Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"NF-κB activation"”.
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New quinazoline analogues as NF-κB activation inhibitors
<p>NF-κB is a transcription factor protein complex that plays an important role in some cancers and inflammatory responses. It can enhance the proliferation rate, reduce apoptosis, as well as create more blood flow to ensure the survival of cancer. Thus blocking the NF-κB pathway has potential …
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Investigating the function of TRAF1 in NF-κB activation
… proteins play an important role in mediating the activation of NF-κB. Dysregulation of NF-κB may be one of the potential causes of chronic inflammatory diseases. One member of the TRAF family, TRAF1, has been shown to increase the risk of rheumatoid arthritis (RA). However, TRAF1 plays opposing …
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The Roles of Malt1 In Nf-Κb Activation and Solid Tumor Progression
<p>The transcription factor NF-κB plays a central role in many aspects of biological processes and diseases, such as inflammation and cancer. Although it has been suggested thatNF-κB is critical in tumorigenesis and tumor progression, the molecular mechanism by which NF-κB is activated in solid …
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Characterization of The Role of Carma3 In Endoplasmic Reticulum Stress-Induced Nf-Κb Activation
<p>Endoplasmic reticulum (ER) stress-induced inflammation plays an important role in the progression of many diseases, such as type II diabetes, insulin resistance, cancers, and so on. NF-κB is believed to be a central regulator of ER stress-induced inflammation. However, studies on how ER stress …
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Examination of the role of early viral protein expression in MVA-induced NF-κB activation
NF-κB, a potent pro-inflammatory cellular transcription factor, is an inhibition target for many viruses, including the prototypic poxvirus member, vaccinia virus (VACV). However, infection of HEK293T cells with the attenuated Modified Vaccinia Virus Ankara (MVA) no longer inhibits NF-κB …
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Cytokine modulations by type I interferon suppression-negative and NF-κB activation-negative Porcine Reproductive and Respiratory Syndrome Virus
… namely, type I interferons (IFNs-α/β) during infection and predisposes infected hosts to secondary bacterial infections. PRRSV also activates NF-κB signaling such that the secondary infection may trigger enhanced expression of proinflammatory cytokines. This series of cellular processes may …
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Identifying sm22 as a key player in arterial diseases
… diseases including atherosclerosis where inflammation and osteochondrogenesis are present. However, the role of this downregulation in arterial pathogenesis is unknown. Hypothesis : Downregulation of SM22 may actively contribute to arterial pathogenesis. Methods : Five Sm22 knockout …
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Role of NF-κB p65 subunit phosphorylation by ATM in DNA damage-regulated gene expression
… The DDR coordinates DSB repair, checkpoint activation, apoptosis and transcription factors regulation, including NF-κB. NF-κB family is composed of 5 proteins (RelA/p65, RelB, c-Rel, p105/p50 and p100/p52) which assemble in dimers to form active NF-κB transcription factor. In resting cells, …
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MITOCHONDRIA FACILITATE VASCULAR INFLAMMATION: THE ROLE OF CANONICAL INFLAMMATORY SIGNALING IN THE REGULATION OF MITOCHONDRIAL MORPHOLOGY
Vascular inflammation is an underlying cause to numerous diseases and is characterized by classical NF-κB activation and downstream physiological responses including inflammatory gene induction and immune cell recruitment. Although inflammatory based diseases are associated with mitochondrial …
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Characterization of the vaccinia virus ankyrin repeat protein K1 on NF-κB inhibition and its contributions to viral pathogenesis
… effects in tissue culture models of infection. We have previously published that the K1 protein inhibits double-stranded RNA-dependent protein kinase (PKR) activation. A consequence of this function is that K1 inhibits PKR-induced NF-κB activation during VACV infection. However, …
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Dissecting the Role of Novel O-GlcNAcylation of NF-κB in Pancreatic Cancer
… options for PDAC patients. The nuclear factor κB (NF-κB) is a crucial transcription factor that is constitutively activated in PDAC. It mediates the transcription of oncogenic and inflammatory genes that facilitate multiple PDAC phenotypes. Thus, a better understanding of the mechanistic …
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Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
… IpaH1.4 and IpaH2.5 for their ability to prevent NF-κB activation by targeting LUBAC. I found that IpaH1.4 specifically binds the LUBAC component HOIP and mediates its proteasomal degradation, thus abolishing linear ubiquitylation of bacteria and consecutive NF-κB activation via NEMO and autophagy …
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Real-Time Bioluminescence Imaging Of Salmonella-Neoplastic Cell Interactions
… and while the typical route of Salmonella infection and pathogenesis has been thoroughly investigated, the behavior of Salmonella in the tumor microenvironment has not. Therefore, to investigate Salmonella and host behavior during bacterial-neoplastic cell interactions, I utilized two …
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Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
… mechanism by which redox stress may activate inflammatory responses to potentially initiate, propagate and maintain many diseases states has not been characterized. Accumulating evidence suggests that pattern recognition receptors of the innate immune system such as the toll-like receptors …
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New insights into a complex host-pathogen interaction: mechanisms of Helicobacter pylori activation of NF-κB
Helicobacter pylori infection is the main cause of chronic gastritis, gastric ulcers and gastric cancer. The gram-negative spirochete, which infects more than half of the world’s population, is recognized by the International Agency for Research on Cancer as a group 1 carcinogen. The mechanism by …
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Characterization of the glycosylation and signal peptide sequences within the vaccinia virus m2 protein and influence on ERK1/2 and NF-kB activation
Activation of the NF-κB transcription factor during cellular infection establishes an anti-viral state via upregulation of proinflammatory proteins. Wild-type vaccinia virus (VV) strains subvert the immune response by expressing proteins that interfere with nuclear translocation of NF-κB. In …
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Studies of the role of nf-κb in controlling osteoclast differentiation and bone loss
… a number of mechanisms by which cytokine-induced NF-κB activation controls bone resorption and formation: 1) Tumour necrosis factor-α (TNF) expands pool of OC precursors (OCPs) by promoting their proliferation through stimulation of the expression of macrophage colony stimulating factor (M-CSF) …
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Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
… (MCV) is a dermotropic poxvirus that strictly infects humans. MCV infections produce umbilicated lesions that can persist for six to nine months in children and young adults. Currently there is no cure for MCV infections. Recent evidence suggests that the pro-inflammatory Tumor Necrosis Factor-α …
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
… its phosphorylation at S62 and T58 residues via activation of Erk1/2 and inhibition of PI3K/Akt along with subsequent activation of GSK-3β in response to low dose ATRA treatment. HL-60 cells treated with GSK-3β or proteosome inhibitors revealed marked accumulation of c-Myc both in the presence …
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Molecular Pathogenesis of MALT lymphoma
… which commonly activate the NF-κB pathway. Gastric MALT lymphomas harbouring such translocation do not respond to Helicobacter pylori eradication, while those without translocation can be cured by antibiotics. To understand the molecular mechanism of MALT lymphoma with and …
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