Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"NF-KB pathway"”.
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ATM REGULATES THE NF-kB PATHWAY VIA RELA SER 276 PHOSPHORYLATION
… regulator of the double strand DNA break-repair pathway after genotoxic stress. Here we found ATM serves as an essential regulator of TNF-and RSV- induced NF-kB pathway. We observed that TNF exposure of cells rapidly induced DNA double strand breaks and activates ATM. TNF-induced ROS promote …
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RESPIRABLE SIRNA TARGETING AT THE NF-KB PATHWAY PROTECTS AGAINST INFLAMMATORY LUNG DISEASES
… obstructive pulmonary disease (COPD) are common inflammatory pulmonary diseases. Cumulative evidences have shown the role of NF-kB signaling pathway in the pathogenesis of asthma and COPD. Ribosomal protein S3 (RPS3) is a subunit of NF-kB complex while receptor-interacting protein 2 (Rip2) is a …
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Comprehensive single and paired drug target identification in healthy and disease models of NF-kB pathway
Nuclear NF-[kappa]B ("NF-[kappa]Bn") is a transcription factor responsible for regulating many genes that play important roles in inter- and intra-cellular signaling, cellular stress responses, cell growth, survival and apoptosis. Defective levels of NF-[kappa]Bn has been associated with cancer, …
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NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity
… This eventually culminates in end-organ infiltration and increased patient morbidity and mortality. In mice where the gene Map3k14 encoding NF -kB inducing kinase (NIK) is knocked out, a HES-like syndrome develops that is dependent on Th2 cells and cytokines. NIK is the upstream regulator …
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Is there a role for NF-κB in the suprachiasmatic circadian clock?
… brain areas and peripheral organs and tissues. NF-κB is composed of dimers of members of the Rel family, including p65 (RelA), p50, p52, c-Rel and Rel B. NF-κB transcription factors are required for regulating cell survival and differentiation and also are important for inflammatory and immune …
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Novel use of a cell-penetrating peptide-adaptor system to characterize Akirin constructs and investigate activity of bacterial effector proteins
… the late 1980s, HIV protein TAT was found to confer the passage of HIV through the plasma membrane of mammalian cells. The McMurry lab developed a CPP-adaptor system which consists of the fusion of TAT to calmodulin to which mediates the delivery of exogenous proteins into cells and prevents …
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Investigation onto the Mechanism Behind the Hepatoprotective Effect of Cucurbitacin Compounds
… of death worldwide. HCC is one major example of inflammatory-associated cancer. Aggressive resection or liver transplantation can successfully treat small or slow-growing tumors if they are diagnosed early. Chemotherapy and radiation treatments are not usually effective. They are mainly used to …
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Analisi genetico-molecolare dei linfomi a cellule T periferiche
… prognostication. Interestingly, proliferation pathways are commonly altered in PTCLs, being highly proliferative cases characterized by poorer prognosis. In this study, we aimed to investigate the possible role in PTCL/NOS pathogenesis of selected molecules, known to be relevant for …
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Glucocorticoid receptor signalling and the effect of interleukin 1 beta on glucocorticoid mediated gene expression in intestinal epithelial cell lines Caco-2 and IEC-6
… epithelial cells are involved in the process of inflammatory bowel disease (IBD) producing proinflammatory cytokines and chemokines. Glucocorticoids, being the most effective drugs for IBD patients, seem to have influence not only on the infiltrated inflammatory cells but also on epithelial cells. …
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OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling
… After years of effort, the signaling pathways involved in TNBC chemoresistance are gradually revealed, including the nuclear factor-kappa B (NF-kB) pathway. Transcription factor NF-kB is widely involved in cancer development and progression, and its overactivation renders …
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Overactive NF-KB signaling as a druggable target and evaluation of parthenolide an NF-KB inhibitor in canine cancer
… stand to benefit both canine and human patients. NF-kB proteins are a family of structurally related, eukaryotic transcription factors that have 400+ genetic targets, and are involved in many vital cellular processes, including innate immunity, inflammatory responses, development, cellular growth, …
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The Role of The Androgen Receptor Cofactor P44/Wdr77 In Astrocyte Activation
… activation remain to be elucidated, a number pathways have been implicated in astrocyte activation including p21<sup>Cip1</sup> and the NF-kB pathway. Astrocytic activation induced by p44/WDR77 gene deletion was associated with a significant increase of p21<sup>Cip1</sup> expression and NF-kB …
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Noncanonical NF-KB in Gastrointestinal Disease
Noncanonical NF-KB is an alternative NF-KB pathway that is critically involved in the development and maturation of the adaptive immune system. As such, it has typically been studied in B and T cell biology without application to complex organ systems such as the gut. The following work explores …
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Repression of Protein Kinase C Delta in Human Squamous Cell Carcinomas by Ras, Fyn and NF-Kappa B Signaling
… by activation of nuclear factor kappa B (NF-kB) and recruitment of repressive NF-kB subunits (p50 and c-Rel).</p><p>We also found that Fyn tyrosine kinase activation was necessary and sufficient for NF-kB activation and PKC-delta repression. In addition, Fyn was over-expressed in human …
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Investigating the role of intra- and extra-cellular modulators of the transcription factor NF-kappaB
The nuclear factor-kappa B (NF-kappaB) family of transcription factors play a pivotal role in the inflammatory and immune responses, as well as cell growth and survival. Since its discovery 25 years ago, NF-kappaB has emerged as one of the most intensely studied eukaryotic transcription factors, …
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HIF and NF-ĸB Crosstalk: The Role of HIF-1β as an Inducer of the Inflammatory Response
Inflammation and hypoxia, or decreased oxygen availability, are two relevant conditions involved in a large variety of physiological and pathological processes, such as immune diseases and cancer. At molecular level, these stress responses are strictly orchestrated by evolutionary conserved …
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Studio del pathway della Displasia Ectodermica Anidrotica (EDA)
… Ectodermal Dysplasia, encodes Ectodysplasin, a TNF family member that activates NF-kB mediated transcription. This disease can occur with mutations in other EDA-NF-kB pathway members, as EDA receptor, EDAR and its adapter, EDARADD. Moreover, mutations in TRAF6, NEMO, IKB and NF-kBs genes are …
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Lunasin and total proteins from Glycine soja and Glycine max inhibit inflammation pathways, NF-κB and hippo, in vitro through decreased expression of pro-inflammatory kinases and cytokines
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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TLR4 is a novel determinant of the response to paclitaxel in breast cancer
… of PXL to activate Toll-like Receptor-4 (TLR4) pathway. TLR4 is activated by lipopolysaccharide (LPS) and other ligands including the widely used drug PXL. TLR4 is often over-expressed in malignant epithelial cells in which its signaling hyper-activates NF-kB, MAPK and PI3K pathways providing a …
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Vitamin D Modulates Rett Syndrome Phenotypes and Underlying Cellular Pathways in an Mecp2-mutant Mouse Model
… caused by the loss of Mecp2 is aberrant NF-kB signaling. Importantly, genetically attenuating NF-kB rescues some characteristic neuronal phenotypes of RTT. Given that vitamin D (VitD) inhibits NF-kB activity and VitD deficiency is prevalent in RTT patients, the focus of this dissertation …