Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 71 for “"NEMO"”.
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Binding NEMO: Adventures in Molecular Dynamics
Molecular dynamics is an indispensable tool for dissecting atomic-level interactions of critical physiological macromolecules.
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Untersuchungen zur Identifikation von Interaktionspartnern der Nemo-like-Kinase, Nlk
Die Nemo-like-Kinase, Nlk, ist eine Serin-/Threonin-Kinase, die den MAP Kinase- mit dem Wnt Signaltransduktionsweg verbindet. Die einzigen bisher beschriebenen Interaktionspartner von Nlk sind β-Catenin, LEF-1, XTCF-3 und TCF-4. Im Rahmen der vorliegenden Arbeit wurde versucht, ein sogenanntes …
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ASSESSING MUTATIONS IN A ZINC FINGER DOMAIN OF NF-κB ESSENTIAL MODULATOR (NEMO) USING MOLECULAR DYNAMICS SIMULATIONS
Molecular dynamics (MD) simulations permit the probing of biomolecular systems in
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Finding NEMO by the molluscum contagiosum virus MC159 protein and its effect on viral pathogenesis in vivo
… anti-viral response, via interactions with the NEMO subunit of the IKK complex. The exact molecular mechanism that inhibited IKK and NF-kB activation remained unknown and the work presented here identifies this mechanism. Briefly, I found that MC159 antagonizes cIAP1-NEMO interactions to inhibit …
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A natural language processing approach to improve demand forecasting in long supply chains
… techniques in a deep learning model, known as NEMO, to forecast the demand of a commodity -- without requiring downstream companies to share information. In addition, this thesis compares the effectiveness of such an approach with other non-deep learning approaches, specifically an ARIMA model …
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Liquid-Liquid Phase Separations in Innate Immune DNA Sensing and NF-κB Signaling Pathways
… pathways. NF-kappa-B essential modulator (NEMO), also known as IKBKG, is essential for the activation of IκB kinase (IKK) complex in NF-κB signaling, including Interleukin-1 (IL-1β), Tumor Necrosis Factor (TNFα) and Toll-like receptors (TLR) pathways. NEMO activates IKK complex by binding …
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Nemo no more? Spatial demographic and population genetic analyses of the two-band anemonefish, Amphiprion bicinctus, in the Gulf of Eilat, Red Sea
Anemonefishes' obligatory mutualism with sea anemones dictates their occurrence on coral reefs. I examined spatial distribution, settlement, habitat usage, and survival patterns of the two-band anemonefish, Amphiprion bicinctus. In a 300 X 30 m study site off the coast of Israel in the Gulf of …
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Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition
… (IKKα and IKKβ) and one regulatory subunit (IKKγ/NEMO) acts as the master regulator of NF-κB transcription factor activity. Seminal genetic studies in knockout (KO) mouse embryonic fibroblasts (MEFs) have defined two pathways of NF-κB activation; a canonical pathway, activated in response to …
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Nemo dat quod non habet (no one can give what they do not possess): the faith development needs of the authentic and authoritative Catholic teacher.
This study was set within the context of Catholic Education in Scotland; a context that holds a unique historic position, operating within the state education system. It investigated and explored the faith development experiences of Catholic teachers as they progressed from their initial teacher …
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Studio del pathway della Displasia Ectodermica Anidrotica (EDA)
… adapter, EDARADD. Moreover, mutations in TRAF6, NEMO, IKB and NF-kBs genes are responsible for Immunodeficiency associated EDA (EDA-ID). Several molecules, as SHH, WNT/DKK, BMP and LTβ, have already been reported to be EDA pathway regulators or effectors although the knowledge of the full …
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Measurement of the double beta decay half-life of ^{100}Mo to the 0^{+}_{1} excited state, and ^{48}Ca to the ground state in the NEMO 3 experiment
NEMO 3 is a double beta decay experiment situated in the Fréjus tunnel which runs between France and Italy. If neutrinoless double beta decay is observed it will prove the neutrino is a Majorana particle and may potentially become the most sensitive method of measuring the absolute neutrino mass. …
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De schutter beschermd; een onderzoek naar de beschermende werking van het nemo tenetur beginsel tijdens strafzaken tegen militairen na een huishoudelijk onderzoek en tegen politieambtenaren na de verplichte melding na geweldgebruik
… is mee te werken aan zijn eigen veroordeling (nemo tenetur) ?
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Disrupting the inhibitory Kappa B kinase (IKK) - Aurora A axis in cancer
… protein IKKγ/NF-κB Essential Modulator (NEMO). The complex can be assembled in multiple conformations as either hetero- or homo-dimers of IKKα/β with or without the scaffolding protein IKKγ. This regulates NF-κB signalling and related cellular inflammatory responses that are often …
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The DNA methylation landscape of metastatic prostate cancer: from characterization to liquid biopsy applications
… contribution is the design and development of NEMO, a tailored liquid biopsy sequencing panel approach to allow non-invasive neuroendocrine castration-resistant prostate cancer detection in patients with metastatic disease. Based on previous results and the comprehensive analysis of multiple …
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Fiendish Dreams - Reverse Engineering Modern Architecture
… from 1904 to 1911, psychic twin to Little Nemo in Slumberland that appeared concurrently in the Sunday Funnies of the New York Herald from 1905-1911. 'Slumberland' was a Neo-classical fantasy that closely resembled the idealized White City of the Chicago World's Fair (1893), that inspired …
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Applications of High Speed Configurable Logic Devices in Modern Particle Physics Experiments
… were conducted during my PhD activity. For the NEMO experiment a collaboration between the INFN/University groups of Catania and Bologna led to the development and production of a mixed signal acquisition board for the Nemo Km3 telescope. The research concerned the feasibility study for a …
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Genetic Mechanisms Responsible for Dietary Restriction Dependent Lifespan Extension in Drosophila Melanogaster: A Role for Muscle Tissue
… of 4E-BP were identified from screening: Fumble, Nemo, and Nedd2-like Caspase. Both Fumble and Nemo extend lifespan upon DR when inhibited in the muscle tissue. While these candidate genes hold promise for future studies in healthy aging, sources of variation in results must be controlled. In …
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CRYSTAL STRUCTURE ENGINEERING FOR IMPROVED PERFORMANCE OF EMERGING NANOSCALE DEVICES
… substrates. (2) Augment/extend the open source NEMO 3-D bandstructure simulator by incorporating a recently proposed first principles based model to gauge the importance of nonlinear piezoelectricity on the single-particle electronic states and interband optical transitions in emerging …
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