Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"NF-κB Pathway"”.
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Role of the IKKβ/NF-κB pathway in alcoholism
Pro-inflammatory neuroimmune signaling pathways are implicated in the acute and chronic effects of alcohol exposure. Genetic association studies in humans, gene expression microarray studies in postmortem brains of alcoholics, transcriptome meta-analysis in rodents, and drinking models in mice …
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Abrogation of serine metabolism exacerbates intestinal epithelial inflammation via C/EBPβ-NF-κB pathway
Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation and metabolic dysregulation in the intestinal epithelium. Serine, a non-essential amino acid synthesized via the rate-limiting enzyme phosphoglycerate dehydrogenase (PHGDH), maintains celular redox balance. Serine metabolism …
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New quinazoline analogues as NF-κB activation inhibitors
<p>NF-κB is a transcription factor protein complex that plays an important role in some cancers and inflammatory responses. It can enhance the proliferation rate, reduce apoptosis, as well as create more blood flow to ensure the survival of cancer. Thus blocking the NF-κB pathway has potential …
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Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
… within the gastrointestinal tract is via NF-κB signaling. This cellular signaling pathway is activated by one of two pathways: the well- defined canonical NF-κB pathway and the understudied noncanonical NF-κB pathway. The noncanonical NF-κB pathway is unique as it requires NIK, the …
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The role of the DEAD box Helicase DDX3X in Anti-‐Viral Signalling Pathways Mediated by the Kinase IKKα.
… to be involved in innate immune signalling in pathways mediated by IKKε and TBK1. In this work we show that DDX3X is also involved in pathways independent of these kinases, and functions by interacting with two related kinases IKKα and NIK. DDX3X enhances the activation of IKKα and …
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Is there a role for NF-κB in the suprachiasmatic circadian clock?
… brain areas and peripheral organs and tissues. NF-κB is composed of dimers of members of the Rel family, including p65 (RelA), p50, p52, c-Rel and Rel B. NF-κB transcription factors are required for regulating cell survival and differentiation and also are important for inflammatory and immune …
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In vitro and in vivo investigation of the anticancer activity and molecular mechanisms of disulfiram in non-small cell lung cancer
… hypoxia induced activation of the nuclear factor-κB (NF-κB) pathway; a pivotal regulator of CSCs. Therefore, development of an NF-κB and CSC targeting drug will improve NSCLC therapeutic outcomes. New drug development is an expensive and time-consuming procedure. DS demonstrates excellent in vitro …
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Exploring the Role of IL-1β/IL-1R in the Pathogenesis of K-ras Mutant Lung Cancer
… partly occurs through activation of the NF-κB pathway initiating an inflammatory response and creating a pro-tumor microenvironment. Notably, the pro-inflammatory cytokine IL-1β a potent activator and product of the NF-κB pathway is elevated in the lungs and sera of KM-LUAD patients. We …
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The non-canonical NF-kappaB pathway as a novel player in beta cell dysfunction in diabetes
… type-1 and type-2 diabetes. The non-canonical NF-κB pathway has recently garnered attention at being involved in the development of peripheral insulin resistance (liver, muscle) in diabetes. Whether pancreatic β cell non-canonical NF-κB signalling contributes to glucose homeostasis and diabetes …
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Exploring the role of IRF4 in the sensitivity of mantle cell lymphoma cells to Bruton's Tyrosine Kinase inhibitors
… and key signalling partners of the alternative NF-κB pathway in response to BTKi drugs in both BTKi-resistant ex vivo primary cells or cell lines with innate or acquired BTKi-resistance. The work shows also that CD40L presented by stromal cells can induce BTKi resistance in sensitive MCL cells …
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Inhibition of Heat Shock Protein 90 Reduces Inflammatory Signal Transduction in Murine J774 Macrophage Cells and Lessens Disease in Autoimmune MRL/lpr Mice: What in vitro, in vivo, and in silico Models Reveal
… has hundreds of clients, many of which are inflammatory signaling kinases. The mechanism by which HSP90 enables inflammatory pathways is an active area of investigation. The HSP90 inhibitors such as geldanamycin (GA) and its derivative 17-dimethylaminoethylamino-17-demethoxygeldanamycin …
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A BIOMARKER ENRICHMENT PHASE II TRIAL OF 177LU-DOTATATE IN METASTATIC NASOPHARYNGEAL CANCER WITH A SAFETY RUN-IN
… (EBV) latent membrane protein 1 (LMP1) via the NF-κB pathway and SSTR2 expression can be seen in vitro and in vivo in certain other EBV related cancers (NCT05581550). We also report the initial results of our phase 2 therapeutic trial (NCT05198479) to study the efficacy of targeting SSTR2 with …
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
… suppressor by its function of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory diseases. However, the understanding of how RKIP expression level is …
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
… suppressor by its function of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory diseases. However, the understanding of how RKIP expression level is …
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THE ROLE of THE CIRCADIAN CLOCK IN DISEASE and TISSUE FUNCTION
… NOB significantly alleviated the strong neuroinflammation and astrogliosis in AD model APP/PS1 mice. NOB also significantly improved glucose utilization and insulin signaling in these mice. Furthermore, I report initial evidence for a possible NOB-ROR downstream mechanism through Ephrin …
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Feedback Regulation of Human Hematopoietic Stem Cell Fate
… blood cells produce ligands that act on HSCs to influence HSC fate. However, fundamentals underlying the feedback regulation of HSC fate are poorly understood. Here, we explored the fundamentals of the feedback regulation of HSC fate at the microenvironmental, intercellular (between cells), and …
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Investigating the Role of Pellin03 in TNF Signalling
Tumor necrosis factor (TNF) is an important modulator of the innate immune system, responsible for the activation of immune cells as well as the removal of damaged cells. Aberrant TNF signalling can cause a number of pathologic conditions. TNF binding to TNF receptor 1 triggers the activation of …
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The Role of TGF-β in CTB-Insulin Regulated Human Dendritic Cell Tolerance
… that CTB-INS activates the non-canonical NF-κB pathway to induce IDO1 biosynthesis in human DCs. However, experiments presented in this dissertation demonstrate that the CTB-INS fusion protein also stimulates biosynthesis of the immunoregulatory molecules TGF-β1, activin-A and integrin …
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Cerebrovascular and Neuronal Cellular Consequences of Amyloid-β Induced Nuclear Factor-κB Activation
… observed in the vasculature and brain, such as inflammation, suggest that a common element in cerebrovascular and neuronal cells mediates disease progression. With its significant role in inflammatory responses, the nuclear factor-κB (NF-κB) pathway is hypothesized to play such a regulatory …
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