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INTERACTOMICS FOR RICE FLOWERING: A PROXIMITY LABELLING APPROACH
… della fioritura, come Ghd7 e le proteine di tipo NF-Y, per attivare o reprimere la trascrizione dei geni florigenici Hd3a e RFT1. Una proteina florigenica di recente caratterizzazione, chiamata FTL1, contribuisce alla differenziazione del meristema durante lo sviluppo dell'infiorescenza e della …
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Characterization of germ cell development in free-living and parasitic flatworms
… of mechanisms underlying totipotency, infertility, tumorigenesis, evolutionary development, and even pathogenesis. Here we study germ cells in the context of both free-living and parasitic flatworms. We use the freshwater planarian Schmidtea mediterranea to understand the functions of …
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Transcriptional regulation of the human alpha 2(I) procollagen gene
… formation was competed out by the mouse CBF and NF-Y consensus oligonucleotides, while the mouse anti-CBF-B antibody resulted in a supershifted complex I. These results indicate that complex I is a member of the heterologous CCAAT-binding proteins and possibly related to or similar to the mouse …
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Contribución a la detección no paramétrica de la señal radar con clutter no gaussiano
… sistemas radar; por ejemplo, antenas de haz conformado electrónicamente, subsistemas de compresión de pulsos, procesadores digitales de señales de radar, etc. Por otro lado, debido a los avances en procesado digital de señales y en modelado de clutter de los últimos años, las simulaciones …