Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"NFκB"”.
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HIV Tat Protein Activates Endothelial Cells through NFκB and MAP Kinase Pathways.
… were analyzed for MAP Kinase activity and NFκB activation, and culture supernatants were assayed for inflammatory cytokines (IL-6 and IL-8). The production of IL-6 and IL-8 was significantly enhanced by tat but not by gp120. Both gp120 and tat, however, induced significant morphological …
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Mutations In Stat3 Associated With Human Hyper Ige Syndrome Enhance Nfκb and Mapk-Mediated Gene Expression
… osteoclast and inflammatory cytokine genes are NFκB targets, these observations indicate a possible deregulation of NFκB signaling in both mice and humans with STAT3-deficiency. Here, we sought to examine the role of STAT3 in the regulation of NFκB-mediated gene expression through analysis of …
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In vitro investigation of the effect of disulfiram on hypoxia induced NFκB, epithelial to mesenchymal transition and cancer stem cells in glioblastoma cell lines
… and displayed increased levels of HIFs and NFκB activity. Similarly, the hypoxia cultured GBM cells manifested GSC traits, chemoresistance and invasiveness. These results suggest that hypoxia is responsible for GBM stemness, chemoresistance and invasiveness. GBM cells transfected with …
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P53 mediated cell motility in H1299 lung cancer cells
… that gain-of- function mutant p53, AKT, and NFκB promote invasion and metastasis in tumor cells. Signals transduced by AKT and p53 are integrated via negative feedback between the two pathways. Tumor derived p53 was also indicated to induce NFκB gene expression. Due to the close relationship …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… transcription factor, nuclear factor kappa 8 (NFκB) and heat shock proteins (HSPs) are two redox-sensitive cellular responses of most immune and inflammatory diseases including diabetes and its late vascular complications. NFκB promotes the transcription of a wide array of proinflammatory …
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Characterisation of the role of human Evolutionary Conserved Signalling Intermediate in Toll (ECSIT) in Mitogen Activated Protein Kinase (MAPK) signalling
… homolog mECSIT has been shown to be involved in NFκB, MAPK, BMP and mitochondrial signalling. To date there is no work published on the human homolog, hECSIT. In this thesis, I present data indicating that hECSIT is involved in NFκB, BMP and MAPK signalling. There is a striking difference in the …
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Transcriptional and Post-transcriptional Control of Nhlh2 with Differing Energy Status
… Kappa-Light-Chain-Enhancer of Activated B Cells (NFκB) binding site motifs at -67 and -135. While NFκB acts as a negative regulator of Nhlh2, this research showed that Stat3 acts as a regulator for the Nhlh2 basal expression and leptin stimulation. The ChIP assay using chromatin from mouse …
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Mechanisms of DNA double strand break-mediated neurotoxicity in neurodegenerative disease
… enter a late-stage DNA damage response marked by NFκB-activated senescent and antiviral immune pathways. In humans, Alzheimer’s disease pathology is significantly associated with immune activation in excitatory neurons. Spatial transcriptomics reveal that regions of CK-p25 brain tissue dense with …
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The effects of chrysin on osteoclastogenesis in RAW264.7 murine macrophages and bone metabolism in Sprague Dawley rats
… the translocation of nuclear factor kappa B (NFκB) to the nucleus. Micro-computed tomography (microCT) was utilised to assess the tibia bones in Sprague-Dawley rats. The parameters evaluated of the whole bone, length, volume, surface area, bone volume fraction, segmented surface density, and …
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Crosstalk between Inflammation and Coagulation in Acute Pancreatitis - Experimental and Clinical Studies.
… paper the activation of nuclear factor kappa B (NFκB) is studied in the rat model of severe AP. NFκB is a pivotal transcription factor, involved in the regulation of expression of multiple inflammatory mediators. The results show a decreased activation of NFκB in remote organs in FVIIai …
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Senescence Associated Secretory Phenotype Regulation in Lung Aging and Malignancy Progression
… of the SASP via activation of the canonical Src-NFκB pathway, resulting in the subsequent onset of a full senescent state. The CD36-mediated secretome is further shown to be ligand-dependent, as fibroblast cultures lacking the CD36 ligand amyloid beta (Aβ) are unresponsive to CD36 upregulation …
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The role of type I interferon in chronic lymphocytic leukemia
… kappa light chain enhancer of activated B cells (NFκB) signaling within CLL cells in vivo and in vitro. Increased IFN-signaling was associated with loss of an initial clinical response to anakinra. The results from this trial suggested anakinra acts as an NFκB inhibitor and may be a promising …
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Investigating peripheral inflammation induced neuroinflammation in the absence of blood-brain barrier breakdown in relation to Alzheimer’s disease
… of the barrier activated primary microglia in an NFκB-dependent manner, and mass spectrometry highlighted Von Willebrand factor (VWF) as a candidate endothelial-derived mediator. Recombinant VWF reproduced microglial inflammatory activation via NFκB signalling. To further assess these mechanisms …
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Investigation of the anti-breast cancer efficacy and mechanisms of disulfiram
… of the spheres. Transfection of BC cells with NFκB p65 induces CSC characters and chemoresistance. Therefore hypoxia-induced activation of NFκB could lead to escape of CSCs from apoptosis and regenerate the tumour after conventional chemotherapy. In clinic, the relapsed cancer is commonly …
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DEVELOPMENT OF AN IN VIVO MULTITASKING BIOLUMINESCENT REPORTER GENE PLATFORM FOR THE PRECLINICAL EVALUATION OF RNA THERAPEUTICS
… in vivo. To address this gap, complementary NFκB-luc2 and STAT6-luc2 reporter mouse models were implemented to enable real-time monitoring of pro-inflammatory pathway and Th2 immune response. A novel STAT6-luc2 reporter line was generated and validated to this purpose. When combined with the …
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Investigations into the Biological Roles of the E3 ligase Ariadne 2/TRIAD1
… This may be linked to modulation of the NFκB and ERK pathways, in particular increase in nuclear p65/RelA and phospho-p65/RelA leading to an increase in NFκB and AP-1 binding to DNA and sustained and hyperactive NFκB response in Arih2-/- dendritic cells. Overall, Ariadne 2 is shown to be …
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MicroRNA-mediated Attenuation of Inflammation in NZB/W Lupus Mice
… miR-let-7a-mediated proliferation and NFκB activation in J774A.1 macrophages and MES 13 mesangial cells in vitro. Cell proliferation, retinoblastoma protein (Rb) phosphorylation, and NFκB activation were increased in cells transfected with miR-let-7a and stimulated with LPS/IFN-γ. …
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Modulation of Fatty Acid-Induced Skeletal Muscle Inflammation by the Peripheral Endocannabinoid System.
… insulin resistance and induce proinflammatory NFκB signalling in skeletal muscle. However, whilst endocannabinoids, acting via specific cell surface cannabinoid (CB1 and CB2) receptors, have been shown to suppress insulin signalling in muscle it remains unknown whether they also stimulate or …
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Protektiver Effekt von 6-Shogaol, Ellagsäure und Myrrhe auf die intestinale epitheliale Barriere
… gesteigerte Claudin-2-Expression sowie eine NFκB-vermittelte Umverteilung des abdichtenden TJ-Proteins Claudin-1 gekennzeichnet. 6-Shogaol konnte den TER-Abfall partiell hemmen sowie die PI3K/Akt-induzierte Claudin-2-Expression und die NFκB-bedingte Claudin-1-Umverteilung verhindern. Ebenso …
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Investigations into novel signalling pathways in the response to viral and bacterial infections
… TLR7 signalling was shown to activate IRF3 and NFκB in murine bone marrow derived macrophages. However, while TLR7 mediated IRF3 activation was TRAM dependent, NFκB activation was not. TRAM was also shown to mediate signalling via a physiological activator of TLR7, human rhinovirus 16 (HRV16). …
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