Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"NEUROD1"”.
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Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1
… factors in this process are NRSF/REST and NeuroD1. NRSF/REST, a transcriptional repressor that binds a specific NRSE site and recruits corepressors and chromatin remodeling machinery to repress its target genes, is critical for maintenance of the neural stem cell pool and for proper pacing …
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The role of cnd-1/NeuroD1 in C. elegans nervous system development
<p>NeuroD1 is a vertebrate helix-loop-helix transcription factor that is involved in nervous system development and pancreatic islet development. NeuroD1 -/- mice is uncoordinated, has seizures and a reduce brain size (Miyata et al. 1999). In C. elegans, the ortholog gene is <em>cnd-1</em>. Hallam …
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Direct Reprogramming Of Fibroblasts Into Muscle Or Neural Lineages By Using Single Transcription Factor With Or Without Myod Transactivation Domain
… involved in myogenesis (Pax3) or neurogenesis (NeuroD1) alone can directly reprogram the mouse embryonic fibroblasts (MEFs) into myogenic or neurogenic lineages, respectively. In addition, we created fusion transcription factors (Pax3 or NeuroD1) with the potent MyoD transactivation domain (MDA) …
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IDENTIFICATION OF KEY MOLECULES IN PLACODE-DERIVED NEURONS THAT COORDINATE CHICK TRIGEMINAL GANGLIOGENESIS
… (Neurog2), Neuronal Differentiation 1 (NeuroD1), and Elongator acetyltransferase complex subunit 1 (Elp1) for further study. While Neurog2, NeuroD1, and Elp1 have established roles in neurogenesis in other systems, their functions in placode cells during trigeminal gangliogenesis had yet …
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Identification d'effecteurs de la signalisation Delta/Notch dans la différenciation des cellules endocrines du système digestif
… de la lignée endocrine. Le facteur neurod1, appartenant à la famille des ARP, agit plus tardivement dans le développement de cette lignée afin de permettre le maintien du programme de différenciation endocrine. Nous démontrons que ces deux facteurs agissent séquentiellement dans les …
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Defining oncogenic determinants in prostate cancer initiation and progression
… critical roles of the pioneer factors ASCL1 and NEUROD1 in neuroendocrine transdifferentitation and uncovered their abilities to silence AR expression and signaling by remodeling chromatin at the somatically acquired AR enhancer and global AR binding sites with enhancer activity. We have …
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
… lineage transcription factors including ASCL1, NEUROD1, POU2F3, or YAP1. The expression of various MYC family members leads to further inter-tumor heterogeneity. Despite this heterogeneity in SCLC, the current treatment for SCLC is lineage-transcription-factor-subtype agnostic. Although most …
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Characterisation of L-cell secretory mechanisms and colonic enteroendocrine cell subpopulations
… from mice with a pan-EEC fluorescent marker (NeuroD1- Cre:Rosa26-EYFP). This illustrated that INSL5-producing L-cells form one of two transcriptomically distinct subpopulations of L-cells in the murine colon, with the other distinguished by expression of neurotensin (Nts). Another major EEC …
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Neurodegeneration und Neuroprotektion bei der Parkinson-Krankheit: Untersuchungen von β-Carbolinen und dem Dopaminagonisten Lisurid in der dopaminergen mesencephalen Primärzellkultur des Mausstammes C57Bl/6
… die Expression der Transkriptionsfaktoren NeuroD1 und Tcf3 hochreguliert, die in Differenzierungsprozesse involviert sind. NeuroD1 gilt dabei als proneurales Gen und ist somit möglicherweise an Vorgängen der Neuroprotektion beteiligt. Keines der validierten differentiell exprimierten Gene …
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Exploring the Grey Zone between Type 1 and Type 2 Diabetes
… (MODY 4), HNF-1ß, formerly TCF2 (MODY 5) and NeuroD1 (MODY6). The goal of this thesis was to genetically dissect autoimmune (T1D and LADA) and non-autoimmune (T2D and MODY) diabetes in young (15-34 years old)and middle-aged (40-59 years old) Swedish diabetic patients for proper diagnosis and …
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Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of …