Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 882 for “"NF"”.
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NF
A study Of Quine's Set Theory
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Noncanonical NF-KB in Gastrointestinal Disease
Noncanonical NF-KB is an alternative NF-KB pathway that is critically involved in the development and maturation of the adaptive immune system. As such, it has typically been studied in B and T cell biology without application to complex organ systems such as the gut. The following work explores …
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Erzeugung und Analyse NF-ATp-defizienter Mäuse
Ziel dieser Arbeit war es, NF-AT1-Gen-defiziente Mauslinien zu erzeugen und die Folgen dieser genetischen Manipulation in vivo zu untersuchen. Die Untersuchung sollte die durch die Gendefizienz erwarteten Mängel während der Entwicklung (Embryogenese) und, im Besonderen, die Auswirkungen auf das …
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Overactive NF-KB signaling as a druggable target and evaluation of parthenolide an NF-KB inhibitor in canine cancer
… stand to benefit both canine and human patients. NF-kB proteins are a family of structurally related, eukaryotic transcription factors that have 400+ genetic targets, and are involved in many vital cellular processes, including innate immunity, inflammatory responses, development, cellular growth, …
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ROLE OF P50 NF-KB IN MACROPHAGE MIGRATION
… such as a massive accumulation of the p50 NF-B homodimer in the nucleus and the incapacity to express strong inflammatory programs (eg. impaired TNF production) in response to inflammatory signals such as LPS (tolerance). Our recent study has described that both TAM and LPS-tolerant …
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NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS
NF-Y is a pioneer transcription factor that regulates the expression of genes involved in cell cycle progression and metabolism. It is composed of: NF-YA, NF-YB and NF- YC subunits. NF-YA recognizes and binds to the CCAAT box, a DNA element found enriched in the promoters of cancer-specific genes …
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Ubiquitin Mediated Regulation of NF-kappa B Signaling
NF-κB signaling is involved in many vital cellular functions such as immunity, cell proliferation, inflammation, and apoptosis. The activation of NF-κB signaling requires the process of ubiquitination. K63-and K48-linked ubiquitin chains have been shown to have distinct roles and biological …
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New quinazoline analogues as NF-κB activation inhibitors
<p>NF-κB is a transcription factor protein complex that plays an important role in some cancers and inflammatory responses. It can enhance the proliferation rate, reduce apoptosis, as well as create more blood flow to ensure the survival of cancer. Thus blocking the NF-κB pathway has potential …
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Modulation de NF-kB par Lactobacillus helveticus R389
"L'huître américaine, Crassostrea virginica, est non seulement une espèce d'importance écologique de nos baies et estuaires, mais une espèce qui démontre aussi un potentiel économique important pour plusieurs régions côtières de l'Est du Canada. Au Canada atlantique, l'une des populations …
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Investigating the function of TRAF1 in NF-κB activation
… an important role in mediating the activation of NF-κB. Dysregulation of NF-κB may be one of the potential causes of chronic inflammatory diseases. One member of the TRAF family, TRAF1, has been shown to increase the risk of rheumatoid arthritis (RA). However, TRAF1 plays opposing roles in the …
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Roles of NF-kB in spinal cord injury pathophysiology
… affected after SCI is the transcription factor NF-kB. We used two-month-old male rats and subjected them to a contusion spinal cord injury to elucidate the differential changes in NF-kB subunits and NF-kB-dependent changes after SCI. We observed an increase in cell death 12 hours after SCI, with …
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Role of the IKKβ/NF-κB pathway in alcoholism
Pro-inflammatory neuroimmune signaling pathways are implicated in the acute and chronic effects of alcohol exposure. Genetic association studies in humans, gene expression microarray studies in postmortem brains of alcoholics, transcriptome meta-analysis in rodents, and drinking models in mice …
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Aktivierung des nukleären Transkriptionsfaktors kappaB (NF-kappaB) durch Verapamil
… von Bestandteilen des Transkriptionsfaktors NF-kappa B und dessen Inhibitorprotein IkappaB durchgeführt. Des weiteren wurden EMSAs zur Aktivitätsbestimmung des Transkriptionsfaktors NF-kappa B durchgeführt. Bei den kardialen Schweinefibroblasten konnte eine Aktivierung des …
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Regulation of NF-κB by PML and PML-RARα
The transcription factor NF-κB is the master regulator of the immune response but also acts broadly to regulate gene expression that influences cell survival, proliferation and differentiation. Post-translational modification of NF-κB, phosphorylation in particular, is essential for the …
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Development and characterization of dendrimeric NF/RO polyamide membranes
Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2014-01-24T14:14:50Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Martinez Saenz de Jubera_Ana.docx: 9222947 bytes, checksum: 443ea8b453c942240f8efa7f833c1a02 (MD5) Martinez Saenz de …
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Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
… within the gastrointestinal tract is via NF-κB signaling. This cellular signaling pathway is activated by one of two pathways: the well- defined canonical NF-κB pathway and the understudied noncanonical NF-κB pathway. The noncanonical NF-κB pathway is unique as it requires NIK, the …
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Cis and Trans, p53 and NF-kB rules of transactivation
p53 and NF-kB families of Transcription Factors (TFs) are among the most studied proteins in tumour biology, typically known to function as antagonists, although recent studies identified example of positive, even cooperative interactions. p53 and NF-kB act as dimer or dimer of dimers, bind cis …
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Haploid reporter screens aimed at identification of NF-kappaB regulators
Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such as cell survival, differentiation, proliferation, and inflammation. …
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ATM REGULATES THE NF-kB PATHWAY VIA RELA SER 276 PHOSPHORYLATION
… found ATM serves as an essential regulator of TNF-and RSV- induced NF-kB pathway. We observed that TNF exposure of cells rapidly induced DNA double strand breaks and activates ATM. TNF-induced ROS promote nuclear IKKr-ubiquitin association and complex formation with ATM for nuclear export. …
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Modeling Of Membrane Solute Mass Transfer In Ro/nf Membrane Systems
Five articles describing the impact of surface characteristics, and development of mass transfer models for diffusion controlled membrane applications are published in this dissertation. Article 1 (Chapter 3) describes the impact of membrane surface characteristics and NOM on membrane performance …
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