Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 320 for “"NF-κB"”.
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New quinazoline analogues as NF-κB activation inhibitors
<p>NF-κB is a transcription factor protein complex that plays an important role in some cancers and inflammatory responses. It can enhance the proliferation rate, reduce apoptosis, as well as create more blood flow to ensure the survival of cancer. Thus blocking the NF-κB pathway has potential …
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Investigating the function of TRAF1 in NF-κB activation
… an important role in mediating the activation of NF-κB. Dysregulation of NF-κB may be one of the potential causes of chronic inflammatory diseases. One member of the TRAF family, TRAF1, has been shown to increase the risk of rheumatoid arthritis (RA). However, TRAF1 plays opposing roles in the …
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Role of the IKKβ/NF-κB pathway in alcoholism
Pro-inflammatory neuroimmune signaling pathways are implicated in the acute and chronic effects of alcohol exposure. Genetic association studies in humans, gene expression microarray studies in postmortem brains of alcoholics, transcriptome meta-analysis in rodents, and drinking models in mice …
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Regulation of NF-κB by PML and PML-RARα
The transcription factor NF-κB is the master regulator of the immune response but also acts broadly to regulate gene expression that influences cell survival, proliferation and differentiation. Post-translational modification of NF-κB, phosphorylation in particular, is essential for the …
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Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
… within the gastrointestinal tract is via NF-κB signaling. This cellular signaling pathway is activated by one of two pathways: the well- defined canonical NF-κB pathway and the understudied noncanonical NF-κB pathway. The noncanonical NF-κB pathway is unique as it requires NIK, the …
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Examining Altered NF-κB Signalling Following 1,4- Benzoquinone Exposure in HD3 Cells
… alter the redox sensitive transcription factor NF-κB, which is up-regulated in leukemia. We hypothesize that this is through benzene-induced reactive oxygen species (ROS) production interfering with the signalling pathway involving NF-κB, p38-MAPK and c-Myb. The objectives were to determine if …
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The Roles of Malt1 In Nf-Κb Activation and Solid Tumor Progression
<p>The transcription factor NF-κB plays a central role in many aspects of biological processes and diseases, such as inflammation and cancer. Although it has been suggested thatNF-κB is critical in tumorigenesis and tumor progression, the molecular mechanism by which NF-κB is activated in solid …
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Is there a role for NF-κB in the suprachiasmatic circadian clock?
… brain areas and peripheral organs and tissues. NF-κB is composed of dimers of members of the Rel family, including p65 (RelA), p50, p52, c-Rel and Rel B. NF-κB transcription factors are required for regulating cell survival and differentiation and also are important for inflammatory and immune …
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Dissecting the Role of Novel O-GlcNAcylation of NF-κB in Pancreatic Cancer
… options for PDAC patients. The nuclear factor κB (NF-κB) is a crucial transcription factor that is constitutively activated in PDAC. It mediates the transcription of oncogenic and inflammatory genes that facilitate multiple PDAC phenotypes. Thus, a better understanding of the mechanistic …
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A study of the NF-κB signalling pathway in human acute myeloid leukaemia.
The transcription factor NF-κB can play both a protective and destructive role in cells. NF-κB protects by signalling for the immune system when cells fall under attack from pathogens. NF-κB signalling becomes a danger to cells when signalling becomes constitutive and can promote excessive …
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Studies of the role of nf-κb in controlling osteoclast differentiation and bone loss
… a number of mechanisms by which cytokine-induced NF-κB activation controls bone resorption and formation: 1) Tumour necrosis factor-α (TNF) expands pool of OC precursors (OCPs) by promoting their proliferation through stimulation of the expression of macrophage colony stimulating factor (M-CSF) …
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Liquid-Liquid Phase Separations in Innate Immune DNA Sensing and NF-κB Signaling Pathways
… mechanism across immune signaling pathways. NF-kappa-B essential modulator (NEMO), also known as IKBKG, is essential for the activation of IκB kinase (IKK) complex in NF-κB signaling, including Interleukin-1 (IL-1β), Tumor Necrosis Factor (TNFα) and Toll-like receptors (TLR) pathways. NEMO …
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Characterization of The Role of Carma3 In Endoplasmic Reticulum Stress-Induced Nf-Κb Activation
<p>Endoplasmic reticulum (ER) stress-induced inflammation plays an important role in the progression of many diseases, such as type II diabetes, insulin resistance, cancers, and so on. NF-κB is believed to be a central regulator of ER stress-induced inflammation. However, studies on how ER stress …
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Abrogation of serine metabolism exacerbates intestinal epithelial inflammation via C/EBPβ-NF-κB pathway
Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation and metabolic dysregulation in the intestinal epithelium. Serine, a non-essential amino acid synthesized via the rate-limiting enzyme phosphoglycerate dehydrogenase (PHGDH), maintains celular redox balance. Serine metabolism …
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Role of NF-κB p65 subunit phosphorylation by ATM in DNA damage-regulated gene expression
… and transcription factors regulation, including NF-κB. NF-κB family is composed of 5 proteins (RelA/p65, RelB, c-Rel, p105/p50 and p100/p52) which assemble in dimers to form active NF-κB transcription factor. In resting cells, NF-κB complexes are bound to inhibitor proteins such as IκBα, and …
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Examination of the role of early viral protein expression in MVA-induced NF-κB activation
NF-κB, a potent pro-inflammatory cellular transcription factor, is an inhibition target for many viruses, including the prototypic poxvirus member, vaccinia virus (VACV). However, infection of HEK293T cells with the attenuated Modified Vaccinia Virus Ankara (MVA) no longer inhibits NF-κB …
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